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Holiday rentals in Isthmus of Panama

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Top-rated holiday rentals in Isthmus of Panama

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira
4.97 out of 5 average rating, 113 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Guest favourite
A traditional bohio with a thatched roof is set amidst lush greenery. A pathway leads to a serene pool, flanked by vibrant tropical plants and flowers. The surrounding landscape features distant mountains, softly illuminated by the warm light of dusk.
Guest house in El Valle de Antón
4.93 out of 5 average rating, 103 reviews

The Retreat in El Valle - Garden House

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Top guest favourite
An open living space features a wooden dining table surrounded by six wicker chairs. Two hanging hammocks are displayed on the covered terrace, offering views of the lush hills. Large glass doors reflect the greenery, blending indoor and outdoor spaces harmoniously.
Cabin in Torio
4.97 out of 5 average rating, 186 reviews

Cozy open space, unique jungle views, river access

An open-style jungle home with mesmerizing treetop and mountain views. Located 10 minute walk to the beach, with a trail that leads to the River. The house is not childproof! It has three individual bedrooms, each with its own key. The price is based on the number of guests. The entire house is always yours. The house offers fiber optic WiFi and two dedicated workspaces. The property is surrounded by large trees, naturally keep the house cool and provide shelter for birds and wildlife.

Top guest favourite
Cabin in Penonome
4.98 out of 5 average rating, 133 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Top guest favourite
A welcoming outdoor seating area is featured, adorned with two wooden chairs facing a small, simple table. Lush greenery surrounds the space, with a wooden lattice design on one side and warm lighting accentuating the inviting atmosphere.
Bungalow in Puerto Viejo de Talamanca
4.91 out of 5 average rating, 117 reviews

2bdr house w. private plunge pool in jungle garden

COMFORTABLE HOME IN RAINFOREST GARDEN Fully equipped 2-bedroom house in wonderful tropical setting. Enjoy nature & spot wildlife at Casa Lirio. Walking distance from gorgeous beaches (1.5km), 5 min drive to lively Puerto Viejo & 20 min to Cahuita National Park. Fiber optic wifi, airco, fully fitted kitchen with all basics & 18L bottled water. AC. Breakfast US$15 pp per day, paid laundry service. The house is on the outskirts of the property, so there is some street noise.

Superhost
A tranquil dipping pool is framed by lush greenery, featuring white loungers and a large umbrella for shade. The pool area exudes a serene vibe with vibrant bougainvillea in the background, enhancing the inviting outdoor space.
Home in Taboga Island
4.94 out of 5 average rating, 216 reviews

Casa Rosie - Dream Home on Tabogá Island

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Guest favourite
Home in Altos del Maria
4.75 out of 5 average rating, 150 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Guest favourite
A small pool sits within a wooden deck area, surrounded by lush greenery. Steps lead from the deck to the pool, where a gentle waterfall feature adds a soothing element. Lounge chairs are positioned nearby for relaxation in a tranquil setting.
Guest house in Panamá Oeste
4.84 out of 5 average rating, 143 reviews

Mountain cabin with private pool

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Possibility of having 1 double bed and 2 single beds or 4 single beds. - Discount for two nights or more.

Guest favourite
Villa in El Copé
4.92 out of 5 average rating, 190 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Guest favourite
A spacious living area features light wood flooring and a modern open kitchen. Two light-colored sofas surround a marble coffee table, while a dining area with a stylish table sits nearby. A spiral staircase leads to the upper level, and decorative artwork adorns the walls.
Loft in Panamá
4.93 out of 5 average rating, 120 reviews

Loft 3b Old Town Best! It's 150 m2 (492 feet)

Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.

Guest favourite
The two-story house is positioned just steps from the water's edge, surrounded by lush greenery and palm trees. A spacious terrace extends from the upper floor, providing a view of the serene landscape. The natural stone shoreline complements the tranquil setting.
Flat in Colón
4.94 out of 5 average rating, 108 reviews

KasaKai garden floor - amazing views over the sea

Caribbean downstairs apartment with amazing sea view. Surrounded by wildlife. This property has a private access to the Caribbean Sea. The house is situated over a 2 miles long reef. Amazing snorkeling, there are many naturals pools into the reef where you can snorkel. Ideal for kids! There is a jungle behind the house which makes that you will hear the monkey from the house.

Top guest favourite
A hot tub with bubbling water overlooks a panoramic view of the mountains and valleys. The expansive sky features soft clouds, creating a serene atmosphere. A railing surrounds the deck, providing safety while enjoying the stunning landscape.
Cabin in Altos del Maria
4.93 out of 5 average rating, 57 reviews

Blue Sky Lodge; the best view in Altos del María

This luxury mountain cabin offers a modern design, quality finishes, and 180° panoramic views of mountains and sea. It is located in a secure gated community, surrounded by a green garden, with large glass windows that favor connection with nature. The climate is pleasant, with temperatures between 23°C and 28°C. .

Popular amenities for Isthmus of Panama holiday rentals