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House holiday rentals in Los Santos Province

Find and book unique houses on Airbnb

Top-rated house rentals in Los Santos Province

Guests agree: these houses are highly rated for location, cleanliness and more.

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Guest favourite
A charming beach house is surrounded by lush greenery and palm trees, elevated on sturdy pillars. The thatched roof complements the tropical setting, while large windows provide ample natural light. A spacious wooden deck with railing enhances the inviting outdoor space.
Home in Cambutal
4.86 out of 5 average rating, 37 reviews

Seaside Sanctuary • Steps to Surf • Fast Internet

Wake up to the rhythmic sounds of waves steps from your bed in this intimate beachfront paradise. Our charming one-bedroom home sits directly on Cambutal's pristine shoreline, offering ocean views and instant beach access. Relax on your private terrace with morning coffee as the sun rises, cook meals in the fully-equipped kitchen, and fall asleep to the soothing sounds of the surf. With Starlink internet, you can stay connected while experiencing the perfect blend of seclusion and convenience.

Guest favourite
A charming patio is visible, featuring colorful hammocks suspended beneath a traditional roof. Lush greenery frames the view, enhancing the serene outdoor space that encourages relaxation. The exterior of the home is simple yet inviting, with wooden accents and large windows.
Home in Playa El Agallito
4.9 out of 5 average rating, 20 reviews

El Refugio: Nature Escape in Chitre

El Refugio at Playa El Agallito, Chitré: Nature Escape: Just 7 minutes from downtown Chitré, El Refugio is a fully equipped countryside home, perfect for disconnecting in a natural setting. Surrounded by mangroves and accommodating up to 8 guests, it offers a unique experience for couples, families or digital nomads. Enjoy bird watching, the peaceful surroundings, and the comfort of our large gazebo. Ideal for those seeking simple relaxation and a close connection to nature. A unique experience

Guest favourite
A private pool is framed by a stone patio, surrounded by lush greenery and tropical plants. A shaded area features outdoor seating and a grill, while the enclosed space provides a sense of tranquility. The home is visible in the background, set against a clear blue sky.
Home in Pedasí
4.92 out of 5 average rating, 199 reviews

3 min to Pedasi, 5 min to the Beach, Private Pool!

Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Superhost
A welcoming entrance is framed by vibrant tropical plants, with a pathway leading to a covered porch. The structure features a tiled roof and red steps, providing an inviting transition from the outdoors to the interior space.
Home in Pedasi
4.85 out of 5 average rating, 20 reviews

Peaceful Pedasi

Peaceful Pedasi. Get completely away from the city and forget the rest of the world exists. Pedasí is a town and corregimiento situated on the south-eastern tip of the Azuero Peninsula on Panama’s Pacific coast. And although remote enough to feel protected from the stresses of life, Pedasi offers wonderful dining and shopping. Our home offers a full functioning kitchen, large dining space, 5 Bedrooms, 4 Bathrooms, 2 car garage, private pool, and cabana with your own view of the ocean.

Superhost
The house exterior features a warm peach-colored facade with a large white-framed window. Tropical palm trees and vibrant flowering shrubs border the front, providing a refreshing touch to the entrance.
Home in Chitre
4.81 out of 5 average rating, 80 reviews

NinaHouse, spacious and cool house in Chitré.

House just for you, now with a water tank! Up to 7 people, spacious and in one of the best areas of Chitré, quiet and family-friendly, access to the pool in the social area, parks and courts, close to everything: supermarkets, casino, bus; come to Chitre and enjoy typical meals, crafts; plan your walks and visit the best beaches: Pedasi, Venao, Isla Iguana, you can work from NinaHouse with fast internet. We now have air conditioning in the living room for your comfort.

Superhost
A private pool is surrounded by outdoor loungers, providing a spacious area for relaxation. The modern house features large glass doors that invite natural light, showcasing a harmonious blend of indoor and outdoor living spaces. Lush greenery is visible in the background.
Home in Punta Mala
4.84 out of 5 average rating, 19 reviews

Pedasi Coast, Casa Calma / 3BR

❤ Welcome to Casa Calma, enjoy this beautiful house ideal for groups of up to 6 people. With 3 comfortable and bright rooms, each equipped to guarantee your rest and comfort. The jewel of the house is its direct access to the sea, perfect for cooling off at any time of the day. In addition, you will have access to a private pool with a large terrace where you can enjoy spectacular sunrises and relax to the sound of the waves. Embark on this unique new adventure! ✿

Guest favourite
A modern tropical home is set amid lush greenery, featuring an expansive deck that connects to a serene pool. Large glass doors provide a view of the inviting interior and allow natural light to fill the space. Mountains and trees frame the backdrop.
Home in Playa Venao
4.97 out of 5 average rating, 77 reviews

Casa Samambaia - sea view tropical paradise w pool

With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

Superhost
Home in Playa Venao
4.89 out of 5 average rating, 75 reviews

Casa Pelicano - Tropical house w pool and seaview

Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

Superhost
A single-story house is nestled beneath a large tree, featuring a tiled roof and a covered parking area. Surrounding greenery includes bushes and ornamental plants, enhancing the natural setting. The house is positioned to provide a sense of privacy and tranquility.
Home in Chitre
4.87 out of 5 average rating, 67 reviews

Country House Like in the City / La Casita

Casa fresca, con árboles, naturaleza y portales p/ descansar, cámaras de seguridad afuera Ubicación céntrica, cerca de malls, restaurantes, buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Contamos con un pozo de agua y sistema de purificación de agua por ósmosis inversa: agua segura, potable y purificada!

Guest favourite
The outdoor area features a spacious infinity pool surrounded by a sun deck, complete with lounge chairs. Lush greenery and palm trees can be seen in the background, under a bright blue sky with fluffy clouds, creating a serene outdoor retreat.
Home in Pedasí
4.96 out of 5 average rating, 23 reviews

Villa La Jungla featuring a New Pool

Escape to this serene, private retreat just minutes from Pedasí, Playa Venao, and stunning beaches. Perfect for 4–8 guests, the home features spacious en-suite bedrooms with quality linens, a fully equipped kitchen, and a newly resurfaced infinity pool. Enjoy total privacy, comfort, and easy access to local adventures. Whether you're here to surf, explore, or relax, this is your ideal home base for a peaceful and memorable stay.

Top guest favourite
The exterior of a casita is displayed, featuring a light-colored facade with a red-tiled roof. A silver SUV is parked on a stone pathway that leads to a wooden front door. Lush greenery and palm trees are visible in the background under a partly cloudy sky.
Home in Pedasi
4.9 out of 5 average rating, 31 reviews

A minimalist Casita in Pedasi

Imagine a peaceful casita with ocean views and a nearby pool house boasting an edgeless pool overlooking the ocean. Plus, you have your own private beach. Inside, you will find an open-concept living space adorned with simple yet stylish furnishings, designed for relaxation and comfort. It's the perfect blend of tranquility, peaceful seclusion and breathtaking natural beauty. Gated community, 24 hour security

Guest favourite
A colorful hammock hangs between two posts on a wooden terrace, overlooking a vast landscape. The sun sets in the distance, casting a warm glow over the scene, framed by lush greenery and bamboo fencing that adds privacy.
Home in Provincia de Los Santos
4.95 out of 5 average rating, 20 reviews

Casa Inito - Romantic Getaway

Indulge in the charm of Casa Inito, a thoughtfully crafted haven that invites you to experience a one-bedroom retreat like no other. This well-designed space seamlessly blends modern comfort with an intimate setting, creating the perfect atmosphere for your getaway. The Villa is located just 7 minutes from Playa Venao Beach (by car). ****(Vehicle a MUST, preferably SUV due to steep paved access road)****

Popular amenities for house rentals in Los Santos Province