Boutique hotels in Mississippi

Find and book unique boutique hotels on Airbnb

Top-rated boutique hotels in Mississippi

Guests agree: these boutique hotels are highly rated for location, cleanliness and more.

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Superhost
The spacious bedroom features a king bed with a light green coverlet and decorative pillows. A large window provides natural light, accompanied by a comfortable armchair and a side table. A wooden dresser with multiple drawers is positioned against the wall, enhancing the room's functionality.
Hotel room in Vicksburg
4.8 out of 5 average rating, 45 reviews

Tennesse Williams -King Bed Heart of Downtown

Big Room, Big King Bed. Spread out in the Tennessee Williams Room at Halpino. This first floor Room offers a smart TV, seating areas and good closet space on the way to the good size bath with large, tall shower. Close to eating and gathering area. Halpino is close to downtown and the courthouse, a block and a half from Duff Green, the most affordable option in the Duff Green family of properties. You can walk down for breakfast and a tour at Duff or walk downtown for dinner or libation.

Top guest favourite
A cozy seating area is highlighted by a decorative chair upholstered in deep blue fabric. A patterned cushion enhances the comfort. A small table holds a lamp and a floral arrangement, while a round mirror reflects light, adding depth to the space.
Hotel room in Ocean Springs
4.96 out of 5 average rating, 225 reviews

Mockingbird Inn- Fern Suite

*TRUE SOUTHERN CHARM* Built in 1899 and newly renovated, The Mocking Bird Inn- Fern Suite is nestled on a LIVE OAK lined historic street. The home will surround you with a modern coastal warmth. FORT BAYOU is located next to the property so, take a stroll next door to MARBLE SPRINGS PARK for a view of the bayou and learn the history of the NATURAL SPRINGS that gave Ocean Springs its name. Just 1 block to DOWNTOWN OS GALLERIES, SHOPPING & RESTAURANTS , 1 mile to the BEACH, 2 miles to CASINO's

Guest favourite
Hotel room in Picayune
4.88 out of 5 average rating, 49 reviews

The Depot Suites Suite 203

Downtown Picayune offers a charming stay at one of our three newly remodeled suites. The festive atmosphere of our downtown life and modern boutiques will please any desire to sit back and relax. Enjoy one of our downtown restaurants and full bars with great music and often live bands. Minutes away from New Orleans or the Mississippi Gulf Coast. Sit outside on the balcony and take in a beautiful sunset. Each suite allows guest to have their own space, come and enjoy our southern charm.

Top guest favourite
A cozy seating area is shown, featuring a white couch adorned with pastel green and yellow cushions. Framed artwork is displayed on the wall above the couch, complementing the light yellow walls. Soft lighting is provided by a lamp on a nearby side table.
Hotel room in Bay St. Louis
4.97 out of 5 average rating, 268 reviews

The Happy Place

Our Happy Place is bright, cheery and very comfortable. Enjoy your morning coffee or a glass of wine in the afternoon overlooking the spacious backyard and bird feeders. Don’t be surprised by a visit from our 2 rescued Terrior pups or one of our two cats! 2 block walk to Old Town, 3 blocks to the Harbor/beach and 4 blocks to the Amtrack Station! If coming in by train we can try to set up a pickup. Our quiet Cottage is perfect for couples, singles or business travelers. Come see us!

Superhost
Hotel room in Laurel

Buzzard's Roost Inn: The Birmingham Room

Located in the heart of Downtown Laurel, Mississippi, The Buzzard’s Roost Inn is a truly one-of-a-kind place to stay. Relax in one of our Crescent Line-themed rooms before setting out to explore the charming downtown area you’ve come to love on HGTV’s Home Town. The inn is newly built on the second floor of the 100-year-old Lott Furniture Building and features unique design details you won’t find anywhere else in Laurel. The Birmingham Room features a queen bed and private bathroom.

Guest favourite
Hotel room in Ocean Springs
5.0 out of 5 average rating, 23 reviews

Heart of town, firepit, gated, room for the fam

Newly renovated, this warm & inviting 1 bedroom cottage allows a perfect retreat romantic enough for a couple ready to enjoy the night life or walks by the beach & comfortable enough to house three guests looking to experience the parades & other family-friendly entertainment. Located within walking distance to the beach, shopping, dining, festivals & galleries, the suite consists of 1 bedroom, 1 bath, separate living room w/ a futon sofa sleeper, wet bar, and walk-in shower.

The property showcases a charming Victorian home framed by lush greenery and vibrant landscaping. A stone pathway leads to the welcoming front porch, flanked by colorful plants and trees. The gazebo is visible amid the well-maintained grounds, inviting relaxation in a serene setting.
Hotel room in Iuka

The Painted Lady

An entire exclusive Victorian home built in 1859 and completely renovated to accommodate modern living in every way! This one-of-a-kind home has five bedrooms, three full baths, and three half baths. The period furniture makes this majestic house even more beautiful. The home also features a commercial kitchen and wet bar, six fireplaces, screened porch and a front porch gazebo with a fire pit. The grounds are beautifully kept with a fenced garden and lavish landscaping.

Superhost
A cozy sitting area features a white daybed adorned with soft cushions against a backdrop of exposed brick walls. Natural light filters through sheer curtains, illuminating a circular table with a decorative lamp and a charming floral arrangement. Rustic wood beams enhance the room's character.
Hotel room in Carthage
4.9 out of 5 average rating, 39 reviews

Room 1 (sleep1) Chipley's Squareview Inn & Venue

This newly renovated Boutique Inn combines old-world grandeur from the original 1929 design of the Chipley office building with modern appointments and contemporary amenities. No detail is overlooked in the rustic elegance of this charming space, featuring seven uniquely styled rooms with ensuite marble baths, and all new kitchenettes. Beautiful antiques, cozy comforts and sunlit views grace every private space.

A view of the outdoor pool area is presented, surrounded by neatly arranged landscaping and brick fencing. Several umbrellas provide shade over poolside seating. Bright flower beds with colorful blooms enhance the natural setting, while tall trees stand nearby, adding to the serene ambiance.
Hotel room in Olive Branch
4.6 out of 5 average rating, 20 reviews

Private Hotel Room 2

A charming retreat in Olive Branch, MS, just minutes from Memphis. Set on 14 acres, enjoy spacious rooms with balconies, free WiFi, and a hot breakfast. Relax by the pool, dine at Tree Top Grille. Free parking. Absolutely No pets allowed. Perfect for getaways or business. Book now or ask any questions you may have. Amenities: • Outdoor pool & fitness center • On-site restaurant & bar • Free WiFi & parking

Superhost
A charming room features a cozy bed dressed in soft, floral linens and striped blankets. A vintage wooden dresser and an inviting armchair are present, complemented by natural light filtering through sheer curtains. A decorative plant adds a touch of greenery to the space.
Hotel room in Pascagoula
4.93 out of 5 average rating, 15 reviews

Cape Cod - Grand Magnolia Suites

The Cape Cod is a Queen room loaded with New England charm! You will feel like a part of the early settlers as you relax in our antique iron bed that has been lavished with soft, fluffy linens and a hand made quilt. The antique furniture was purchased from an estate in Bar Harbor, Maine and this cozy nest would not be complete without it. This room has a private bath and vanity.

Hotel room in Ocean Springs
New place to stay

OS Hotel - Standard King

Stay in an upscale place that’s near everything you want to visit. OS Hotel features 32 rooms with an incredible courtyard featuring mural by world renowned artist HOXXOH and event space at THE GALLERY. Home to Desi Vega Steakhouse. Our boutique hotel offers a unique experience in the heart of historic Downtown Ocean Springs.

Guest favourite
A serene bedroom features a spacious bed with soft white bedding and a decorative pillow. Original exposed brick walls contrast with the bright white ceiling, complemented by a soft rug and natural light streaming through large shuttered windows.
Hotel room in Louisville
4.92 out of 5 average rating, 25 reviews

The Glover Room

The Glover Room with its original tin ceilings reaching 12 feet, exposed brick walls, and large windows are a true reflection of what used to be. This beautiful room features a queen bed with custom designed headboard, luxurious bedding, dreamy mattress and gorgeous bathroom. This room can also adjoin to The Livingston Room.

Popular amenities for Mississippi boutique hotels