
Family-friendly holiday rentals in Clayton
Find and book unique family-friendly homes on Airbnb
Top-rated family-friendly rentals in Clayton
Guests agree: these family-friendly homes are highly rated for location, cleanliness and more.

Large U. City Apt 4 BR, 2 Bath, Pool, near Wash U.
Deb and I welcome you to our newly renovated charming U City first floor apartment - your home base to explore the best of St. Louis neighborhoods. Close to Wash U & Metro link. Minutes from Forest Park, Zoo, Loop, and Clayton - just 12 min to downtown. Choose from dozens of nearby restaurants or stay home and cook in the spacious kitchen. Lounge by the large pool open June through September. In unit washer/dryer. Park with playground and public tennis/pickleball courts across the street.

Modern Condo on Delmar Loop; Central to Everything
This absolutely stunning condo in the Delmar Loop are has everything you could need. Located only 100 feet from Delmar and a short walk to WashU Campus or Forest Park. Metro Link is only a 10 minute walk away. Perfect for visits to WashU for college visits and graduations! The Pageant and Delmar Hall making this the perfect condo to stay in to see your favorite band! One off-street parking spot in a gated parking lot. The entire condo community is gated & equipped with video surveillance.

Dogtown Century home near Forest Park & Maplewood
Our historic home has lots of natural light and high ceilings. The two bedrooms are furnished with comfy queen beds. The sunroom also doubles as a third sleeping room. Enjoy a morning cup of coffee on the large front porch, or yard games and bbq in the fenced back yard. The updated kitchen comes fully equipped with everything you need to help you feel right at home. Minutes from Forest Park, BJC and SSM hospitals, universities, downtown, many great restaurants and shops. Furry friends welcome!

3-bdrm apt near Pageant, Wash U, Forest Park, Loop
Three bdrm, top floor apt. with private entrance in our home. Roomy, comfy, well-furnished with everything you need. Walk to Pageant, Delmar Hall, WashU, Blueberry Hill, Salt&Smoke, MagicMiniGolf. CVS, grocery, restaurants and shops on the Delmar Loop. Or stroll our leafy streets to Forest Park, built 1904 for a World’s Fair, now a first-class museum, zoo, golf course, boat rental. Easy access via metro train or Uber/Lyft to airport, baseball, hockey, live music clubs, City Museum, the Arch.

Tranquil three-bedroom home in central St. Louis
Welcome to Spa 7748! Relax and enjoy the quiet, tranquil space we have to offer you. Three bedrooms, two full baths, laundry room, work out area, media/office area, fully equipped chef’s kitchen, two fireplaces, covered patio, outdoor fire pit, driveway parking, and street parking. Centrally located in University City, which is just minutes from the downtown Clayton business/entertainment district, Washington University, Fontbonne University Downtown STL, Central West End, The Grove, Dogtown.

1 BR Loft Near Central West End, Walk to BJC
Welcome to loft luxury, walking distance to BJC, nightlife, metro station, & Whole Foods! This space includes garage parking, in-unit W/D, and everything to stay a night or a month! Other great features: - High ceilings & huge windows - Pullout couch - 55" TV - Workspace w/ fast wireless internet - Fully-equipped kitchen - Queen memory foam bed *Please note, this loft's bedroom walls don't extend to the ceiling & there is no door. Please check photos to ensure the space meets your needs!

The Rabbit Hole
A beautifully decorated 450 sq ft space with Douglas fir bead board ceiling, fully functioning kitchen with gas range/oven and fridge; 50 inch TV that swivels 180 degrees for viewing in bed, common area and kitchen. Located across the street from Tower Grove Park (great for a morning run) & 2 blocks from the Mo Botanical Gardens. Located in the Historic Shaw neighborhood and within 5 miles of almost every major Saint Louis tourist attraction including downtown Saint Louis. Private patio

ZOO, Wash U, close to Clayton,Parking & Safe!
This completely rehabbed light and airy home is located one mile from the World Famous Forest Park Zoo, Washington University and conveniently located to Highway 64/40. Enjoy a ten minute commute to downtown or Clayton, MO. Take advantage of walking to local restaurants, theaters, parks and grocery stores. This home is the perfect get away for family vacations, graduations and local events. Convenient off street parking, full kitchen and laundry available. Very safe neighborhood!

Great Fam Friendly Home w/ Lrg Deck & Yard
**FAMILY FRIENDLY** (See details for the items avail for families) This 2 bedroom home has everything you need for a relaxing trip! Fully updated with stylish and comfortable furniture and decor. Fully equipped kitchen and an amazing backyard/deck. Quiet street by one of the best Mexican restaurants in St. Louis - Hacienda - (can walk 2 min there) Close to everything! 13 minutes to the St. Louis Zoo 10 minutes to The Magic House 15 minutes to Busch Stadium & Union Station

Weaver Guest House
This charming, light-filled cottage feels like its own private hideaway, yet it's close to everything St. Louis has to offer. Tucked between trees in a quiet Maplewood neighborhood, it's a 15-minute walk to the MetroLink and a 10-minute drive to Washington University, Webster University, Fontbonne University, Forest Park, and Clayton. Business travelers and families alike will appreciate the washer/dryer, fast WIFI and cable TV.

Large, Woodsy, Warm and Inviting | Cozy 2BR Apt
Tucked in a quiet neighborhood near the Delmar Loop, this 2-bedroom, 1-bath apartment offers a stylish and comfortable retreat. Enjoy a fully stocked kitchen with stainless steel appliances, a record player, and a 55” Google TV for streaming. Step outside to a shared patio with seating, outdoor dining, and a kids’ playground. Additional amenities include a dedicated workspace and in-house washer/dryer.

Unit 1 Rest in Comfy 2 Bdrm Well-Kept Airy Suite
Nested in private cul de sac, your immaculately spotless, spacious, bright, Central St Louis nook will pamper you with fresh, clean, comfy bedding, a recliner, a reclining sofa, a washer/dryer/iron, and a cozy kitchenette. We are just 8 min from the airport, and close to a local playground, tennis, golf, ice skating, Clayton, Wash U, Barnes/Children's Hospital
Popular amenities for Clayton family-friendly rentals
Family-friendly home rentals with a hot tub

“HOT TUB” Oasis in the heart of the city!

Lux! Hot Tub. Game Room. Sauna. Fitness. Fire Pit.

*HotTub* The Jewel on 5th-2br2b-near Historic Main

Spacious home with entertainment room and hot tub

Roomy Oasis with hot tub on the Hill!

Cozy winter ranch on wooded land near shopping

Secluded Lakeside Lodge Minutes from St. Louis

Romantic tiny home w/ hot tub
Family- and pet-friendly home rentals

Dogtown: The Place to Be near the Zoo, Wash U, BJC

2S · Safe Neighborhood Stl-Botanical Apt.Frst Park

The Little House.

Centrally Located Mid-Century Modern Retreat

New: Cozy Cottage Near The Hill

Cozy, Family Friendly at Zoo & Forest Park

Stylish Retreat | Cozy Apt. near Top Attractions!

1 Level House *Ucity near Loop/Wash U *Pets *Kids
Family-friendly home rentals with a pool

Private indoor pool & sauna

Welcome to your ideal stay!

Arch View Luxury: Hottub-Pool-Sauna-Wine &Brkfst

Spacious Home - Heated Pool Open - Amenity Packed

Resort Style Burb Suite 20mins/DT/Extended Stays

The Icon | 1BR | Rooftop Pool + King Bed + WD

Cozy 4 BR/2 Bath Home South of Downtown St. Louis

Secluded Property w Pool and Hot Tub
Quick stats about holiday rentals that are family-friendly in Clayton

Total holiday rentals
Explore 10 holiday rentals in Clayton

Nightly prices starting at
Clayton holiday rentals start at £52 per night before taxes and fees

Verified guest reviews
Over 1,040 verified reviews to help you choose

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wifi availability
10 of Clayton holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Clayton rentals

4.7 Average rating
Clayton stays receive an average rating of 4.7 out of 5 from guests
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- Busch Stadium
- Central West End
- Six Flags St. Louis
- Enterprise Center
- Saint Louis Zoo
- St. Louis Aquarium at Union Station
- City Museum
- Missouri Botanical Garden
- Gateway Arch National Park
- Hidden Valley Ski Resort
- The Dome at America's Center
- Castlewood State Park
- Washington University in St Louis
- Gateway Arch
- Cathedral Basilica of Saint Louis
- Forest Park
- Saint Louis Science Center
- Saint Louis University
- Stifel Theatre
- Missouri History Museum
- Fabulous Fox
- Laumeier Sculpture Park
- The Pageant
- Soulard Farmers Market




