
House holiday rentals in Los Santos Province
Find and book unique houses on Airbnb
Top-rated house rentals in Los Santos Province
Guests agree: these houses are highly rated for location, cleanliness and more.

Breathtaking Views: Sleeps 13, Walk to Beach!
There’s something special about this place. Every guest says the same thing—they never want to leave. Imagine waking up to the sound of waves and birdsong, sipping coffee on the balcony with sweeping ocean views. This peaceful retreat in Venao is at the quiet end of the beach, away from the party scene—but close enough to dive into the action when you want. Swim, surf, and dine nearby, then come home to the tranquility of your private lodge, where the only nightlife is the glow of the stars.

Nearly Oceanfront: Blue 3 Bedroom Spacious Villa
Villa-33, your exquisite retreat nestled within Blue Playa Venao. Discover a tropical paradise of stunning beaches. Embark on endless adventures just a short walk away. This beautiful Villa offers 3 bedrooms and 3 baths. Two of the bedrooms feature queen beds, while the third bedroom has 2 twin beds, ensuring a restful night's sleep for everyone. The living area, kitchen, and terrace are thoughtfully equipped with everything you need to make yourself at home during your fun family getaway.

3 min to Pedasi, 5 min to the Beach, Private Pool!
Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Casa - Domaine De La Rose
Welcome to paradise ! Beautiful home with private pool and a large yard - amazing for entertaining family/ friends 1 master bedroom with full bath with jacuzzi, french doors to terrace 1 queen bed with full bath -1 double/ single bunk bed with full bath Open dining , kitchen and living room Full access to Andromeda Beach Club Full restaurant & bar - always something to do! Massive infinity pool with steps to the Pacific Ocean !! Beach is very beautiful and private and miles to explorer

Beachfront Gem w/ Ocean Views & Prime Surf Access
Welcome to your slice of beachfront paradise! Our home sits right on Cambutal's beautiful shoreline. Gorgeous ocean views greet you from every window, while the gentle rhythm of waves creates the perfect soundtrack for your stay. We've equipped the house with Starlink WiFi and a large dining table that doubles as an ideal workspace, making this a perfect retreat for both vacationers and remote workers. The house feels like a real home – comfortable, clean, and ready for your beach memories.

NinaHouse, spacious and cool house in Chitré.
House just for you, now with a water tank! Up to 7 people, spacious and in one of the best areas of Chitré, quiet and family-friendly, access to the pool in the social area, parks and courts, close to everything: supermarkets, casino, bus; come to Chitre and enjoy typical meals, crafts; plan your walks and visit the best beaches: Pedasi, Venao, Isla Iguana, you can work from NinaHouse with fast internet. We now have air conditioning in the living room for your comfort.

Pedasí, Los Destiladeros Beach / Casa Serena
❤ Welcome to Casa Serena, escape to our stunning 3-bedroom ocean view house, perfectly located in Playa Los Destiladeros, an area of beautiful beaches in Pedasí. This unique retreat offers a blend of modern luxury and coastal charm, ensuring an unforgettable vacation experience for you and your loved ones. Book your stay today and experience the magic of Casa Serena. Create lasting memories with your family and friends in this perfect ocean view escape.

Casa Gerard
A stylish, modern beach house perched above the Pacific Ocean and a large stylish pool. Ample space with 3 bedrooms with en-suite bathrooms, large open living space with a fully equipped kitchen, giving onto a large wooden deck. A beach house with a pool in a modern style located on the hill overlooking the Pacific Ocean. It has 3 bedrooms, each with its own bathroom. It has an open living room and a well-equipped kitchen. It has a large deck to enjoy.

Casa Samambaia - sea view tropical paradise w pool
With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

Country House Like in the City / La Casita
Casa fresca, con árboles, naturaleza y portales p/ descansar, cámaras de seguridad afuera Ubicación céntrica, cerca de malls, restaurantes, buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Contamos con un pozo de agua y sistema de purificación de agua por ósmosis inversa: agua segura, potable y purificada!

A minimalist Casita in Pedasi
Imagine a peaceful casita with ocean views and a nearby pool house boasting an edgeless pool overlooking the ocean. Plus, you have your own private beach. Inside, you will find an open-concept living space adorned with simple yet stylish furnishings, designed for relaxation and comfort. It's the perfect blend of tranquility, peaceful seclusion and breathtaking natural beauty. Gated community, 24 hour security

Casa Inito - Romantic Getaway
Indulge in the charm of Casa Inito, a thoughtfully crafted haven that invites you to experience a one-bedroom retreat like no other. This well-designed space seamlessly blends modern comfort with an intimate setting, creating the perfect atmosphere for your getaway. The Villa is located just 7 minutes from Playa Venao Beach (by car). ****(Vehicle a MUST, preferably SUV due to steep paved access road)****
Popular amenities for house rentals in Los Santos Province
House rentals with a pool

Modern Beach Home with pool and hot tub

Yellowfin Casa 3

Beachfront home on Playa Venao + private pool

2/2 Private Oasis Pedasi's best location & rental!

Dorado Retreat Estate in Cañas

Peaceful Pedasi

Casa Del Amor - Main Floor - on the beach.

Casa Maitri: Panoramic Ocean View, Pool, Near Surf
Weekly house rentals

Beautiful House in Chitre with Pool

Pedasí, Earth House Casa Alegre / 3BR

Entire house -7 min from Las Tablas

Beautiful House for Rent in Downtown Chitré

Yayo's Place

CASA ROSA 49' - Venao Beach

Concha House at Luna Negra

La Casita 4BR Spacious Private Paradise w/pool
Private house rentals

Casa Amarilla-Cozy 2Bed/1Bath/Pocri, Las Tablas

House "Las Marias" / Renewed bathroom

Hacienda Ojo de Agua * Family & Friends Getaway

3- Las Tablas Comfy and Spacious Private Room

Casa Iguana 2 - 2 queen beds, 2 sets bunk beds

Minimalist House In Chitre

Casa Centenario

House in Las Tablas, with a swimming pool and beach access
Destinations to explore
- Hotel rooms Los Santos Province
- Flat rentals Los Santos Province
- Smoking-friendly rentals Los Santos Province
- Beachfront rentals Los Santos Province
- Family-friendly rentals Los Santos Province
- Rentals with a patio Los Santos Province
- Apartment rentals Los Santos Province
- Pet-friendly rentals Los Santos Province
- Rentals with beach access Los Santos Province
- Rentals with an accessible-height bed Los Santos Province
- Rentals with outdoor seating Los Santos Province
- Bed and breakfasts Los Santos Province
- Waterfront rentals Los Santos Province
- Rentals with pools Los Santos Province
- Rentals with a washing machine and dryer Los Santos Province
- Rentals with a hot tub Los Santos Province
- Rentals with a firepit Los Santos Province
- Villa rentals Los Santos Province
- Guest house rentals Los Santos Province
- Boutique hotels Los Santos Province
- House rentals Panama




