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Hotels in Mississippi River

Find and book unique hotels on Airbnb

Top-rated hotels in Mississippi River

Guests agree: these hotels are highly rated for location, cleanliness and more.

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Superhost
A modern suite features large windows that allow natural light to fill the space, showcasing a blend of rustic beams and sleek finishes. An open kitchen with a marble countertop is complemented by stylish seating, while decorative accents add a touch of personality.
Hotel room in Madison
4.81 out of 5 average rating, 201 reviews

Two Bedroom with Lake View

DISCOVER A UNIQUE WAY TO EXPERIENCE LIVING IN THE HEART OF DOWNTOWN MADISON. Once a historic saddlery, our modern suites offer the perfect blend of comfort & convenience will fully furnished interiors, including a full kitchen that allows you to prepare meals just like at home. We are a pet-friendly establishment. With in-unit washer & dryer, cable TV, WiFi, secure digital entry & housekeeping available upon request. We've got all your needs covered for a seamless and enjoyable experience!

Guest favourite
A winter scene showcases a snow-covered landscape along Lake Superior. The sky is filled with soft clouds and sunlight reflects off the water, while snow-covered trees and a patio area with seating can be seen in the foreground.
Hotel room in Duluth
4.82 out of 5 average rating, 66 reviews

Great Lakes Suite @ InnOnGitcheGumee

The Great Lakes Suite – A Maritime Escape on Lake Superior Elevate your North Shore getaway in our lovingly appointed Great Lakes Suite, a cozy retreat perched on the second floor with sweeping views of Lake Superior’s dramatic expanse. Picture yourself nestled in a queen-sized captain’s bed, wrapped in a hand-stitched quilt, as the panorama unfolds—cargo ships gliding on the horizon, storm clouds rolling in over the water, and sunrises that illuminate the surface in golden hues.

Superhost
A comfortable seating area is showcased with a green couch adorned with pillows and a soft blanket. A wooden coffee table sits on an area rug, while a lamp illuminates the side table. Exposed brick walls add character, and natural light enters through a window.
Hotel room in Picayune
4.89 out of 5 average rating, 106 reviews

The Depot Suites Suite 201

Downtown Picayune. Come and enjoy a charming stay at one of our three newly renovated suites. The festive atmosphere of our downtown life and modern boutiques will please any desire to sit back and relax. Enjoy one of our downtown restaurants and full bars with great music and often live bands. Minutes away from New Orleans or the Mississippi Gulf Coast. Sit outside on the balcony and take in a beautiful sunset over our historical downtown with an at home southern comfort.

Superhost
A spacious guest room features a large bed with white linens and a neutral headboard against a wooden accent wall. A cozy armchair sits near a large window, providing natural light. A flat-screen television and desk area are included, along with bedside lamps for illumination.
Hotel room in Plano
4.87 out of 5 average rating, 459 reviews

In the Heart Of It All | Sightseeing. Free Parking

Everything we do at Four Points by Sheraton Plano Hotel in Texas shows our respect for great design and a sense of the local. Delicious breakfast to start the day right, dining options in the evening, and free WiFi throughout the hotel enables our guests to stay in touch socially and at work. Plus, at Four Points, workouts are not confined to the gym; we partnered with Your Trainer to bring personal training and exclusive workouts to your smartphone and tablet.

Guest favourite
A woven tray is placed on a spacious bed, featuring a bottle of wine and two empty glasses. The bed is dressed in crisp white linens, while a pendant light hangs above, complementing the serene atmosphere of the room.
Hotel room in Jacksonville
4.94 out of 5 average rating, 104 reviews

Charming downtown hotel above wine bar - Room 3

Modern one-bedroom hotel room in a completely renovated historic building in downtown Jacksonville. Old charm with all new amenities. Rainfall shower, king bed, workspace, smart tv, free high-speed WiFi, free parking, & access to lovely downtown. Stay comes with complimentary access to TLS Works, a modern co-working space on the first floor. Plus, you’ll be steps away from The Little Stove, an Italian Market & Wine bar in the front half of the building.

Superhost
Hotel room in New Orleans
4.88 out of 5 average rating, 225 reviews

Downtown New Orleans Stay | On-Site Dining & Gym

Stay in the heart of New Orleans, perfectly placed in the French Quarter overlooking the Mississippi River. Just steps from Bourbon Street, Canal Street, and Jackson Square, this upscale hotel offers spacious rooms with city or river views, on-site dining, and a 24/7 fitness studio. Ideal for both leisure and business, you’ll enjoy easy access to New Orleans’ lively music, dining, and cultural scene while unwinding in signature comfort.

Superhost
The room features a spacious bed with crisp white linens, accompanied by a decorative blue bolster pillow. Natural light pours in through large windows, highlighting a modern sitting area with a sleek chair and vibrant blue rug. A stylish work desk complements the contemporary design.
Hotel room in New Orleans
4.84 out of 5 average rating, 289 reviews

Boutique Hotel In The Heart Of New Orleans | Bar

A scintillating stay on Canal Street, our boutique hotel is located in the heart of the French Quarter, providing travelers with a genuine taste of New Orleans. Stroll to Bourbon Street and get lost in the dizzying nightlife, gourmet cuisine, and culture that makes NOLA such a popular travel destination. Let the good times roll and enjoy staying in one of our ultra-chic rooms or outrageous, themed suites for a sinfully great time.

Superhost
Hotel room in Chicago
4.82 out of 5 average rating, 653 reviews

A polished, modern affair on iconic Michigan Ave.

Experience an upgraded stay at Le Méridien Essex Chicago, located on Michigan Ave in the city's heart. Our luxury hotel, surrounded by iconic attractions, offers modern rooms with stunning views of Grant Park, Lake Michigan, Buckingham Fountain, and the Museum Campus. We're committed to making your stay in the Loop unforgettable.

Guest favourite
A designated work area is highlighted by a wooden desk with a mirror above it. A comfortable black office chair is positioned in front of the desk. Decorative flowers are displayed in a vase, and a coffee maker is visible beside the desk. The room features neutral wall colors and a patterned carpet.
Hotel room in Laurel
4.82 out of 5 average rating, 228 reviews

Boutique Hotel Pinehurst Gateway to Laurel 205

Enjoy easy access to popular shops and restaurants from this charming place . Downtown Laurel is such a beautiful city that's the epitome of southern hospitality. This property is not only classy, but each room tells a story and is named after iconic properties and places. Historic pictures are displayed throughout the property.

Superhost
The spacious studio suite features a king bed with a blue accent wall and modern lighting. A comfortable seating area includes a sofa with a vibrant throw. Large windows allow natural light, and a small dining table is positioned nearby, complementing the light hardwood flooring.
Hotel room in Hot Springs
4.86 out of 5 average rating, 150 reviews

The Hamilton Studio King with Sofa Bed Resort View

This ground-floor studio suite rests just off the lake (not directly on the water), boasting beautiful patio lake views, at-home essentials, and direct access to Lake Hamilton, making it the perfect home base for a retreat with your partner or small family! Bedroom: 1 king bed | Living Room: Sofa w/queen pull out bed

Top guest favourite
A spacious bedroom features a large bed with a quilted cover and decorative pillows. A green velvet couch sits nearby, complemented by a floor lamp. Natural light enters through a window framed by flowing curtains, while a mirror and artwork adorn the walls.
Hotel room in Blackwater
4.97 out of 5 average rating, 100 reviews

Cozy Coffee Shop Stay!

You won’t want to leave this charming, one-of-a-kind place. Located above an award winning coffee shop in beautiful, picturesque Blackwater, MO. This 1 bed, 1 bath rental is located in a historic building. This is an old building so it will have imperfections, but what it lacks in perfection, it makes up for in charm.

Guest favourite
A two-person wooden soaker tub is set against a backdrop of warm, natural wood paneling. The tub features a smooth, curved design and is equipped with chrome fixtures. A folded white towel rests on the edge, with a wooden rack holding toiletries nearby.
Hotel room in Washington
4.92 out of 5 average rating, 207 reviews

American Bounty: Upper Patio Access

This large room features patio access, a two person wooden tub and a separate glass shower. It is located on the second floor over our quaint wine bar and overlooks the Missouri River. Just steps from our Historic downtown riverfront community with plenty of bars, restaurants, and charming shops to explore.

Popular amenities for Mississippi River hotels

Destinations to explore