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Holiday rentals in Isthmus of Panama

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Isthmus of Panama

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira
4.97 out of 5 average rating, 113 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Guest favourite
A tranquil outdoor area is depicted, featuring a small private pool surrounded by lush greenery. The charming cottage stands nearby, characterized by large windows and a covered porch that offers ample natural light.
Guest house in Panamá Oeste
4.8 out of 5 average rating, 187 reviews

Cabaña de montaña con piscina privada en Panamá

Disfruta de la paz y la naturaleza en esta acogedora y equipada cabaña, perfecta para desconectar y relajarte. Rodeado de bosques y con vistas espectaculares, aquí podrás respirar aire puro y contemplar las estrellas. ✔️ Ideal para parejas, familias o aventureros. ✔️ Senderos, ríos y miradores cercanos. ✔️ Espacios cómodos y equipados para tu confort. - Capacidad de 4 personas. - Descuento a partir de dos noches. Cerca a: Laguna de San Carlos, Valle de Antón, playas del Pacifico Panameño.

Top guest favourite
An open living space features a wooden dining table surrounded by six wicker chairs. Two hanging hammocks are displayed on the covered terrace, offering views of the lush hills. Large glass doors reflect the greenery, blending indoor and outdoor spaces harmoniously.
Cabin in Torio
4.97 out of 5 average rating, 186 reviews

Cozy open space, unique jungle views, river access

An open-style jungle home with mesmerizing treetop and mountain views. Located 10 minute walk to the beach, with a trail that leads to the River. The house is not childproof! It has three individual bedrooms, each with its own key. The price is based on the number of guests. The entire house is always yours. The house offers fiber optic WiFi and two dedicated workspaces. The property is surrounded by large trees, naturally keep the house cool and provide shelter for birds and wildlife.

Top guest favourite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonome
4.98 out of 5 average rating, 133 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Top guest favourite
Loft in Panama
4.99 out of 5 average rating, 174 reviews

Patty’s Casco 2BR Loft | Balcony & Personal Touch

“Feel at home in Casco Viejo—personally welcomed by your hosts, Patty & Rudy.” Stay in the Heart of Casco Viejo with Patty’s Casitas! Prime Casco Viejo Location | Quiet, Convenient & Charming Stay steps from restaurants, cafés, bars, and plazas—right by the El Rey boutique supermarket and the waterfront promenade. This peaceful spot is rare in Casco, tucked away from rooftop noise and perfectly located at the entrance of the neighborhood for easy in & out access!

Superhost
A tranquil dipping pool is framed by lush greenery, featuring white loungers and a large umbrella for shade. The pool area exudes a serene vibe with vibrant bougainvillea in the background, enhancing the inviting outdoor space.
Home in Taboga Island
4.94 out of 5 average rating, 217 reviews

Casa Rosie - Dream Home on Tabogá Island

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Top guest favourite
A charming wooden house is surrounded by lush greenery, featuring a wraparound porch with a wooden railing. Large windows and double doors provide ample natural light, while a surfboard leans against the porch steps, indicative of nearby ocean activities.
Cottage in Bocas del Toro Province
4.97 out of 5 average rating, 304 reviews

Rustic cottage-Ocean views/walk to surfing/Jungle

Casa Palmera is located in the quieter north/west side of Isla Carenero. Relax and watch the sunsets. Only a few minutes walk to the Carenero Surf Breaks . Restaurants are within walking distance, hike around the island, or use the kayaks and see the beauty. We are 5 minute boat taxi away from the main town of Bocas, but everything you need to make your vacation unforgettable is on this island! Drinking water included.A/C in bedrooms

Guest favourite
A private rooftop terrace overlooks the ocean, featuring a hot tub and seating area with modern chairs and a table. Umbrellas provide shade, while decorative plants add a touch of nature to the space. The view includes water and distant islands, enhancing the relaxing atmosphere.
Home in Panamá
4.92 out of 5 average rating, 164 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Top guest favourite
The modern two-story cabin features large glass windows that offer expansive views of the surrounding greenery. A spacious deck with seating is visible, surrounded by lush vegetation and natural stone pathways leading up to the entrance.
Cabin in Panamá Oeste
4.91 out of 5 average rating, 203 reviews

Altos del María Cabaña La Loma de Styria

Relájate con toda la familia en este tranquilo lugar para quedarse. Es un lugar fantástico, fresco y agradable donde puedes hacer muchas actividades ecoturísticas, la mejor opción si deseas tener una de las mejores vistas que puedas imaginar. Ideal para parejas también. Contamos con 2 habitaciones 2do piso y 2 baños. Múltiples lugares para tomar bellísimas fotografías

Guest favourite
Tiny home in Altos del Maria
4.84 out of 5 average rating, 190 reviews

Casa Arcón

This earth-sheltered studio home offers a unique and romantic escape in the mountain of Altos del Maria. Cozy space surrounded by a lush green environment, ideal for those seeking a peaceful getaway, or an affordable stay to explore the gated community's amenities. This bunker home provides an inviting haven to unwind and disconnect from the hustle of city life.

Top guest favourite
An open dining space features a large wooden table set for a meal, surrounded by chairs. Expansive windows frame a scenic view of the lush landscape and bay, allowing natural light to flood the space. Ceiling fans are visible, enhancing airflow.
Villa in Bocas del Toro
5 out of 5 average rating, 52 reviews

Private Beachfront Jungle Paradise, Snorkel, WiFi

Welcome to our beautiful home, nestled in the lush jungle and just steps away from a stunning beach and ocean. This isn’t just an ordinary Airbnb—it’s a unique retreat where you can immerse yourself in nature and enjoy the tranquility of a truly special place. We invite you to relax and make yourself at home, creating unforgettable memories in this serene paradise!

Top guest favourite
A spacious living area is illuminated by natural light streaming through large glass windows. Comfortable seating arrangements are positioned around a circular coffee table, creating an inviting space for relaxation. Scenic mountain views can be seen through the glass, emphasizing the connection with the outdoors.
Cabin in Altos del Maria
4.93 out of 5 average rating, 57 reviews

Blue Sky Lodge; la mejor vista en Altos del María

Esta cabaña de lujo en la montaña ofrece un diseño moderno, acabados de calidad y vistas panorámicas de 180° de montañas y mar. Se encuentra en una comunidad cerrada segura, rodeada de un jardín verde, con amplias ventanas de vidrio que favorecen la conexión con la naturaleza. El clima es agradable, con temperaturas entre 23°C y 28°C. .

Popular amenities for Isthmus of Panama holiday rentals