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Places to stay near Cleveland Museum of Natural History

Book unique holiday rentals, homes and more on Airbnb

Top-rated holiday rentals near Cleveland Museum of Natural History

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
An outdoor space features two hot tubs surrounded by a stone pathway, illuminated by soft, warm string lights. A neon sign adds a pop of color to the brick wall, enhancing the ambiance for relaxation. The area is accentuated by green foliage in the background.
Flat in University Circle
4.99 out of 5 average rating, 150 reviews

Cle Rocks-Little Italy! W Massage chair/Hot tub #1

Fall in love with this charming, newly updated 1-bedroom, 1-bath upper unit triplex apartment situated just minutes from downtown and University Circle. Complete with a well-equipped kitchen, Smart TV, laptop workspace, and modern furnishings, this vacation rental delivers all the essentials so you can spend more time relaxing and exploring. Nearby Case Western University, UH Hospital, University Circle, Cleveland Museum of Art, Cleveland Clinic, Severance Hall, Botanical Garden, and much more!!

Top guest favourite
A living area features a comfortable sofa and two accent chairs. A rustic wooden coffee table is placed at the center, surrounded by simple decor such as woven baskets and potted plants. Exposed brick walls add texture to the cozy space, illuminated by recessed lighting.
Flat in University Circle
4.98 out of 5 average rating, 105 reviews

Little Italy 3, close to Cleveland Clinic, CWRU

Enjoy a uniquely styled experience at this boho-chic apartment in the heart of Little Italy. Exposed brick walls, hardwood floors, and wooden furnishings combine to give this apartment a boho-chic aesthetic. Enjoy dinner in the cozy kitchen and watch TV while relaxing on the comfortable sofa. One flight of stairs is leading up to the second floor (17 steps)The unit is on a quiet side street in walking distance to the heart of Little Italy (restaurants,cafes, shops).Free parking on premises(1car)

Top guest favourite
A modern kitchen is seen, featuring white cabinetry and a wooden island with seating for two. Pendant lights illuminate the space, which includes stainless steel appliances, open shelving with decor, and a black sink. Light-colored walls complement the warm wood flooring.
Home in University Circle
5.0 out of 5 average rating, 107 reviews

In the heart of Little Italy! Free Parking! 3BR-UP

Enjoy your stay at this centrally located - upper unit- in a two-family home in Little Italy. Apartment is complete with a well-equipped kitchen. The living room includes comfortable seating for 6, a smart TV, 3 poufs & coffee table - so that ALL may rest their feet from a long day, modern furnishings and a washer/dryer/linen closet. Each bedroom includes USB plugs in the lamps, alarm clocks with sound machines, blackout curtains, ceiling fans, Smart TVs, "ultra-quiet" ACs, desk, chair & mirror.

Top guest favourite
A modern kitchen area features gray cabinetry and a stainless steel sink, complemented by a sleek, dark countertop. A black stove and microwave are seen, alongside a refrigerator with a textured finish. White tiles line the backsplash, reflecting light from the overhead fixture.
Home in University Circle
4.93 out of 5 average rating, 388 reviews

Historic Little Italy Garden Apartment

Stylish garden apartment. This retreat blends modern comfort with the vibrant cultural charm of Historic Little Italy. Steps away from shops, restaurants, and lively bars. Wade Oval Park is a nearby cultual hub, home to The Art & Natural History Museums and Botanical Gardens. Easy access to Case Western Reserve, Cleveland Clinic and University Hospital. Walk to the beautiful Lakeview Cemetary or take transit downtown to 4th street. Perfect for short or long stays. Book for a memorable time.

Guest favourite
Flat in University Circle
4.91 out of 5 average rating, 134 reviews

Little Italy Two Bedroom w/ Private Drive & Patio

Stay in the heart of Cleveland's historic Little Italy, one of the city's most vibrant and walkable neighborhoods. Restaurants, cafés, bakeries, galleries, and local markets are just steps away. Whether you're visiting Cleveland Clinic, University Hospitals, Case Western Reserve University, or exploring University Circle and Downtown Cleveland, you'll enjoy a stylish first-floor apartment with two private parking spaces, a fully equipped kitchen, a private patio, and room for up to six guests.

Superhost
Home in Cleveland
4.91 out of 5 average rating, 23 reviews

Blue Historic House by Cle Clinic, CWRU, Museums

Entire private house near Cleveland Clinic, ideal for families, travel nurses, and business travelers. 10-min walk to Cleveland Clinic with quick access to University Hospitals, Case Western, Little Italy, museums, and downtown Cleveland. 3BR house + sofa bed in living room, dedicated workspace, full kitchen, washer/dryer, free parking, fast Wi-Fi, private backyard, and self check-in. Quiet, clean space for short or extended stays, including monthly stays. Green house next door also available.

Superhost
An entertainment space features a vibrant red pool table with cues resting along the side. Wooden bar stools line a bar area, while a large television is mounted on the wall opposite cozy seating. Vintage decor and soft lighting create an inviting atmosphere.
Home in University Circle
4.58 out of 5 average rating, 65 reviews

The CLE Cornerstone-Entertain & Sleep Large Groups

The Cornerstone offers a spacious retreat for large groups seeking comfort and entertainment. With 7 bedrooms (including 2 on the first floor), 4 full bathrooms, and 3 indoor entertainment spaces, dinning places for 18 people, parking for 6 cars, it’s perfect for large groups of extended families, friends, or coworkers. Luxury bathrooms with spa showers and towel warmers elevate the experience. This home ensures plenty of space to gather while maintaining privacy and relaxation for all.

Top guest favourite
A cozy living space features a genuine leather couch paired with an accent chair and a glass coffee table. A large wall-mounted TV is visible, and a houseplant adds a touch of greenery. Sliding barn doors lead to a bedroom area and dining space beyond.
Home in University Circle
4.96 out of 5 average rating, 50 reviews

Mid-Century Modern Retreat in Little Italy

Nestled in the vibrant yet peaceful and safe Little Italy neighborhood of Cleveland, this newly remodeled Mid-Century Modern style 2bed/1bath Lower unit is within walking distance to the best Cleveland has to offer. Enjoy a stroll to Case Western Reserve University, University Circle, the Cleveland Museum of Art, Cleveland Botanical Garden, and more. Discover local shops, bakeries, and renowned restaurants that give Little Italy its charm. The RTA redline station is a five minute walk.

Superhost
Flat in Cleveland
4.81 out of 5 average rating, 57 reviews

Cle Suites 1BR/1BA | 5 min Walk to Cle Clinic #6

Fully furnished luxury apartment that has been completely renovated combining old-time 19th century charm with modern amenities. Just move in with your suitcase! Within walking distance to the Cleveland Clinic Campus (5 min walk from main hospital). It’s also near University Hospitals, CWRU, Great University Circle, Downtown Cleveland, and Little Italy. This location is perfect for those receiving medical treatments and their families, doctors on rotation, travel nurses, and interns.

Top guest favourite
A welcoming entrance leads to a sunny sitting room featuring a blue sofa beside a wooden rocking chair. A small side table with a lamp is visible near a large window framed by soft curtains, allowing natural light to enter the space.
Guest suite in Cleveland Heights
4.96 out of 5 average rating, 545 reviews

Private Victorian suite with two rooms and a bath

You’ll love this newly remodeled third floor suite in our large century home located near Coventry Village/University Circle/Cleveland Clinic. The private suite with separate entrance and stairs has an air conditioned large bedroom with a firm queen bed, a sunny sitting room with a futon and a bathroom (shower) finished in Victorian ornate wood trim! Off street parking is in the rear. Our place is great for couples or business travelers, and the futon can sleep a child on.

Superhost
A spacious living area features a modern sofa facing a wall-mounted 4K HDR Smart TV. Light streams through three large windows, illuminating the warm hardwood floor. A round glass coffee table is positioned centrally, enhancing the open feel of the room.
Flat in University Circle
4.68 out of 5 average rating, 44 reviews

Cozy Condo l Minutes from Cleveland Clinic

Our apartment is ideally located near Cleveland Clinic, making it perfect for medical professionals, patients, and families. You’ll also be minutes from the Health Education Campus, Case Western Reserve University, University Hospitals, and the museums of University Circle. Enjoy a short drive to the charming Little Italy neighborhood, filled with authentic Italian restaurants, cafés, and bakeries, while downtown Cleveland is just 5 miles away for dining and entertainment.

Guest favourite
A light-filled bedroom features a comfortable bed with a checked comforter and a yellow accent pillow. The space includes a chair and desk, with a cozy sitting area visible through an open door. Bright curtains frame the windows, illuminating the warm wood floor.
Flat in University Circle
4.83 out of 5 average rating, 128 reviews

2BR in Little Italy, 5 min walk to Case & UH

Enjoy a stylish experience at this centrally-located place in the heart of Little Italy. Newly renovated with a minimalist design. You are just down the street from restaurants, bakeries and bars. The RTA redline is also a two minute walk away, which takes you straight downtown as well as to the airport. Also within walking distance of Cleveland Clinic and University Circle. The apartment is located on the first floor. There is no private parking at the property.

Popular amenities for holiday rentals near Cleveland Museum of Natural History