Some info is shown in its original language. Translate

Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

1 of 1 pages1 / 1
Top guest favourite
A spacious rooftop terrace features a checkered tile pattern, with seating areas and a large umbrella for shade. Panoramic ocean views are provided, showcasing multiple boats in the water and the coastal landscape, creating a serene outdoor space for relaxation.
Townhouse in Puerto Ayora
4.93 out of 5 average rating, 134 reviews

Galapagos Family Vacation 3 BR. Ocean View

This unique luxury townhouse combines high-tech amenities with spacious comfort. (First Floor) The great room features a state-of-the-art kitchen, a generous dining table, and a cozy living area with a library, high-speed Wi-Fi, and a large desk. (Second Floor) Large staterooms generously sized, air-conditioned, soundproof, impeccably clean, each with private restrooms. (Third Floor)The rooftop terrace offers breathtaking ocean views, featuring ample seating and hammocks for a perfect getaway.

Guest favourite
A cozy living area features a light-colored sofa and a teal lounge chair. A white coffee table stands in the center, with a bookshelf displaying various books nearby. The open floor plan allows visibility to the dining area and kitchen beyond.
Home in Puerto Ayora
4.91 out of 5 average rating, 94 reviews

Spacious and Beautiful Galapagos Home

This spacious and lovely home is located within a walled complex of three homes total, surrounded by beautiful gardens. When you are here you will feel like you are in your own little oasis away from everything, but still conveniently located very close to downtown. This 3 bedroom home has a large kitchen, dining room, office area, living room, garden level patio, balcony and large rooftop terrace for sunbathing or having sundowners. The surrounding lush garden makes it feel like a real getaway!

Top guest favourite
Flat in Puerto Ayora
4.96 out of 5 average rating, 85 reviews

Bright and cozy 2 bedroom home away from home

Kick back and relax in this calm, stylish space. A bright and comfortable two-bedroom apartment in the heart of the Galapagos, Santa Cruz Island. Surrounded by vegetation, it is situated only four blocks from the main street, five minutes walk from the main dock, and at the entrance of Tortuga Bay. AMAZING terrace with outside dining areas. Perfect for couples or a small group of friends. It offers working spaces, a kitchen, a washing machine, all you need to have your own home in the Galapagos.

Top guest favourite
A bright living area features large windows allowing natural light to fill the space. A white sofa sits atop a dark rug, accompanied by a wooden coffee table and an armchair. The open kitchen is visible, showcasing wooden cabinetry and modern appliances.
Flat in Puerto Ayora
4.95 out of 5 average rating, 182 reviews

Planet House Apt1: modern, spacious great location

Beautiful legally registered property, with partial ocean view and wonderful fresh breeze. Our apartment is located two blocks away from Charles Darwin Avenue. Guests can enjoy a leisurely walk to main attractions like the Charles Darwin Research Station and beach, great restaurants, cafés, shops, bike rental, dive shops, tour operators and more. Great options for guests seeking flexibility, comfort and value for money. The bedroom has AC, the living area benefits from a nice sea breeze.

Guest favourite
Home in Puerto Ayora
5 out of 5 average rating, 7 reviews

Samana Stay

Samana Stay is a spacious two-level family home in a quiet walkable neighbourhood, with beaches and the Charles Darwin Research Station nearby. Designed for comfort and long stays, it offers generous living areas, air-conditioned downstairs bedrooms, reliable Wi-Fi, and a fully equipped kitchen. The open living and dining space opens to a private garden with cut lava-rock pathways, creating a calm outdoor retreat and complete “entire home” privacy, ideal for families and eco-travellers.

Top guest favourite
A bright common area features two comfortable sofas with decorative cushions and a wooden coffee table at the center. A TV is placed on an easel, and vibrant wall art adds character to the space. The open layout is enhanced by wooden beams and pendant lighting.
Flat in Puerto Ayora
4.96 out of 5 average rating, 190 reviews

Updated apartment close to centre of town

Our private, bright, spacious apartment is centrally located in Puerto Ayora close to Darwin Avenue. Restaurants, shops, Darwin Station and the main passenger pier are just a few minutes walk away. The apartment is equipped with wifi, large kitchen with fridge, induction stovetop and microwave, and a large common area. It is good for couples, families or small groups. There are two bedrooms with A/C and sofa beds so a family group can easily be accommodated. Patio available upstairs.

Guest favourite
An airy open space showcases a wooden dining area with three stools and a brightly lit kitchen in the background. Two woven light fixtures hang from above, while a large potted plant adds a touch of greenery to the warm-toned interior.
Home in Puerto Ayora
5 out of 5 average rating, 48 reviews

Villa Náutica

Welcome to your cozy home in the Galápagos Islands! Escape to my enchanting villa loft, where my Swiss and Galápagos roots intertwine, experience the perfect harmony of vibrant island life and cozy Swiss vibes. With bright, airy interiors and unique nautical touches, my space invites you to unwind in style. Located just an 10 min stroll from the Charles Darwin Ave. I’m here to ensure your stay is magical. Come & discover the beauty of the Galápagos—your unforgettable journey awaits!

Top guest favourite
Cabin in Santa Cruz
4.96 out of 5 average rating, 208 reviews

Casa Vikingo • A Unique, Secluded Highland Cabin

Casa Vikingo blends Scandinavian-inspired design with tropical modernism, creating airy, climate-responsive spaces that immerse you in the unique highland nature of Galápagos. Under the shade of endemic guayabillo trees, the cabin blends seamlessly into the landscape while resting on a lava rock base built from materials sourced on site. The cabin offers some of the most beautiful views in the area, which you can admire directly from the king-sized bed or the private plunge tub.

Top guest favourite
The bright bedroom features two spacious beds with patterned bedding. Wooden beams add character to the ceiling while light fixtures create a warm ambiance. A large window allows natural light to fill the room, and a piece of art depicting a tree adorns one wall.
Bungalow in Puerto Ayora
4.9 out of 5 average rating, 302 reviews

Bright Garden Bungalow in a quiet neighborhood.

Sunshine filled, bright garden suite, next to the entrance to the Galapagos National Park and the Charles Darwin Station, and a few blocks away from some of the best restaurants, art galleries and bars in town. Located on the far end of one of Puerto Ayora's main streets, accessible to the road but removed enough to be isolated from the urban noise. An AC cools the suite when needed in the warmer months, and it’s screened windows are the alternative as well .

Guest favourite
Holiday home in Puerto Ayora
4.9 out of 5 average rating, 78 reviews

Suite Familiar con Jacuzzi (gratis) Photos 2026.

ペTU NUEVO HOGAR A UN PRECIO INSUPERABLE Disfruta nuestro departamento/suite con su familia o amigos en un lugar tranquilo y con una comodidad moderna y acogedora con todo incluido. Totalmente amoblado!! Totalmente personalizado para ti. Acceso a un parque en frente a su estadía ( fútbol, básquet y juegos infantiles) A tan solo 3-4 minutos en auto de las famosas playas, la Estación Charles Darwin y el Malecón.

Guest favourite
A charming exterior of a private accommodation is presented, featuring a rustic wooden door framed by lush greenery and colorful flowering plants. The natural stone pathway leads to the entrance, enhancing the inviting atmosphere of the serene outdoor space.
Home in Puerto Ayora
4.89 out of 5 average rating, 152 reviews

House El Galapagueño

Ven! Disfruta de la sencillez de este mágico alojamiento tranquilo, céntrico y Privado con tu Pareja, Familia o Amigos! Un lugar ideal para descansar después de las visitas a los sitios turísticos más extraordinarios de las Islas Galápagos!!! 🏡🐢🏞️🏝️☀️🐚 Te Esperamos!!! A 15 minutos a pie del Malecón A 100 metros de la entrada de la Playa Tortuga Bay A 20 metros de la Cancha de Tennis

Superhost
An inviting interior space is showcased, featuring light wood accents and large glass doors. A hammock is suspended between two rooms, creating a relaxed ambiance. Natural light filters through sheer curtains, illuminating the open layout with soft shadows on polished tile floors.
Flat in Puerto Ayora
4.91 out of 5 average rating, 155 reviews

Casa Tuna

Disfruta de tus vacaciones en Galápagos en un hermoso departamento ubicado en un sector residencial de Puerto Ayora , con un estilo único que combina la madera con el blanco , habitaciones confortables con TV, aire acondicionado y baño privado. Además, con una amplia terraza que harán tu estancia inolvidable.

Popular amenities for Santa Cruz holiday rentals

Destinations to explore

  1. Airbnb
  2. Ecuador
  3. Galápagos
  4. Santa Cruz