
Holiday rentals in Santa Cruz
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Top-rated holiday rentals in Santa Cruz
Guests agree: these stays are highly rated for location, cleanliness and more.

Magical For 6 Rome, balcony, washing machine, desk
Enjoy a unique experience in the heart of North Rome, steps from Álvaro Obregón, the most iconic and lively avenue in the colony, covered by trees and full of terraces, galleries and local life. ✔ 🌳 Balcony with green views ✔ ☕️ Dozens of signature restaurants, specialty cafes, independent bookstores, designer boutiques and parks full of life, all on foot, without the need for uber. ✔ King Size Bed ✔ Washer dryer ✔ 2nd floor in a building without elevator Fell in love with the best of Mexico!
4.95 out of 5 average rating, 19 reviews
Family Home in a Private, Quiet, and Safe Area.
Your home away from home in the State of Mexico! 🏡✨ Enjoy a peaceful, comfortable, and safe stay in this spacious house that accommodates 5 people. It features: 🛏️ 3 bedrooms, each with a double bed. 🛋️ 2 hallways, each with a sofa bed. 🚽 2.5 bathrooms (2 full bathrooms and one half-bath). 🍳 Fully equipped kitchen, Smart TV, and Wi-Fi. 🚗 Private, secure parking. Pets welcome (please check the rules regarding the 500 MXN surcharge). Total privacy for your trip! Pura vida! 🇨🇷🇲🇽
4.98 out of 5 average rating, 63 reviews
José Clemente Orozco House Coyoacán
Located in Coyoacán, typical Mexican neighborhood surrounded by markets, museums and historical buildings, a few blocks from Museu Frida Khalo, this house was the first studio for the painter and muralist José Clemente Orozco, who designed and build it between 1921 and 1923. All the bedrooms have their own bathroom and the main suite has a king-size bed, Smart TV and a terrace. It has a big and beautiful garden and a work space with its own terrace too. The garden is shared by 2 houses.
4.95 out of 5 average rating, 393 reviews
S12 Colonial Studio in Historic Center of CDMX
A large, newly renovated 17th century house with vintage touches and all the modern amenities for you to enjoy a pleasant stay. We are located in the heart of Mexico City's Historic Center, just 2 blocks from the Cathedral and the Zócalo. Each room has a kitchenette, induction grill, mini fridge, oven, coffee maker, blender and basic utensils to cook whatever you like, as well as towels and a dryer. If an iron and ironing board are required, please request them.
4.85 out of 5 average rating, 203 reviews
Safety and Comfort in Edo.MEX
An apartment with great comfort, space, and security. It has a closed circuit, automatic main entrance door, alarm against theft, carbon monoxide and fire, excellent internet quality, and Smart TV. It has a lighting system with 3 shades: White, semi-warm and warm light, suitable for study and rest. The central stairs have handrails, non-slip, and sensor lighting. Fully-equipped kitchen and bathroom. Practical location with amenities available.
4.98 out of 5 average rating, 256 reviews
Casa Mavi's loft in Coyoacán
Welcome to Coyoacán! Great 120 m2 loft located just a 5-minute walk from downtown Coyoacán. Experience this quiet and bright open space, ideal for resting or working and decorated with objects full of stories. The loft is located on the third floor of Casa Mavi, an old factory that was remodeled to create a place full of charm that makes it unique. It has shared terraces. With option for a third guest. 200 megabyte Wi-Fi.
4.87 out of 5 average rating, 231 reviews
Beautiful apartment with garden and volcano view
Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.
5.0 out of 5 average rating, 22 reviews
A little house near the volcanoes.
Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.
5.0 out of 5 average rating, 14 reviews
Casita Suite | WiFi, bath, kitchen | in Coyoacan
Welcome to La Casita, a 450 sq (42 m²) suite that is part of the seven suites in the iconic El Guajolote de Coyoacan. 📍 Just steps away from the Frida Kahlo House and Coyoacán Plaza. 🔐 Private spaces: kitchen, private bathroom, and a cozy sitting area. 🛏️ Queen Size bed. ✍️ Ideal for couples, writers, or nomads. 🌿 Enjoy the tranquility and authenticity of the neighborhood.
4.88 out of 5 average rating, 444 reviews
Equipped loft in CDMX within equestrian centre
Furnished apartment inside a beautiful equestrian center. Live with beautiful horses, practice horseback riding, and visit our private forest. Enjoy an extraordinary breakfast and lunch at our iconic restaurant. Note: additional activities and consumption not included in the price of the accommodation.
4.89 out of 5 average rating, 255 reviews
Garden and beautiful house for events and stays
Camino Real Event Garden Disconnect from your concerns in this spacious and serene space. Ideal for all kinds of events, children's parties, meetings, weddings, corporate events, workshops, yoga courses or any other outdoor exercise or activity 🍃🌿🌤️
5.0 out of 5 average rating, 52 reviews
Colonial house with garden in the center of Coyoacán
Luxury colonial house, 350 meters from the center of Coyoacan. The house has a garden and terrace. We strive to make your stay perfect. If your stay is long, we have cleaning service included.
4.96 out of 5 average rating, 168 reviewsPopular amenities for Santa Cruz holiday rentals
Other great holiday rentals in Santa Cruz

Artisanal Loft in Coyoacán
4.96 out of 5 average rating, 49 reviews
Apartment with a bathtub in the center and panoramic view
4.91 out of 5 average rating, 69 reviews
Comfortable apartment near GNP stadium and racetrack
5.0 out of 5 average rating, 54 reviews
Designer's Haven in Roma with Private Rooftop
5.0 out of 5 average rating, 15 reviews
A little house
5.0 out of 5 average rating, 82 reviews
Sanctuary Loft Anzures | Romantic Spa Tub | 2 Gsts
5.0 out of 5 average rating, 14 reviews
The Green House
5.0 out of 5 average rating, 42 reviews
La Ciruelita - Country house with fireplace
4.92 out of 5 average rating, 52 reviewsDestinations to explore
- The Angel of Independence
- Foro Sol
- Val'Quirico
- Reforma 222
- Palacio de los Deportes
- Aztec Stadium
- Autódromo Hermanos Rodríguez
- Basilica of Our Lady of Guadalupe
- World Trade Center Mexico City
- Auditorio Nacional
- Six Flags Mexico
- Monument To the Revolution
- Pyramids Of Teotihuacán
- Pepsi Center Wtc
- Las Estacas Parque Natural
- Alameda Central
- Palacio de Bellas Artes
- Los Dinamos
- Izta-Popo Zoquiapan National Park
- El Rollo Parque Acuático
- Citibanamex Center
- Jardines de México
- Constitution Square
- Bosque Geométrico





