Holiday rentals with a patio in Cape Girardeau County

The White House, Located Near SEMO. Historical Gem

Great for family or group vacations and holiday gatherings. Historic charm with large rooms and high ceilings with all the comfort and amenities of a brand new home. Plenty of off street parking. This spacious and unique historic home is completely renovated; like new inside and out. 2 minute drive to SEMO University and the Cape Catfish. Within walking distance to Mercy Hospital and The Pickleball Factory. Centrally located to most of Cape Girardeau. Close to downtown dining and entertainment.

Cape Charm: 3 BR Close to SEMO & Mercy! CLEAN!

Cape Charm is a "charming" 3 BR home in a safe, quiet neighborhood perfectly located next to SEMO, Mercy Hospital, Capaha Park & the historic district - all less than a 7 minute walk! Feel at home in a magnificently cute 3 bedroom home (w/king bed), fully equipped kitchen, living room, dining room, bathroom, & sun room. Free, fast WIFI, a smart TV in the living room & bedroom. It's centrally located to everything! We are experienced hosts with highly rated listings in Florida and Missouri.

Historic Riverside Getaway

Step into a beautifully restored early 20th-century gem, where classic architecture meets cozy, modern interiors. Sip your morning coffee on the balcony with river views, unwind in a stylish lounge, and enjoy the warmth of wood floors, plush rugs, and curated decor. With a full kitchen, spacious bathroom, and serene bedroom, this space is perfect for couples, solo travelers, or remote workers seeking peace and character. Book your stay where comfort and charm meet right in the heart of downtown

Lorimier Loft Gallery next to SEMO River Campus

Directly across from Southeast Missouri State University’s River Campus, Lorimier Loft Gallery features luxury accommodations, purchasable gallery artwork and easy access to historic downtown Cape Girardeau. Every inch of this space delivers an aesthetic experience from the artwork to the tile-work to the location: Cross the street for performing art at the River Campus. Sit on the porch and listen to the marching band practice. Curl up by the fire and soak in a rich gallery during your stay.

A-Frame tiny home in tiny home village

Enjoy nature as you stay in our unique tiny home village. Nestled between Boulder Creek and lovely natural rock formations, we are proud to share our beautiful property. The Mermaid is our bright yellow A-frame with a porch enveloped in nature featuring our Mermaid benches. With two bedrooms (both w/ queen beds), one bathroom and a futon in the living area, the Mermaid sleeps up to 5 people. The unit has a small kitchenette with a larger mini fridge, microwave, hotplate complete with dishes.

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Guesthouse w/ pool, outdoor fireplace, game room

Bring the whole family to this great place with lots of room for fun and located in a quiet country subdivision with beautiful sunsets and Missouri wildlife. Enjoy a fire and s’mores in the outdoor fireplace or sit by the propane fire feature in the high-top table. All S’more essentials are provided. Amenities are numerous, including full-sized washer and dryer for guest use. Game room has Pac-man arcade, ping pong, pool table and air hockey. No parties, no smoking, no pets allowed.

Gorgeous 1856 Log Cabin, Completely Renovated

Rusted Route Farms is a history rich farm that is nestled in the country. Originally built as a homestead, it boasts a spring fed pond, creek, a 1900's Sears Crafted Barn now used for weddings and events. A porch laced around its front. Large back patio with a grill, fire pit and out door fireplace. A lofted ceiling extended from its roof where the house once had an open-air center breezeway. The open floor plan makes connecting a dream. You'll fall in love with this cabin!

Log Cabin w/ Hot tub - Near Casino & Downtown Cape

THE BEST GETAWAY HERE IN CAPE! Have a relaxing staycation here in Cape Girardeau Perfect for a QUICK GETAWAY for couples, families or friends 5 MINS to the casino, country club and downtown cape Very unique log home with a private bedroom queen size bed, pull-out queen size futon in the living room and twin size hide away SLEEPS 4. Pool table, darts, and a hot tub.There is a large deck and fire pit which has the feel of being in the woods.

The Wooded Walnut House

Escape to our charming home nestled among majestic walnut and oak trees on a spacious lot in Cape Girardeau! We've created a welcoming retreat that combines the tranquility of nature with unbeatable convenience - complete with a lovely deck and patio for outdoor relaxation - just minutes from historic Downtown Cape Girardeau, Southeast Missouri State University, and Capaha Park (home of SEMO and Cape Catfish Baseball).