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Apartment holiday rentals in Panama Canal

Find and book unique apartments on Airbnb

Top-rated apartment rentals in Panama Canal

Guests agree: these apartments are highly rated for location, cleanliness and more.

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Guest favourite
Flat in San Felipe
4.96 out of 5 average rating, 260 reviews

In the heart of Casco, refurbished and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Guest favourite
Flat in Panama City
5.0 out of 5 average rating, 8 reviews

Studio for the Coffee-Obsessed | near Casco Viejo

Panama produces some of the world's most celebrated coffees — and this studio puts you right where the flavor meets the culture. A third-floor, well-designed space in Santa Ana, walking distance from Casco Viejo and a short trip from the best specialty cafés in Panama City. 📍 Location (Important – Please Read) The studio is NOT inside Casco Viejo, but: • 2–3 minutes by Uber ($2–$3) • 8–10 minute walk Santa Ana has a long café culture of its own — and the specialty coffee scene nearby is genui

Top guest favourite
Flat in San Felipe
4.98 out of 5 average rating, 130 reviews

The View of Casco: Designer Loft with best Balcony

Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! ​Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. ​You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

Guest favourite
A modern living area is featured, showcasing a large wall-mounted television surrounded by a lighted panel. Seating is provided by a dark sofa with decorative pillows. A round dining table is visible in the foreground, complemented by four black chairs. Tall windows offer city views.
Flat in Panama City
4.86 out of 5 average rating, 71 reviews

Luxury Oceanfront Resort 22nd Floor View, 200°

Luxury oceanfront apartment on the 22nd floor with breathtaking panoramic views of Panama Bay, the skyline, and historic Casco Antiguo. Located on the famous Cinta Costera, this resort-style apartment offers 2 bedrooms, 2 bathrooms, luxury kitchen, 65” TVs, washer/dryer, and sleeps up to 6 guests. Enjoy spectacular sunsets from the balcony and access to infinity pool, gym, and premium amenities, just minutes from restaurants, nightlife, and Panama City’s top attractions.

Guest favourite
Flat in Panama City
4.97 out of 5 average rating, 93 reviews

Ocean View | Rooftop Pool | Luxury Stay

Wake up to a stunning ocean view right from your window at BrisaMarina. This luxury apartment is located in the spectacular The Sands building, right on the Cinta Costera. The modern and cozy space features bright natural light, air conditioning, high-speed Wi-Fi, and a fully equipped kitchen for your comfort. You’ll be just minutes away from restaurants, beaches, and top attractions. Perfect for couples, business travelers, or weekend getaways.

Top guest favourite
An inviting living area is featured, showcasing a modern grey sofa accented with decorative pillows. A round glass dining table is surrounded by chairs, and artistic wall frames complement the space. Natural light is filtered through elegantly layered window shades.
Flat in Bella Vista
4.92 out of 5 average rating, 174 reviews

Luxury apartment in downtown Panama, banking area

We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

Superhost
Flat in San Felipe
4.88 out of 5 average rating, 433 reviews

3B Mola Studio | Design By Paradox

Private 40 m² design studio in Santa Ana, about a 5-minute walk from Casco Viejo. Mola Space sleeps up to 3 guests with a Queen bed and sofa bed, and includes a full kitchen, private bathroom, air conditioning, hot water, fast WiFi, dining space, and a 1.8 m desk. Enjoy a projector with Roku and host-provided Netflix, Disney+, Max, and Prime. Guests have access to the shared balcony, patio, and paid laundry.

Guest favourite
Flat in San Francisco
4.98 out of 5 average rating, 163 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Guest favourite
Flat in Panama City
4.89 out of 5 average rating, 142 reviews

Modern, central and comfortable (001)

Modern and cozy studio in the heart of Panama. Perfect for exploring the Old Town, the Coastal Strip and more. Full kitchen, full bed, double sofa bed, air conditioning, fast WiFi and private bathroom. Ideal for 1–4 people. Private access, elevator and self check-in. Surrounded by restaurants, transportation, and tourist sites. Your ideal base to explore the city!

Guest favourite
Flat in Panama City
4.92 out of 5 average rating, 71 reviews

Old Town & Ocean View

Stunning views of the sea and the Old Town, with direct access to the Poin Panamá resort, as well as a variety of dining options and bars, for an unparalleled holiday experience. ⚠️ Important notice: The building's pool and gym will be temporarily closed for maintenance work from 24 August to 15 September 2026. Thank you for your understanding.

Guest favourite
Flat in Panama City
5.0 out of 5 average rating, 15 reviews

Panama City Sea View

Stunning views of the sea and the Old Town, with direct access to the Poin Panamá resort, as well as a variety of dining options and bars, for an unparalleled holiday experience. ⚠️ Important notice: The building's pool and gym will be temporarily closed for maintenance work from 24 August to 15 September 2026. Thank you for your understanding.

Guest favourite
Flat in Panama City
4.84 out of 5 average rating, 32 reviews

Ocean View Suite Coastal Strip

Stunning views of the sea and the Old Town, with direct access to the Poin Panamá resort, as well as a variety of dining options and bars, for an unparalleled holiday experience. ⚠️ Important notice: The building's pool and gym will be temporarily closed for maintenance work from 24 August to 15 September 2026. Thank you for your understanding.

Popular amenities for Panama Canal apartment rentals