Places to stay near Buffalo Museum of Science

Book unique holiday rentals, homes and more on Airbnb

Top-rated holiday rentals near Buffalo Museum of Science

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
The exterior of a two-story house features a welcoming entryway with a front porch and a staircase leading up to it. Lush greenery surrounds the property, and colorful flowers are planted along the stairs. A manicured lawn is presented in a neat landscape design.
Flat in Buffalo
4.88 out of 5 average rating, 120 reviews

D&C Airbnb adds home-like comfort to your travels.

D&C Airbnb adds home-like comfort to your travel experience. Clean, cozy, quiet and secured 2nd floor apt. Centrally located on Main Street near main highway and public transportation. Your stay includes living room with flat screen tv and surround system and dining room seats four.Living and dining room areas have original woodwork. All standard kitchen amenities including microwave and coffee maker. Bathroom has full size tub and shower. Two bedrooms with queen size beds & ample closet space.

Superhost
A monochromatic living area is showcased, featuring a patterned black-and-white sofa paired with minimalist stools and a sleek coffee table. Light fixtures hang from the ceiling, and a glimpse of the kitchen is visible in the background, complemented by clean lines and artistic wall designs.
Flat in Buffalo
4.84 out of 5 average rating, 269 reviews

The 2D Spot!

Buffalo's 1st official 2D Airbnb; all hand painted by local Artists. With ideal proximity to DT Buffalo, Elmwood Village & Allentown, you'll find yourself at the heart of the city's culture. Also just a 25 minute drive to the iconic Niagara Falls. Whether you're a first time visitor to Buffalo or a local seeking a unique escape, The2DSpot invites you to step inside the pages of a comic book. Immerse yourself in a world of imagination & book your stay today! Experience Buffalo like never before.

Guest favourite
The living area features a comfortable gray couch with decorative cushions, a wooden side table with a lamp, and an area rug. An artistic cityscape is displayed on the wall, while a dining area is visible through the archway with a table and chairs.
Flat in Buffalo
4.85 out of 5 average rating, 312 reviews

Historic Apartment Steps Away from Allentown Area

This spacious 1-bedroom apartment is conveniently located in the heart of Allentown. It is fully furnished and includes everything you will need to have a comfortable, enjoyable stay. This is 1 of 3 airbnbs located in a historic multi-unit home. This space is the perfect getaway for couples, business stays, and traveling nurses. It is situated in a quiet residential neighborhood, steps away from Allen St. The front door opens to a small park that was designed by Frederick Law Olmsted in 1887.

Top guest favourite
The living room features a cozy arrangement of light-colored sofas with colorful accent pillows. A dark coffee table is centered in the space, complemented by a patterned rug beneath. A brick fireplace serves as a focal point, with built-in shelves displaying books and decor, while natural light filters through the windows.
Flat in Buffalo
4.95 out of 5 average rating, 171 reviews

Elegant Elmwood Village Hideaway-New Outdoor Patio

New in July 2025 - Outdoor Patio! Bright, spacious 3 bedroom apartment at the gateway to the Elmwood Village; over 300 local shops, coffeehouses, restaurants, bars, and art galleries. The house is set back from street with off street parking. Private grand entrance to a large living/dining room, gas fireplace, hardwood flooring throughout. Walk to: Albright Knox Art Gallery, Burchfield Penney Art Center, Buffalo State, Delaware Park, Hotel Henry and more. Niagara Falls only 20 minutes away.

Guest favourite
A cozy back porch is illuminated by string lights, casting a warm glow over the area. A hot tub is positioned near the railing, while a wooden bench and a small table provide seating options. The house features large windows, revealing a glimpse of the inviting indoor space.
Home in Buffalo
4.96 out of 5 average rating, 152 reviews

Modern Full Home: Hot Tub, Updated Kitchen & Bath

**This is an entire home listing. There is no one else that will be at the house.** Enjoy a stylish experience at this centrally-located single family home. With an updated kitchen, a/c downstairs master BR, guest BR and attic (may-sept). Ultra modern bathroom has a walk-in shower with 2 rain shower heads, 1 extra deep bathtub, heated floor, marble counter tops & bidet Outside you will have a large back porch which includes a hot tub & string lights to enjoy during the cool Buffalo evening.

Top guest favourite
A modern kitchen features sleek white cabinetry and a dark countertop. A stainless steel refrigerator and gas stove are visible, alongside a microwave. Natural light enters through nearby windows, illuminating the space. A patterned rug lies on the floor, adding a touch of comfort.
Guest house in Buffalo
4.99 out of 5 average rating, 242 reviews

Hidden Parkside Carriage House near everything.

This beautifully redone 1915 Carriage house that is just 2 blocks from Delaware park , The zoo and the Darwin Martin house. Fully updated with plenty of room to cook and relax. 55in Smart tv and all brand new furniture. If you do not want to drive it is a 2 block walk to the train that can take you right downtown, Canalside or the Keybank Center (Sabres Arena) . Located right off the 33 so minutes to the airport , downtown and about 20 minutes to Niagara Falls and 20 to Highmark Stadium.

Guest favourite
Castle in Buffalo
4.89 out of 5 average rating, 118 reviews

Luxury Rooftop Loft Gym Pickleball+ Basketball EV+

Welcome to our enchanting loft, where romance meets family-friendly charm in a historic setting. This unique space has been the backdrop for 3 movies. Tesla EV charger. Enjoy light therapy experienced through stained glass, a gym with Peloton and rowing machines. Challenge friends on the indoor basketball court. Enjoy seasonal rooftop with a grill and lounge chairs for delightful gatherings. Enjoy tree-lined stroll to vibrant Elmwood Village & Allentown, with dining and shopping options.

Top guest favourite
A bright and airy open-concept living space features a large dining table surrounded by blue chairs, positioned next to expansive windows that offer views of the lake and Buffalo skyline. A wall-mounted TV is visible, enhancing the modern, clean design.
Home in Fort Erie
4.96 out of 5 average rating, 162 reviews

Bright, Beautiful Lakefront @ Historical Fort Erie

Come home to relax in our beautifully decorated lakefront escape in the sweet town of Fort Erie. Our home is a large open concept with a smart TV, free Wi-Fi, fully equipped kitchen, 3 clean & comfortable bedrooms, 2.5 bathrooms and everything else you need for your perfect vacation. You'll be located across the street from the lake and a 2 minute walk to the old fort. Enjoy a stroll (or bike) along the lakeside path into old Fort Erie where you will find shops and fine restaurants or pubs.

Top guest favourite
The exterior view of the cottage highlights a well-maintained lawn with a lighthouse feature nearby. The blue sky complements the cottage's design, featuring a metal roof and large windows. Surrounding trees provide a natural backdrop, enhancing the serene environment.
Cottage in Fort Erie
4.87 out of 5 average rating, 294 reviews

Niagara Riverview Entire Cottage, EV Charger

The Light House Cottage offers a peaceful retreat with a stunning view of the Niagara River. Equipped with a Level 2 EV Charger,. Just 15 minutes drive from the breathtaking Falls and only 5 minutes drive from the nearest business district. It provides both scenic beauty and convenient access to everything you need. Enjoy a charming walking trail right outside the house along the river, creating the perfect escape from city life to spend precious time with loved ones in a tranquil setting.

Superhost
A cozy living room is featured, showcasing a grey sectional sofa adorned with colorful pillows. A sleek television stands on a dark media unit, accompanied by a modern floor lamp. Light filters through a nearby window, enhancing the warm tones of the area rug.
Flat in Buffalo
4.86 out of 5 average rating, 516 reviews

Clean, Spacious, Convenient, Comfortable, Historic

- Impeccably decorated - Recently updated - 1st-floor apartment of a - Historic home - Heart of Buffalo - A few minutes to all of Buffalo's favorite spots - Budget conscious Midtown is a distinctly urban and multi-cultural neighborhood that is beginning a renaissance. If you are intimidated by the urban setting, you might be out of your comfort zone. You will see a few vacant houses and might hear a distant ambulance (nearby hospital) in this safe and quiet neighborhood.

Guest favourite
The living area features a navy blue carpet with a sofa and coffee table situated in front. A fully equipped kitchen is seen in the background, equipped with dark wooden cabinets and modern appliances. Light fixtures enhance the well-lit atmosphere.
Flat in Buffalo
4.94 out of 5 average rating, 374 reviews

Cozy Apartment in LarkinVille (Unit 2)

If this listing is not available please check out my other listings This 1st floor apartment features an open concept kitchen & living room with stove, refrigerator & microwave. A queen sleeper sofa & 54" smart TV are in the living room. The bedroom has a queen bed & dresser. The space features a In unit washer & dryer soaker jacuzzi tub and A/C mini split to help cool down the space. This is a mix use property with periment tenants as well as other guest. Noise is typically low

Guest favourite
A modern dining area features a round wooden table surrounded by four white chairs. A stylish light fixture hangs above, complemented by green accent walls. The open layout connects to a well-equipped kitchen with white cabinetry and bar seating, illuminated by natural light from surrounding windows.
Flat in Buffalo
4.87 out of 5 average rating, 244 reviews

Five Points Apartment- Upper Unit

Updated Upper Unit Apartment. Great City Location! Walking Distance to Five Points, and Lower West Side Restaurants and Shops. Off Street Parking (when available). In Unit Laundry. WiFi. Pets Allowed ($50 pet fee). Queen Bed and Fold Down Futon. Blocks from D’Youville University and minutes from Buffalo State University! Close to Kleinhans Music Hall, Elmwood Village and Allentown! 10 Min Drive To KeyBank Center - 20 Min Drive To Highmark Stadium - 20 Min Drive To Niagara Falls

Popular amenities for holiday rentals near Buffalo Museum of Science