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Holiday rentals in Santa Clara, Panama City

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Top-rated holiday rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Flat in Panamá
4.93 out of 5 average rating, 129 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Superhost
A spacious outdoor area features wooden dining tables surrounded by potted plants. The space includes a plunge pool, comfortable seating, and a hammock for relaxation, with views of the nearby structures and the sky above.
Flat in Panamá
4.87 out of 5 average rating, 388 reviews

Casco Viejo 360° View Old Tower Penthouse

Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Guest favourite
A comfortable sleeping area is presented with a spacious bed covered in a soft, patterned blanket. Lively artwork featuring tulips adorns the wall above, while bedside tables with lamps provide gentle illumination. Dark curtains frame the window, and air conditioning is installed overhead.
Loft in Panama
4.95 out of 5 average rating, 59 reviews

Entire Apartment #4, 20 minutes from the airport

Comfortable and cozy apartment on Av. la Pulida, 8 minutes from the Cincuentenario metro station. For business travelers and couples, this apartment features a bedroom with a full bed, a TV in the room, a full bathroom with hot water, a fully equipped kitchen, a living-dining room, a Smart TV, air conditioning, a laundry room, and a closet. It's just 8 minutes from the metro station and offers easy access to any point in the city. Centrally located, yet quiet. Enjoy a perfect stay!

Top guest favourite
Flat in Panamá
5 out of 5 average rating, 13 reviews

Luxury Balcony Stays + Pool Casco Viejo

Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Superhost
A spacious bed is presented with a neatly arranged white bedspread, complemented by light wooden nightstands on either side. Each nightstand features a lamp providing soft illumination, enhancing the calming atmosphere of the room.
Flat in Panamá
4.78 out of 5 average rating, 27 reviews

chanis-apto-wifi-kitchen-tv-streaming-panamaviejo

Hello 😇 I want you to feel at home! This accommodation is cozy, quiet and centrally located. Its prime location will allow you to explore the city with ease. Its location in downtown Chanis, the accommodation offers peace and quiet. Ideal for three people looking for a pleasant stay. Relax in a cozy and comfortable atmosphere. with easy access to large shopping areas, it is 5 minutes away from the east coast (tourist) and also the ruins of Panama

Guest favourite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.92 out of 5 average rating, 159 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Guest favourite
A spacious balcony offers a panoramic view of Panama City's skyline, with a backdrop of dramatic clouds and sunlight illuminating the scene. A modern swing chair sits alongside a potted plant, inviting relaxation among the urban landscape.
Flat in Panamá
4.92 out of 5 average rating, 38 reviews

Luxury Suite 18th View Coco del Mar Panama

Immerse yourself in the elegance and comfort of this beautiful apartment located in the heart of Panama. With stunning views of the ocean and the city, it is designed to provide you with a unique experience. Equipped with top-notch amenities such as a pool, gym and social areas, this space guarantees a stay full of tranquility, luxury in this haven of tranquility and exclusivity. Your home away from home!

Superhost
The living area features a light blue accent wall and a cozy gray sectional sofa accompanied by a round ottoman. A large window with striped awnings allows natural light to fill the space. Wall art and a small shelf with a clock add functional decor.
Flat in Distrito de Panamá
4.79 out of 5 average rating, 24 reviews

Hippodrome Suites

Hippodrome Suites is located in a safe gated community in the suburbs of Panama City, just a short drive 🚘 from the Tocumen International Airport (✈️PTY), Santa Maria and Costa del Este Budiness District. City views, 24-hours security and covered parking. It is ideal for resting and working, business trips or layover nights. This condo offers a perfect mix of comfort, convenience, and tranquility.

Guest favourite
The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.
Home in Panamá
4.94 out of 5 average rating, 406 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Top guest favourite
A spacious living area is highlighted by large windows that offer views of urban high-rises and the distant ocean. A soft, rounded sectional sofa and a plush armchair provide comfort, while a dark area rug anchors the space beneath a sleek coffee table.
Flat in Costa del Este
5 out of 5 average rating, 29 reviews

Elegant Apt in Costa del Este. Premium Amenities

Enjoy a luxurious stay in our modern design apartment located in the exclusive Costa del Este area. It has a room with a private bathroom, a cozy living room, and a fully-equipped kitchen. Building facilities include a state-of-the-art gym, swimming pool, and co-working space ideal for remote work. Perfect for extended stays, combining comfort and convenience in the heart of Panama.

Top guest favourite
Flat in Panama City
5 out of 5 average rating, 19 reviews

Luxury Centric 2BR Apartment in Casco Viejo

Welcome to our charming and spacious apartment in the heart of Casco Viejo. We are located directly across the street from the landmark Hotel La Compañia. From the balcony you can look at the remaining structure of the centuries-old La Compañia de Jesus, a former Jesuit temple and convent. In the apartment, you can relax in the spacious and comfortable space.

Guest favourite
Flat in Costa del Este
5 out of 5 average rating, 11 reviews

Apt 2BR Panama Costa del Este

Enjoy the perfect combination of style and comfort in this elegant two-bedroom, two-full-bathroom apartment, ideal for families, executives, or small groups. Located in Costa del Este, one of Panama City's most exclusive and safest areas, you'll have quick access to business centers, restaurants, supermarkets, and much more.

Popular amenities for Santa Clara, Panama City holiday rentals

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. San Miguelito
  5. Santa Clara