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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Superhost
Apartment in Condesa
5 out of 5 average rating, 5 reviews

Designer Stay in Condesa

A warm, elegant and carefully curated apartment located in the heart of La Condesa, one of Mexico City’s most beautiful and walkable neighborhoods. Designed with organic textures, soft neutral tones, the apartment creates a calm and elevated atmosphere perfect for relaxing after exploring the city. Natural light fills every corner of the space throughout the day, highlighting handcrafted details, warm wood finishes and cozy layered textiles that make the place feel both luxurious and inviting.

Guest favourite
A sunlit corner features large floor-to-ceiling windows offering views of greenery outside. A dark wooden table is accompanied by two cushioned seats, while a cozy seating area with a collection of books and decorative items is situated nearby, contributing to a serene environment.
Flat in Condesa
4.88 out of 5 average rating, 129 reviews

Kaya Kalpa-Organic Designer Apartment in Condesa

After a year-long remodeling project, I’m thrilled to present this personal residence Kaya Kalpa. Every inch of the property has been thoughtfully remodeled. Ideal place for artists, wanderers, all walks of life practitioners to come reset, reflect, and create.  The space is located on Amsterdam street in Condesa, one block from Parque Mexico. You’ll find all nice restaurants, cafes, and stores downstairs. Big supermarket, local Mercado, metro station…all within 5 minutes walking distance.

Guest favourite
The image captures a spacious terrace adorned with various potted plants, leading to a bright bedroom area. Large glass doors open to the patio, allowing natural light to fill the space. A serene landscape and a clear blue sky complement the vibrant greenery.
Loft in Santa María La Ribera
4.96 out of 5 average rating, 340 reviews

Sunny loft with a big terrace in a historic area

New and spacious two stories loft on an award winning renovated building from the 1940´s. Security 24/7 , personal digital code to access the apartment, wifi, fully equipped kitchen, Smart TV with Netflix/Mubi, and a shared laundry room in the building. The loft has one patio in the first floor and a huge terrace full of plants on the second floor next to the bedroom. It is usually very quite but there could be a little noise during the day if another apartment is doing renovations.

Top guest favourite
Loft in Del Valle Centro
4.97 out of 5 average rating, 319 reviews

Remedios Loft with sunsets and a private terrace

✨ Imagina la CDMX con atardeceres a tus pies. Despierta con un aromatico café en un espacio único para escapadas románticas, celebraciones o simplemente desconectar. 📸 Ideal también para sesiones fotográficas. Disfruta de: 🔒 Vigilancia 24 h, estacionamiento y limpieza incluidos. 🚗 A 10 min en Uber de Plaza de Toros, Pepsi Center y Casa Frida Kahlo. 🚇 Cerca del Metro División del Norte y del WTC. Un rincón especial en la CDMX donde cada atardecer se vuelve recuerdo. 🌇

Guest favourite
Flat in Del Carmen
4.89 out of 5 average rating, 18 reviews

Heart of Coyoacán - Balcony & Workspace

Stay in the historic heart of Coyoacán, less than one block from the iconic main plaza. Walk to Frida Kahlo Museum (Casa Azul), Leon Trotsky Museum, Coyoacán Market (3 blocks), Artisan Market (2 blocks), cafés, restaurants, parks, and galleries. This light-filled, architecturally designed apartment features a private balcony and dedicated workspace with fast WiFi — perfect for digital nomads and longer stays in one of Mexico City’s most charming, walkable neighborhoods.

Top guest favourite
Flat in Roma Norte
5 out of 5 average rating, 14 reviews

Roma Norte · Architect-Designed 2BR Apartment

A duplex residence conceived by a recognized architecture studio and furnished by one of Mexico City’s leading design firms. Every material, finish, and object was selected with intention — nothing is accidental. Steps from Roma Norte’s best restaurants, cafés, and galleries. Everything you need is walkable; everything inside is intentional. Full kitchen, premium linens, fast Wi-Fi, and a host committed to one standard: every guest leaves wishing they’d stayed longer.

Top guest favourite
Loft in Ayapango de Gabriel Ramos M.
5 out of 5 average rating, 17 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

Top guest favourite
Flat in Amecameca
4.98 out of 5 average rating, 47 reviews

Wulkan Studio+Breakfast Included

Exclusive studio in the heart of Amecameca de Juárez, just 15 meters from the bus terminal (Volcanes). It features a fully equipped bathroom, a spacious room, a TV and work area, an independent entrance, self check-in, and automated lighting. Enjoy its unique colonial-style façade and a delicious included breakfast. Perfect for relaxing or working comfortably. The only studio with these features in the city!

Top guest favourite
Cabin in Tlalmanalco de Velázquez
5 out of 5 average rating, 11 reviews

A little house near the volcanoes.

Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.

Superhost
Flat in Centro
4.83 out of 5 average rating, 202 reviews

Luxury Loft Historic Center - Next to Bellas Artes

Loft nuevo en edificio moderno frente a la Alameda Central, ideal para dos personas. Cuenta con TV de 50", elevador, cocina equipada con microondas, baño privado y Wi-Fi. A solo 10 minutos del Centro Histórico y cerca de lugares icónicos como Bellas Artes, Torre Latinoamericana y museos. Perfecto para una estancia cómoda, céntrica y con estilo en la Ciudad de México.

Superhost
Flat in Tláhuac
4.83 out of 5 average rating, 53 reviews

Remodeled apartment, kitchen and garden.

10 Blocks from Metro Line 12 Tlahuac Terminal, Independent apartment with kitchen service, full bathroom, small rest room, dining room with refrigerator, microwave and double bed and a parking space. You can use a nice wood and charcoal grill plus gas grill in the large garden, or just spend the afternoon in the courtyard surrounded by vegetation.

Guest favourite
A spacious sleeping area features a large bed with neutral bedding, flanked by two wooden nightstands. A colorful woven rug adds texture to the floor. A full-length mirror is positioned against the wall, reflecting the room's minimalist design, enhanced by natural light.
Home in Roma Norte
4.89 out of 5 average rating, 157 reviews

New Casa Rosa in the heart of Roma neighborhood

A beautiful and newly remodeled pink house in the heart of Roma neighborhood. A home away from home to spend a few days or a long season near historic sites, shops, and local restaurants in a neighborhood with attitude. All the amenities in a house with personality and impeccable architecture and interior design.

Popular amenities for Santa Cruz holiday rentals

  1. Airbnb
  2. Mexico
  3. Santa Cruz