
Guest house holiday rentals in South Carolina
Find and book unique guest house rentals on Airbnb
Top-rated guest house rentals in South Carolina
Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

Scenic Loft in the Woods
Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!
4.97 out of 5 average rating, 381 reviews
★Delightful guest house near historic plantations★
Nestled in the Historic Plantation District between Summerville & Charleston, our timberframe "bunkhouse" offers privacy, comfort & convenience. This 850+ sq ft retreat includes full kitchen & bath, 2 dbl beds, twin bed & plenty of living space. There's a private entrance, so come & go as you please (we're right next door if you need us). Minutes from Middleton Place, Drayton Hall & Magnolia Gardens, an easy drive to dntn Charleston, historic S'ville, beaches & golf courses. *Now with WiFi*
4.98 out of 5 average rating, 776 reviews
Farm Stay w Gardens, Cute Animals, Firepit + Porch
Welcome to the farm! This cute little farm studio is ready for your enjoyment! With a horse-front view and rows of flowers in sight, you will be sure to soak in all the feels of farm life, all while being close to West Ashley, 30 minutes from Downtown Charleston, and 35 min from beach access. Tucked in behind the hustle and bustle of city life, you can put your feet up and relax, walk the gardens, or check out the cute farm animals. Truly, this is a unique stay that you don't want to miss!
4.97 out of 5 average rating, 164 reviews
The James: “Tiny” Home b/w Downtown & Folly
The James is a unique 530 sq ft retro coastal tiny home located in a gorgeous neighborhood on James Island ◡̈ 10 mins to downtown Charleston 12 minutes to Folly Beach Walking distance to restaurants The James sleeps up to 6 people and 2 dogs (NO PET FEE) & boasts a private fenced yard & patio with an outdoor shower and Clawfoot tub! The James is ideal for solo travelers, couples, families, those traveling w/ their dog(s), those w/ limited mobility and groups of friends. #BNB-2023-02
4.98 out of 5 average rating, 268 reviews
Mountain Cabin on Creek at Jocassee Gorge.
Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.
4.91 out of 5 average rating, 453 reviews
Private 1/1 Old Mt Pleasant/Shem Creek Bungalow
Nestled in desirable Old Mt. Pleasant off Coleman Blvd, this quaint 1 bed/1 bath bungalow offers location and convenience. Minutes to Shem Creek and waterfront dining, just 3 miles from Sullivan's Island Beach. Enjoy sunsets from the nearby Pitt Street Bridge, or stroll just one block to bustling Coleman Blvd with restaurants, shops, and fitness. Three major grocery stores are <1 mile. Quiet, clean, and situated minutes to Downtown Charleston. STR Permit #ST260001 MP Bus Lic #BL-24-000053
4.97 out of 5 average rating, 624 reviews
The Cottage at Old Oaks Farm
Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.
4.99 out of 5 average rating, 468 reviews
Lake front Lake Murray in the Heart of Lexington
Walk out onto Lake Murray in the heart of Lexington! From sunrise to sunset this home is perfect for that relaxing get away; a private beach is steps from your door, a dock to fish from, boat ramp to launch your lake toys, quite cove with beautiful wild life! As the owners we live in the upstairs of the home (completely securely separated) and are available if you need anything! We enjoy sharing this beautiful home with others! Please note the beach, dock and lake are shared spaces.
4.97 out of 5 average rating, 176 reviews
Horse Farm in Aiken, SC
Spacious, private guest house with views on a 17-acre entirely fenced horse farm located just 14 miles from Aiken, SC and 30 miles from Augusta, GA (Masters). Our equestrian community exudes southern charm; the perfect, peaceful retreat and horse country getaway. Near to historic Downtown Aiken & Hitchcock Woods. This family-friendly farm is ideal for short, extended or corporate stays. Have horses? There's a barn with 4 stalls and 7 fenced pastures for horse turnout. Separate fee.
4.98 out of 5 average rating, 164 reviews
River Retreat- Waterfront- Less than1 MI from PI
Escape to your own peaceful waterfront retreat less than a mile from Parris Island! This 3-bedroom, 2-bath river guest home sleeps up to 8 and features breathtaking water views, a private deep-water dock, screened porch, full kitchen, and washer/dryer. Watch the sunrise over the river, fish from the property, keep an eye out for feeding dolphins, or simply relax by the water. Perfect for Marine Corps graduation families, boating and fishing trips, or a relaxing Lowcountry getaway.
4.95 out of 5 average rating, 357 reviews
Lizzi & Scott’sTiny Guest House secluded USC-Vista
Welcome to our tiny guest cottage hidden in the heart of the city. It's within blocks of restaurants, coffee shops, an art movie house, and a lovely river walk. The Lace House/Governor’s Mansion, business district, MiLB & UofSC are a short walk or bike ride away. At the rear of our home, it’s private, secure & quiet. A partition & movable screen separate the bathroom area. There’s a smart tv, small fridge, microwave, coffeemaker & work-table.24 hr self check-in.
4.9 out of 5 average rating, 1067 reviews
Stunning Couples Cottage with Creek Dock!
You will fall in love with this stunning, newly-built guest cottage nestled under the canopy of a majestic 400-year-old live oak tree! Providing ultimate comfort, convenience and serenity, this is the perfect place to launch your Charleston adventure – 10 minutes to Shem Creek, & 15 minutes to Sullivan's Island or Downtown Charleston. PLUS, come enjoy our brand new dock on the creek! A picture-perfect spot to relax and enjoy the stunning Lowcountry scenery!
4.98 out of 5 average rating, 287 reviewsPopular amenities for guest house rentals in South Carolina
Family-friendly guest house rentals

Carriage House: Studio Bed & Bath - Pool & Hot Tub
4.95 out of 5 average rating, 786 reviews
Home on the farm
4.99 out of 5 average rating, 411 reviews
Campus Cottage
4.98 out of 5 average rating, 123 reviews
Studio Apt - (Pets/beach/pool/golf)
4.95 out of 5 average rating, 307 reviews
My Happy Place
4.93 out of 5 average rating, 207 reviews
New Loft in Historic Summerville
4.89 out of 5 average rating, 917 reviews
Walk to restaurants! New, beautiful & clean home
4.98 out of 5 average rating, 124 reviews
Greenville With A View!
4.98 out of 5 average rating, 291 reviewsGuest house rentals with a patio

*Old Village/Shem Creek Charmer*NEW 2BR Guesthouse
4.96 out of 5 average rating, 196 reviews
The Lodge at Pythian Park
5.0 out of 5 average rating, 151 reviews
Shem Creek Cottage!
4.96 out of 5 average rating, 153 reviews
Spacious Guest House in Mt Pleasant *10 min to dtn
4.92 out of 5 average rating, 112 reviews
Restful Refuge
4.99 out of 5 average rating, 181 reviews
Aiken Barndominium/Studio Apt
5.0 out of 5 average rating, 149 reviews
Blessed Haven - king bed guest house
4.94 out of 5 average rating, 131 reviews
Hearts & Dreams Peaceful Family Retreat w/ pool
4.99 out of 5 average rating, 101 reviewsGuest house rentals with a washing machine and dryer

Buddy's Cottage near everything in Beaufort, SC
4.98 out of 5 average rating, 404 reviews
The Cottage @JustA'MereLodge
5.0 out of 5 average rating, 146 reviews
Large Guesthouse with Private Dock & Marsh Views
4.98 out of 5 average rating, 253 reviews
Private-Lake getaway-7 mile view from dock
4.94 out of 5 average rating, 218 reviews
Modern Cottage in Peaceful and Central Location
4.99 out of 5 average rating, 288 reviews
Upscale Couple's Escape | Beach & Downtown CHS
4.97 out of 5 average rating, 354 reviews
Adorable 2 bedroom guesthouse in Bowman, SC.
4.92 out of 5 average rating, 103 reviews
Camden Coach House Long term stay southern balance
4.91 out of 5 average rating, 387 reviewsDestinations to explore
- Motorhome rentals South Carolina
- Townhouse rentals South Carolina
- Farm stay rentals South Carolina
- Cabin rentals South Carolina
- Dome rentals South Carolina
- Family-friendly rentals South Carolina
- Tiny house rentals South Carolina
- Treehouse rentals South Carolina
- Serviced apartment rentals South Carolina
- Beach apartment rentals South Carolina
- Resort rentals South Carolina
- Loft rentals South Carolina
- Nature eco lodge rentals South Carolina
- Rentals with an accessible-height bed South Carolina
- Rentals with an accessible-height toilet South Carolina
- Beach house rentals South Carolina
- Rentals with breakfast South Carolina
- Rentals with a sauna South Carolina
- Rentals with pools South Carolina
- Tent rentals South Carolina
- Luxury rentals South Carolina
- House rentals South Carolina
- Boat rentals South Carolina
- Bed and breakfasts South Carolina
- Lakehouse rentals South Carolina
- Beachfront rentals South Carolina
- Rentals with lake access South Carolina
- Cottage rentals South Carolina
- Aparthotel rentals South Carolina
- Rentals with a kayak South Carolina
- Ski-in/ski-out rentals South Carolina
- Villa rentals South Carolina
- Boutique hotels South Carolina
- Holiday home rentals South Carolina
- Hotel rooms South Carolina
- Rentals with a hot tub South Carolina
- Rentals with beach access South Carolina
- Waterfront rentals South Carolina
- Campsite rentals South Carolina
- Hostel rentals South Carolina
- Pet-friendly rentals South Carolina
- Barn rentals South Carolina
- Flat rentals South Carolina
- Private suite rentals South Carolina
- Apartment rentals South Carolina
- Guest house rentals United States
- Things to do South Carolina
- Wildlife South Carolina
- Cooking South Carolina
- Food tours South Carolina
- Cultural tours South Carolina
- Outdoors South Carolina
- Landmarks South Carolina
- Tastings South Carolina
- Art workshops South Carolina
- Water sports South Carolina
- Things to do United States
- Shopping and fashion United States
- Dining United States
- Museums United States
- Cultural tours United States
- Architecture United States
- Workouts United States
- Flying United States
- Art workshops United States
- Wellness United States
- Food tours United States
- Wildlife United States
- Landmarks United States
- Water sports United States
- Performances United States
- Tastings United States
- Galleries United States
- Cooking United States
- Beauty United States
- Outdoors United States





