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Holiday rentals in Isthmus of Panama

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Top-rated holiday rentals in Isthmus of Panama

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira
4.97 out of 5 average rating, 113 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Top guest favourite
An open living space features a wooden dining table surrounded by six wicker chairs. Two hanging hammocks are displayed on the covered terrace, offering views of the lush hills. Large glass doors reflect the greenery, blending indoor and outdoor spaces harmoniously.
Cabin in Torio
4.97 out of 5 average rating, 186 reviews

Cozy open space, unique jungle views, river access

An open-style jungle home with mesmerizing treetop and mountain views. Located 10 minute walk to the beach, with a trail that leads to the River. The house is not childproof! It has three individual bedrooms, each with its own key. The price is based on the number of guests. The entire house is always yours. The house offers fiber optic WiFi and two dedicated workspaces. The property is surrounded by large trees, naturally keep the house cool and provide shelter for birds and wildlife.

Guest favourite
Cabin in Altos del Maria
4.89 out of 5 average rating, 27 reviews

Deimos – Modern Mountain Cabin with Heated Pool

Deimos is a one-bedroom cabin featuring a fully equipped kitchen, a modern bathroom, and a living room that opens onto a private terrace with a jacuzzi. The property consists of a total of three houses, and Deimos is located at the highest point, slightly farther from the others, offering added privacy. The tiny home comes fully equipped with everything needed for a weekend getaway or a longer stay, making it the perfect place to relax and enjoy the amenities of Altos del María.

Top guest favourite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonome
4.98 out of 5 average rating, 133 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Top guest favourite
A cozy living area is created with wooden accents and tropical plants. A wooden bench and a chair are positioned against a decorative wood panel, with a small shelf displaying art and plants. Natural light brightens the space, enhancing its inviting atmosphere.
Bungalow in Puerto Viejo de Talamanca
4.91 out of 5 average rating, 117 reviews

2bdr house w. private plunge pool in jungle garden

COMFORTABLE HOME IN RAINFOREST GARDEN Fully equipped 2-bedroom house in wonderful tropical setting. Enjoy nature & spot wildlife at Casa Lirio. Walking distance from gorgeous beaches (1.5km), 5 min drive to lively Puerto Viejo & 20 min to Cahuita National Park. Fiber optic wifi, airco, fully fitted kitchen with all basics & 18L bottled water. AC. Breakfast US$15 pp per day, paid laundry service. The house is on the outskirts of the property, so there is some street noise.

Top guest favourite
A balcony is visible with colorful tiled tables and black wrought iron chairs. Lush potted greenery adds a natural touch, while surrounding buildings with terracotta roofs can be seen in the background. The scene is illuminated by daylight, enhancing the vibrant colors.
Loft in Panama
4.99 out of 5 average rating, 174 reviews

Patty’s Casco 2BR Loft | Balcony & Personal Touch

“Feel at home in Casco Viejo—personally welcomed by your hosts, Patty & Rudy.” Stay in the Heart of Casco Viejo with Patty’s Casitas! Prime Casco Viejo Location | Quiet, Convenient & Charming Stay steps from restaurants, cafés, bars, and plazas—right by the El Rey boutique supermarket and the waterfront promenade. This peaceful spot is rare in Casco, tucked away from rooftop noise and perfectly located at the entrance of the neighborhood for easy in & out access!

Superhost
A tranquil dipping pool is framed by lush greenery, featuring white loungers and a large umbrella for shade. The pool area exudes a serene vibe with vibrant bougainvillea in the background, enhancing the inviting outdoor space.
Home in Taboga Island
4.94 out of 5 average rating, 217 reviews

Casa Rosie - Dream Home on Tabogá Island

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Top guest favourite
Home in Bastimentos Island
5 out of 5 average rating, 23 reviews

Eco-Luxury Overwater Villa • SUPs • Kayaks • A/C

Escape to paradise in this eco-luxury overwater villa on Isla Bastimentos, minutes from Bocas Town. This 2-bedroom, 2-bath retreat features direct ocean access and a private dock. Enjoy complimentary kayaks and standup paddleboards (SUPs), plus Wi-Fi and A/C. The living room’s accordion glass doors open to the deck for seamless indoor-outdoor living. Swim, snorkel, paddle, or relax as the sun sets over the Caribbean. Your ultimate island getaway awaits!

Guest favourite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 191 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Guest favourite
A private deck features two modern chairs with a small table between them, positioned on a textured area rug. A custom-built jacuzzi is visible in the background, surrounded by a wooden railing. Natural light floods the indoor living area through expansive glass doors.
Cabin in Boquete
5 out of 5 average rating, 8 reviews

New World Casita @ Finca Panda

Mundo Novo is one of our new, one-room casitas and has one of the most incredible views on the property. Perfect for couples, singles or family with a small child, Geisha sleeps 2 people comfortably in one king bed (maximum 3 guests when using sofa). Geisha was designed with every amenity needed to have a perfect and relaxing stay. Custom-built jacuzzi, fire-pit, kitchen, incredible shower, high-speed WiFi and more

Guest favourite
The villa is nestled amongst lush greenery, with vibrant trees bordering a sandy beach. The crystal-clear water gently laps at the shore, leading to a spacious, modern home set back in the landscape, ensuring a private and serene environment.
Home in Saboga
4.95 out of 5 average rating, 41 reviews

Spectacular ocean view, private beach access, pool

Discover Saboga Island, home of the famous Survivor TV Show, in this magic property: Villa 'Corral Cove' is located in a pristine environment with a fantastic view of the beach. This 'architect' home has been built recently and has been decorated with style and comfort in mind. You will love the serenity of this unique place, perfect for resting and having unforgettable family moments.

Guest favourite
The two-story house is positioned along the shoreline, featuring a spacious terrace and a wooden deck. Lush greenery surrounds the property, while several palm plants are placed near the entrance. Steps lead from the house to the water, creating easy access to the sea.
Flat in Colón
4.94 out of 5 average rating, 108 reviews

KasaKai garden floor - amazing views over the sea

Caribbean downstairs apartment with amazing sea view. Surrounded by wildlife. This property has a private access to the Caribbean Sea. The house is situated over a 2 miles long reef. Amazing snorkeling, there are many naturals pools into the reef where you can snorkel. Ideal for kids! There is a jungle behind the house which makes that you will hear the monkey from the house.

Popular amenities for Isthmus of Panama holiday rentals