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House holiday rentals in Santa Cruz County

Find and book unique houses on Airbnb

Top-rated house rentals in Santa Cruz County

Guests agree: these houses are highly rated for location, cleanliness and more.

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Guest favourite
A well-maintained yard features mature trees providing shading, with a spacious lawn that stretches towards the hacienda. The structure's exterior is characterized by a traditional design, complemented by a covered porch area. Clouds drift in the sky, hinting at a serene atmosphere.
Home in Arivaca
4.86 out of 5 average rating, 118 reviews

Private Getaway: Pandora Ranch House in Arivaca

Pandora is a private remote hacienda located on 20 acres in the high grasslands of the Sonoran Desert with 6 bedrooms, 6 bathrooms, a fully equipped kitchen, a dining room, living room. A well maintained yard with mature trees and charcoal BBQ grills invites to enjoy time outside. Minutes away from the quaint town of Arivaca, Buenos Aires Wildlife Refuge, Arivaca Lake and the Coronado National Forest Pandora offers easy access to hiking, boating,fishing, bird watching and off road exploration.

Top guest favourite
The spacious ranch house is situated on a gravel driveway, surrounded by green grass and gently rolling hills. A clear blue sky with wispy clouds serves as a backdrop, highlighting the peaceful rural setting and bringing attention to the home's exterior features.
Home in Sonoita
4.94 out of 5 average rating, 102 reviews

McFitz Guest Ranch

McFitz Ranch House is fully remodeled and available. Its a 3000 sqft 4 bedroom 3 bathroom w/ two master suites, and game room on 5 acres of beautiful horse property. Close to many attractions such as several wineries, brewery, the Sonoita rodeo grounds, Parker Canyon and Patagonia Lake, La Cienega Preserve and more. This location is ideal for Wedding Parties, Wine vacations, Rodeo, Kentucky Derby Fans, bird watching the Santa Cruz County Fair, hunting seasons or family weekends to the lake

Top guest favourite
A serene landscape features rolling mountains bathed in warm light from a setting sun. The view encompasses lush greenery and a dirt path leading to a guest house nestled among the hills, highlighting a peaceful rural retreat.
Home in Patagonia
5 out of 5 average rating, 36 reviews

Serenity, Starlink and waking up with bird songs

Wake up to nothing but bird sounds, enjoy morning coffee and the bright stars in dark nights on the covered patio. Contemporary furnished, spacious guest house with beautiful Mountain Views, in rural location, but close vicinity to the towns of Patagonia and Sonoita. Open kitchen - dining area floor plan. The house is set up with all amenities needed by seasonal visitors and remote working professionals. No pets. A small dog may be ok. 1 month or longer preferred. Shorter stays on request.

Guest favourite
A stylish living area features a large flat-screen TV positioned above a modern fireplace. A comfortable tan sofa and armchairs are arranged on a vibrant patterned rug. Natural light filters through the window shades, illuminating a decorative console table and colorful wall art.
Home in Tubac
4.94 out of 5 average rating, 16 reviews

Cozy 2 bedroom townhouse, Tubac

Kick back and relax in this calm and stylish space. Located in a wonderful Barrio community of Tubac. 2 bedrooms and 2 bathrooms with a nice patio overlooking the mountains. There is a nice outdoor heated pool and workout center. Close to the long and scenic Anza trail perfect for hiking and birdwatching. Walking distance to the town center and all the artsy little shops in town. Both bedrooms have comfortable queen size beds and office tables. Townhouse has a water filtration system.

Guest favourite
A southwestern-style ranch home is nestled on expansive land, surrounded by rolling plains. The structure features a white exterior with traditional architectural elements. Majestic mountains are visible in the distance under a clear sky, enhancing the serene rural landscape.
Home in Elgin
4.93 out of 5 average rating, 165 reviews

Peaceful SW-style ranch home in wine country

Welcome to our southwestern style ranch home in Sonoita/Elgin, Arizona wine country! Our home is 2,600 square feet and sits on 40 acres with unobstructed views of the beautiful Santa Rita Mountains. Our entire home is available for a wine country getaway. With three bedrooms, two full bathrooms with dual vanities, a half bath, an amazing kitchen, dining, two living spaces, and high-speed Internet, our home is ideal for two or three couples, or a family getaway (crib available for use).

Top guest favourite
A dining area features a long wooden table surrounded by six dark chairs. A large chandelier shaped like a star hangs above the table, casting intricate patterns on the walls. A decorative centerpiece of fresh fruits adds a touch of color.
Home in Tubac
5 out of 5 average rating, 142 reviews

A Tubac Getaway

Amazing luxury vacation rental in beautiful, historic Tubac, Arizona. Located in The Sanctuary neighborhood, this home is within walking distance of either The Village of Tubac or the Tubac Golf Resort. Plenty of nearby activities including hiking, golf, birdwatching, or day trips to southern Arizona. Visit unique shops in The Village of Tubac or the Resort for furnishings, jewelry, or great food at a variety of restaurants. Come see everything that southern Arizona has to offer!

Guest favourite
A spacious living area features a light-colored sofa with colorful accent pillows and a glass coffee table. Artwork adorns the walls, while natural light filters in through a window. A dining area with chairs and a modern workspace is visible in the background.
Home in Patagonia
4.94 out of 5 average rating, 109 reviews

Cottage on Santa Rita | Sundrenched 2 bd/1 bth

Nestled against the hill, this private, sun-filled home is located in the heart of Patagonia, a few quick steps to local businesses. Expansive patios and a cactus garden provide a hidden oasis behind the cottage - an ideal base for exploring the region's wineries, historic towns, gravel cycling, and forests. The home is fully updated, with a generously equipped kitchen, large master bedroom, washer/dryer, flexible second sleeping space, and tasteful minimalist southwest decor.

Top guest favourite
An open living area features a high, vaulted ceiling with exposed wooden beams. Large windows offer natural light and views of the surrounding trees. A brown sectional sofa surrounds a coffee table, while a blue storage cabinet and a television complete the space. Dining chairs and a table are visible to one side.
Home in Patagonia
5 out of 5 average rating, 84 reviews

Patagonia's Private Paradise

$100 PER NIGHT SUMMER IN PATAGONIA IS A WONDERFUL TIME SUMMER DISCOUNT READ OUR REVIEWS BEFORE YOU CHOOSE Patagonia is located high in the SKY ISLANDS of Southeast Arizona. The higher elevation and mountain forests make Patagonia much cooler than the Arizona cities at a lower elevation. Come to Patagonia and enjoy great discounts for longer-term stays at a time of year that many find nice and green. 20% OFF FOR 7 NIGHTS OR MORE 35% OFF FOR 28 DAYS OR MORE

Top guest favourite
Home in Patagonia
5 out of 5 average rating, 7 reviews

Peaceful Family Friendly + Fire Pit + Volleyball

Escape to this peaceful desert retreat nestled against the hills of Patagonia. With two bedrooms, a bonus office with daybed, and a spacious living area with pull out bed, the home comfortably hosts families or small groups looking to relax, explore, and enjoy the quiet beauty of Southern Arizona. Spend evenings under the twinkle lights around the fire pit, wake up to views of the hills, or enjoy a friendly match on the volleyball court.

Top guest favourite
A green casita is situated in an open landscape, surrounded by a rustic fence. A gravel driveway leads towards the entrance, with an American flag waving gently overhead. Lush grass and a few scattered trees enhance the rural setting under a clear blue sky.
Home in Sonoita
4.98 out of 5 average rating, 285 reviews

Sky Island Retreat Sonoita, AZ.

Sky Island Retreat is a quiet and peaceful hilltop retreat in which you can relax and enjoy the natural beauty of this historic area. The casita is the original but updated ranch house built in the late 60’s. We have kept much of its original charm while upgrading to modern comfort and conveniences. We are located on a privately gated property just minutes from the heart of Sonoita and Southern AZ’s growing wine country.

Top guest favourite
A modern kitchen area features wooden cabinetry and stainless steel appliances, including a stove and refrigerator. Natural light fills the space through the window, and a cozy dining table is set nearby. Decorative elements, such as wall art, enhance the inviting design.
Home in Sonoita
4.99 out of 5 average rating, 348 reviews

Winemaker's Casita in the heart of Wine Country

The perfect casita for your wine tasting getaway! Our cozy space is full of local charm and minutes away from Elgin and Sonoita's many wineries. Centrally located near the Sonoita Crossroads, the Winemaker's Casita is walking distance from local restaurants, including Copper Brothel Brewery and Tia 'Nita's Cantina. Owned + operated by the proprietors of Rune Wines.

Guest favourite
The exterior of the home is presented, featuring a modern single-story structure framed by desert landscaping. A gravel pathway leads to the entrance, while two trees provide a natural element. A colorful sky is visible, suggesting a vibrant sunset.
Home in Rio Rico
4.97 out of 5 average rating, 37 reviews

Large group getaway - 4 bed w/ updated appliances

Welcome to this new construction 4-bedroom, 2-bathroom home in Rio Rico! Perfect for families or groups. Enjoy an open-concept living space with a gourmet kitchen, granite countertops, and stainless steel appliances. Visit nearby attractions such as Tumacácori National Park, explore nearby Tubac & Nogales AZ, or enjoy family time by the fire pit!

Popular amenities for house rentals in Santa Cruz County