
Guest house holiday rentals in Lee County
Find and book unique guest house rentals on Airbnb
Top-rated guest house rentals in Lee County
Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

Waterfront Hideaway
This picturesque Airbnb is a hidden gem nestled along a canal, one minute boat ride to the Caloosahatchee River. The living room, bathed in natural light is perfect for taking in the scenic views. The spacious bedroom has a king-size bed, ensuring a night of blissful rest. The full kitchen is equipped with all modern appliances. Close to Sanibel & Fort Myers Beach. Bring your boat & dock it on the seawall, ready to set sail whenever your heart desires. Book now - your coastal paradise awaits!

Perfect Place for your Vacations
This Guesthouse has everything you need for your vacation, it is central located, in a peaceful and safe neighborhood and have a very well distributed space. Its located few minutes from the Caloosahatche River and the beautiful beaches of the Gulf of Mexico, it includes bicycles, kayaks, umbrella, beach chairs, fishing rods and other items that will enhance your vacation. It is also very close to highly recommended restaurants, famous shops (walmart,Publix, McDonald) and other essential places.

Kayaking Paradise • Pool . Canal front
$million home located in the heart of S Fort Myers close to EVERYTHING. Kayak out of the pet friendly fenced backyard through miles of pristine mangroves, gorgeous saltwater pool; 13 miles to Sanibel Island, 6 miles to Fort Myers Beach. Walk to Lakes Park and visit the farmers market/Wednesday mornings or walk to Castle Golf (award winning mini golf). Biking trails everywhere. Near: Walmart, restaurants; Publix and Aldi's. 1 Bed/1 bath/kitchen 1st floor unit with own entry. en la planta baja

Hezekiah's 2 Story Guesthouse with Pool
Hezekiahs Guesthouse a perfect getaway in sunny SWFL! You will be staying in the guest house with a private entrance. This property has a living room and kitchenette downstairs and a spacious bedroom with master bathroom upstairs. This Airbnb is attached to our home. You will have access to the pool and our outside grill area. Complimentary coffee, water, soda and more.. Lots of nearby restaurants and shopping. Minutes away to Fort myers or Bonita beach, FGCU and RSW Airport and Hertz Arena.

Cozy haven
Enjoy a stylish experience at this centrally-located place (close to beach) This brand new space has one bedroom with a king bed, closet and dresser, blow up queen bed mattress and pull out single couch along with additional seating. It has a tub/shower combo in the bathroom along with a washer and dryer. The fully equipped kitchen has anything you need. Has Patio/deck. Guesthouse is completely private but entrance is through the detached garage. You will have your own code to access all doors

Get Away to the Mango Cottage
Nestled on the outskirts of Historic downtown Fort Myers abides the Mango Cottage overlooking the Caloosahatchee River. The sunsets are amazing. You will enjoy the luxurious linens on the King sized bed to the relaxing patio it will delight the senses. You will be able to enjoy the 60" flat screen Smart TV! . The cottage is complete with Keurig coffee maker, toaster, microwave/convection oven and grill outside. We are minutes from restaurants and night life. This is a NON-SMOKING property.

Sleep over the water- Boathouse with Private Dock
This 1920s boathouse offers a once-in-a-lifetime stay directly over Whiskey Creek, where the gentle sound of water beneath your feet lulls you to sleep. With a private entrance, dock and waterfront views, this isn't just a room--it is an unforgettable Florida experience. This boathouse has been ungraded with all modern conveniences and is centrally located close to downtown, restaurants and shopping. Sip your morning coffee on the dock as herons and bald eagles glide across the creek.

Adorable Cottage with Heated Pool -Jaccuzi - Sauna
Come and relax in this calm, stylish space located on one acre property full of pines and fruit trees, with access to the House Heated Pool with Jacuzzi and the sauna. Modern design will make you feel comfortable. Close to Bonita, Ft.Myers, Lovers key and Sanibel beaches & fishing piers. Cottage is 12 miles away (19 km) from RSW airport, about 20 min of driving. We are happy to meet our guests, but also respect your privacy. Your comfort is our priority.

Bright, Private Studio Retreat in Cape Coral, FL
Welcome to your home away from home. This studio rental is detached from the main house, giving you absolute privacy and a quiet space to relax. The kitchenette is fully equipped with all the essentials to cook real meals. Step outside and you'll find a small private patio that's all yours, perfect for morning coffee or just getting some fresh air. You've also got your own parking spot in the driveway, so no need to stress about street parking.

Charming Carriage House in Historic Neighbourhood
This lovely carriage house backs onto the famous Edison Ford Estates making it a truly unique location- you really don’t have far to go to explore its beautiful gardens! Hit the Downtowns restaurants, bars and shops nestled within Art Deco architecture in stunning pastel colours for a real ‘Old Florida’ experience! DT is a 20 minute walk away or take advantage of the free trolley service from Nov-May 1. SWF airport 17 miles.

Carney Carriage House
We are ready to welcome you back to to the Dean Park Historic District and our charming 1920's Colonial style guest house. We hope you will enjoy its quirky layout and park like property . This ground floor guest house apartment is equipped with a queen size bed in the bedroom, reading nook, bathroom, full kitchen, 2 smart TV's and private patio. Everything you need to enjoy a relaxing Florida lifestyle!

Sunroom Bungalow Downtown Pet friendly.
Enjoy your own private oasis with a fully equipped kitchen, cozy living area, queen size bed and a private porch surrounded by garden views. Just a 10-minute walk to Downtown Fort Myers, or hop on the free trolley that stops at the end of our street every 15 minutes—easy, breezy, and stress-free.
Popular amenities for guest house rentals in Lee County
Family-friendly guest house rentals

Perfect go away!

South Fort Myers close to FGCU and beaches

Peaceful and Cozy Tiny House in Lehigh Acres

Julie’s Rivers Edge Retreat North Ft Myers

Waterfront one/two bed in-law suite -gorgeous view

Zen Yard with Cozy 1 Bedroom Private entrance apt

Luxury on the Lake

Cozy Private Studio •Pet-friendly •Great location
Guest house rentals with a patio

Pool House with Lanai & Deck

1/1 Relaxing Retreat in Sunny Bonita Springs

Beachside Living – Walk to the Water!

Adorable 1 BDRM first floor house in Bokeelia

Serene Studio Steps from the Water

Cozy Guest Suite with Private Entrance

Cozy with Private Entry Near Fort Myers & Airport

Sand shack retreat canal w/pool
Guest house rentals with a washing machine and dryer

Private guest house—minutes to the best beaches!

Downtown Fort Myers Florida - Home Away From Home

Barefoot Bungalow – Cozy 2 BR Beach Retreat

3 bedroom 2 bath heated Pool Front Guest house

Seahorse Studio

Brand-New Guest Suite with Private Entrance

Florida Cottage with Pool, off McGregor Blvd.

The Flamingo Guesthouse on CANAL
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