Hotel holiday rentals in Santa Cruz Island
Find and book unique hotel rentals on Airbnb
Top-rated hotel rentals in Santa Cruz Island
Guests agree: these hotel rentals are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for hotel rentals in Santa Cruz Island
Family-friendly hotel rentals
Hotel room in Puerto Ayora, Santa Cruz Island, Galapagos Islands
4.81 out of 5 average rating, 59 reviewsThe Galapagos Pearl Hotel- Balcony Room #6
24–31 Jan
Hotel room in Puerto Ayora
4.75 out of 5 average rating, 85 reviewsNelyza's Suites & Adventure
6–13 Aug
Hostel in Galápagos Islands
4.7 out of 5 average rating, 10 reviewsWhite House G.
5–12 Jun
Hotel room in Puerto Ayora
4.74 out of 5 average rating, 31 reviewsGalapagos Dreams Double
22–29 Jul
Boutique hotel in El Garrapatero
4.6 out of 5 average rating, 10 reviewsEnchanted Lodge
17–24 May
Hostel in Puerto Ayora
4.93 out of 5 average rating, 15 reviewsKING OR TWIN BEDS SUITE WITH BALCONY ON 2ND FLOOR
28 Jul – 4 Aug
Hotel in Galapagos/Santa Cruz/Puerto Ayora
4.59 out of 5 average rating, 39 reviewsGloria-Galapagos Inn_Triple
22–29 Jul
Hotel in Puerto Ayora
4.54 out of 5 average rating, 13 reviewsFamily Twin Room
22 Feb – 1 Mar
Hotel rentals with a pool
Hotel in Puerto Ayora
4.33 out of 5 average rating, 9 reviewsNatura Gardens Galapagos hotel
1–8 Feb
Hotel in Puerto Ayora
Hotel Tortuga Bay EC
18–25 Oct
Hotel room in Puerto Ayora
5.0 out of 5 average rating, 9 reviewsHotel Coloma Galapagos : Triple Room
29 Jan – 5 Feb
Hotel room in Puerto Ayora
4.75 out of 5 average rating, 16 reviewsHOTEL COLOMA GALAPAGOS : DOUBLE ROOM
13–20 Oct
Hotel room in Puerto Ayora
HOTEL COLOMA GALAPAGOS : TWIN ROOM
19–26 May
Hotel room in Puerto Ayora
HOTEL COLOMA GALAPAGOS TWIN ROOM
31 Jan – 7 Feb
Hotel room in Puerto Ayora
HOTEL COLOMA GALAPAGOS : FAMILY ROOM
30 Aug – 6 Sept
Hotel in Puerto Ayora
4.64 out of 5 average rating, 14 reviewsBudget and Cozy Double Room
22–29 May
Hotel rentals with a patio
Room in Puerto Ayora
4.63 out of 5 average rating, 24 reviewsGALAPAGOS DOVE #5
16–23 Nov
Hotel in Puerto Ayora
4.61 out of 5 average rating, 18 reviewsBeautiful oceanfront double room.
28 Jan – 4 Feb
Nature lodge in Santa Cruz
Cabañas El Eden
24 Nov – 1 Dec
Hotel in Puerto Ayora
New place to stayStandard Room at Hotel Santa Fe
6–13 Apr
Hotel in Puerto Ayora
Albatros / Deluxe Double Room
19–26 Aug
Boutique hotel in Puerto Ayora
Spacious & Comfotable Twin Room with Pool
30 Jun – 7 Jul
Hotel in Puerto Ayora
Suite matrimonial
16–23 Jan
Hotel in Puerto Ayora
Puerto Ay0ra Island Hotel
8–15 Nov
Destinations to explore
- San Cristobal Holiday rentals
- Isabela Island Holiday rentals
- Puerto Ayora Holiday rentals
- Santa Cruz Holiday rentals
- Baltra Island Holiday rentals
- Puerto Villamil Holiday rentals
- San Cristóbal Island Holiday rentals
- Puerto Baquerizo Moreno Holiday rentals
- Playa de Oro Holiday rentals
- El cascajo Holiday rentals
- Playa los alemanes Holiday rentals
- Point Carola Beach Holiday rentals
- Aparthotel rentals Ecuador
- Hotel rentals Ecuador
- Boutique hotel rentals Ecuador
- Hotel rentals Galápagos Islands
- Boutique hotel rentals Galápagos Islands
- Hotel rentals Galápagos Islands
- Boutique hotel rentals Galápagos Islands
- Rentals with outdoor seating Santa Cruz Island
- Rentals with a fireplace Santa Cruz Island
- Pet-friendly rentals Santa Cruz Island
- House rentals Santa Cruz Island
- Rentals with a hot tub Santa Cruz Island
- Rentals with breakfast Santa Cruz Island
- Rentals with pools Santa Cruz Island
- Rentals with a patio Santa Cruz Island
- Monthly Rentals Santa Cruz Island
- Smoking-friendly rentals Santa Cruz Island
- Flat rentals Santa Cruz Island
- Waterfront rentals Santa Cruz Island
- Serviced apartment rentals Santa Cruz Island
- Family-friendly rentals Santa Cruz Island
- Bed and breakfasts Santa Cruz Island
- Rentals with beach access Santa Cruz Island
- Rentals with a washing machine and dryer Santa Cruz Island
- Rentals with a firepit Santa Cruz Island
- Hostel rentals Santa Cruz Island
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom