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Holiday rentals in Santiago

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santiago

Guests agree: these stays are highly rated for location, cleanliness and more.

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A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Flat in Los Canelos
4.73 out of 5 average rating, 56 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Guest favourite
Flat in Santiago
4.92 out of 5 average rating, 13 reviews

Comfortable and safe apartment in downtown Santiago

Family-friendly apartment in the centre of Santiago — comfortable, safe and fully equipped Enjoy a prime location right in the heart of Santiago de Veraguas, just a short walk from the cathedral, the municipal park and the main avenue. Everything you need is within walking distance: supermarkets, pharmacies, banks, shops, restaurants and public transport. Ideal for families, professionals, business travellers, or people visiting the city for official purposes or events.

Home in Santiago
5 out of 5 average rating, 3 reviews

Yary's Little House

Mi alojamiento es especial por su Comodidad y Ubicación. Este alojamiento es perfecto para disfrutar en viajes de trabajo, en grupo o relajarte en familia. Ubicado estratégicamente en la entrada de la ciudad de Santiago, te permite estar cerca de todo: supermercados, restaurantes, centros comerciales y más. 🏡 El espacio Disfruta de un ambiente cómodo, moderno y acogedor que hará de tu estadía una experiencia inolvidable. se agradece no fumar dentro de la propiedad.

Home in Santiago
4.8 out of 5 average rating, 10 reviews

Casa Valle de Barbarena

Excelente ubicación cerca del centro a tan solo 2 kilómetros un lugar tranquilo. Cerca del mall Casa de dos cuartos y dos camas Doble un sofá cama Espacio de Lavandería o depósito de almacenamiento Nice location near the city 2 km Away from the center of Santiago close to the mall It has 2 rooms each with a doble bed and a sofa bed in the living room Laundry room with nice space to bring in your bike or any thing that you will like to store inside the house.

Guest favourite
Home in Canto del Llano
4.91 out of 5 average rating, 44 reviews

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Flat in Santiago
5 out of 5 average rating, 5 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

A welcoming living area features a comfortable leather sofa and a small dining table with two chairs. Natural light fills the space from sliding glass doors that open to a balcony, enhancing the connection with the outdoors. A kitchenette and a red refrigerator are visible in the corner.
Flat in Santiago
4.68 out of 5 average rating, 19 reviews

d'rosas apartments 5PA

Enjoy the simplicity of this quiet and central accommodation. Discover comfort in our cozy accommodation in the heart of Santiago, Veraguas. Just a 5-minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring the local culture and resting after a day of adventures. We look forward to seeing you!

A modern cabin is nestled among trees, featuring a covered porch with wooden railings and seating. The facade includes stacked stone accents, and large windows offer views of the surrounding nature. The pathway leading to the cabin is lined with grass and foliage.
Place to stay in Las Minas
4.6 out of 5 average rating, 5 reviews

Exclusive cabin with Jacuzzi and unforgettable landscape

Escape to the tranquility of the Montuoso in Chepo de Las Minas and enjoy a unique experience in our private cabin. Perfect for a romantic getaway or a family vacation, this accommodation offers privacy, comfort and a breathtaking view of the mountains. Designed to give unforgettable moments, our cabin combines rustic charm with modern details.

Superhost
The exterior of a modern single-story house is displayed, featuring a covered driveway and a well-maintained lawn. Large windows provide natural light, while a pathway leads to the entrance. The surrounding area is open and well-kept, contributing to a welcoming appearance.
Home in Santiago
4.78 out of 5 average rating, 114 reviews

3BD, 2BTHS, furnished house

House with 3 bedrooms, 2 bathrooms, central, furnished, security booth, kitchen, automatic washing machine, A/A, Wi-Fi, cable TV, new construction in a nice residential area.

Guest favourite
Home in Santiago
5 out of 5 average rating, 10 reviews

A few metres from Mall, Supermarkets, Hospital, etc.

Cozy, spacious, wifi, meters from Pricemart, pharmacies, restaurants, 40 minutes from Playa Torio, for families and groups of friends

Superhost
A single-story house features an arched entry with decorative windows. The front porch is equipped with seating, surrounded by greenery. A paved driveway leads to the home, providing access for vehicles, while the roof offers ample shade.
Home in Santiago
4.74 out of 5 average rating, 39 reviews

Casa Nuevo San Juan

Easy access from the Panamericana. It is a central area with supermarket, pharmacy, restaurant, hospital.

Top guest favourite
Flat in Santiago
5 out of 5 average rating, 34 reviews

A spectacular apartment in Santiago

Your family will be close to everything when you stay at this centrally-located place.

Popular amenities for Santiago holiday rentals

  1. Airbnb
  2. Panama
  3. Veraguas Province
  4. Santiago