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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Flat in Roma Norte
5 out of 5 average rating, 12 reviews

Magical For 6 Rome, balcony, washing machine, desk

Enjoy a unique experience in the heart of North Rome, steps from Álvaro Obregón, the most iconic and lively avenue in the colony, covered by trees and full of terraces, galleries and local life. ✔ 🌳 Balcony with green views ✔ ☕️ Dozens of signature restaurants, specialty cafes, independent bookstores, designer boutiques and parks full of life, all on foot, without the need for uber. ✔ King Size Bed ✔ Washer dryer ✔ 2nd floor in a building without elevator Fell in love with the best of Mexico!

Top guest favourite
Loft in Roma Norte
5 out of 5 average rating, 14 reviews

Iconic Designer double-height loft

KAAN KIN en un loft de doble altura en el corazón de Roma Norte. Arquitectura excepcional, interiorismo de autor y cada rincón impecable. Completamente equipado: pantalla de 75", sistema de audio Sonos, Wi-Fi de alta velocidad y Aire acondicionado. A pasos de los mejores restaurantes, cafeterías y parques. Comunicación directa y cada detalle resuelto antes de tu llegada. Una residencia con el cuidado de un hotel boutique pensada para quienes buscan una experiencia de primer nivel.

Top guest favourite
A bright living area features large windows allowing natural light to fill the space. Modern furnishings include a comfortable sofa and armchairs, decorated with soft textiles. A dining table and potted plants are visible, adding a touch of greenery to the open atmosphere.
Flat in Condesa
4.94 out of 5 average rating, 102 reviews

Stunning PentHouse w/Terrace by Renowned Architect

Enjoy a luxury experience in this exclusive and spacious 110 m² (1184 sq ft) penthouse located in the heart of La Condesa, steps from Ámsterdam Avenue and the emblematic Mexico Park. ✔ King Size Bed ✔ 1 private terrace of 13 m² (140 sq ft) ✔ 1 Balcony ✔ 24 hour surveillance ✔ Art Deco building from 1946 renovated in 2024 You will find yourself in the favorite neighborhood of locals and travelers, recognized for its tree-lined views and its vibrant cultural and gastronomic offer.

Guest favourite
A spacious living area is depicted, featuring a round glass dining table surrounded by six woven chairs. A wooden bookshelf filled with books is visible in the background, along with a comfortable seating area containing a dark sofa. A large television is mounted on the wall.
Loft in Xochimilco
4.92 out of 5 average rating, 88 reviews

Beautiful suite with a separate entrance

Relax on this unique and quiet getaway in this beautiful space surrounded by nature. Beautiful garden and architecture. Close to attractions in Xochimilco such as the trajineras and the canals and chinampas of Xochimilco and Cuemanco. Traditional village south of the city. Relax in our beautiful place, surrounded by nature. Beautiful green garden and architecture. Close to main attractions like Trajineras, Xochimilco town, canals and chinampas. Traditional town south of the city

Guest favourite
Home in Xochimilco
5 out of 5 average rating, 10 reviews

SmartHouse & Roof Xochimilco Live • Work • Relax

Stay in a stylish, fully equipped smart home designed for comfort and convenience. Enjoy your own private rooftop garden, perfect for morning coffee, sunset drinks, or relaxing after the match. Your stay includes: ✓ Fully equipped kitchen ✓ Washer ✓ Fast WiFi ✓ Private parking ✓ Smart home amenities ✓ Great access to transportation and main roads Conveniently located near Estadio Azteca, Coyoacán, and Xochimilco, with easy access to public transit, restaurants and cafés.

Guest favourite
A spacious living area features a high ceiling and exposed brick walls, illuminated by soft lighting. A large mirror hangs above a simple coffee table, surrounded by a cozy sofa and two armchairs. Indoor plants add a touch of nature to the inviting space.
Casa particular in Álvaro Obregón
4.94 out of 5 average rating, 31 reviews

My San Angel Refuge

Mi Refugio San Angel, is a spacious and modern space, to feel out of the city, being centrally in it. It has a Temazcal (under reservation), hydromassage tub, terraces, garden with hammocks, lounge chair, outdoor dining area, bonfire area, indoor fireplace. 2 rooms with full bathroom, queen size sofa bed; open, spacious and fully equipped kitchen. Private parking. The main room can be opened to a view towards the double height of its large room.

Top guest favourite
Loft in Ayapango de Gabriel Ramos M.
5 out of 5 average rating, 19 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

Guest favourite
Cabin in Tlalmanalco de Velázquez
5 out of 5 average rating, 12 reviews

A little house near the volcanoes.

Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.

Top guest favourite
A charming outdoor patio is surrounded by vibrant greenery and a blue-walled house. A round glass table is complemented by six white metal chairs, creating an inviting space for dining or gathering. Potted plants and flowers add color to the serene environment.
Home in Coyoacán
4.97 out of 5 average rating, 107 reviews

Casa Omac | Colonial house with two patios

Typical colonial house, located in the most picturesque and emblematic street of Coyoacán. The style is reminiscent of Frida Kahlo's Blue House, which is a few minutes' walk away. Organized around a large internal patio, the house has 5 double rooms and can host up to 10 people, making it ideal for groups and families.

Top guest favourite
The living room features a warm color palette with wooden accents. A central coffee table is surrounded by two cozy armchairs and a sofa. Shelves filled with decorative items and books create a welcoming space, while natural light fills the room through the open doors.
Home in Coyoacán
4.96 out of 5 average rating, 142 reviews

Fantastic library house Octavio Paz @Coyoacan

In downtown Coyoacán, a better location is impossible. Quiet, captivating, spacious, surrounded by greenery. This beautiful and quiet house was where the Vuelta Magazine of the Nobel Prize for Literature Octavio Paz was in its last years. An old house that is over a century old.

Guest favourite
An outdoor terrace is presented with a wooden pergola, casting dynamic shadows across a spacious wooden dining table surrounded by benches. A kitchen area is visible with a modern design, and various potted plants are arranged along the perimeter, enhancing the natural ambiance.
Loft in Coyoacán
4.94 out of 5 average rating, 641 reviews

ECO-ROOF with terrace in the heart of Coyoacán

Nice and cozy room with a private balcony in the heart of Coyoacán, one of the most picturesque and traditional neighborhoods in Mexico City. Located a 5-minute walk from downtown Coyoacan, traditional restaurants, cafes, craft bazaars, and museums.

Top guest favourite
The exterior of a two-story house is surrounded by lush greenery and vibrant planters. A small terrace features a white umbrella, where a person is seated, enjoying the garden view. A paved pathway leads to the entrance, enhancing the welcoming atmosphere.
Loft in Del Carmen
4.95 out of 5 average rating, 255 reviews

Loft Coyoacan Viveros (Bow)

A super special and very cozy place in the heart of Coyoacán! right next to Coyoacán nurseries, on Melchor Ocampo street Ideal for a couple with or without children who want to enjoy a pleasant stay or a good walk through the wonders of Coyoacán :)

Popular amenities for Santa Cruz holiday rentals

  1. Airbnb
  2. Mexico
  3. Santa Cruz