House holiday rentals in Cape Girardeau

Urban Cape Downtown Escape-The Rivertown Nook

Welcome to The Rivertown Nook, your downtown escape into the heart of Cape Girardeau! Centrally located, this stylish one-story retreat is perfect for couples or small families. Walk to local eateries, breweries, coffee shops, and take in Broadway Street’s charm, or take a quick drive to Southeast Missouri State University. The cozy, modern home features a sleek kitchen, spa-like bathroom, and off-street parking. Whether for a weekend or vacation, it's the perfect base to explore Cape Girardeau!

Cape Charm: 3 BR Close to SEMO & Mercy! CLEAN!

Cape Charm is a "charming" 3 BR home in a safe, quiet neighborhood perfectly located next to SEMO, Mercy Hospital, Capaha Park & the historic district - all less than a 7 minute walk! Feel at home in a magnificently cute 3 bedroom home (w/king bed), fully equipped kitchen, living room, dining room, bathroom, & sun room. Free, fast WIFI, a smart TV in the living room & bedroom. It's centrally located to everything! We are experienced hosts with highly rated listings in Florida and Missouri.

Historic Riverside Getaway

Step into a beautifully restored early 20th-century gem, where classic architecture meets cozy, modern interiors. Sip your morning coffee on the balcony with river views, unwind in a stylish lounge, and enjoy the warmth of wood floors, plush rugs, and curated decor. With a full kitchen, spacious bathroom, and serene bedroom, this space is perfect for couples, solo travelers, or remote workers seeking peace and character. Book your stay where comfort and charm meet right in the heart of downtown

4 mins to Bourbon Bar, hot tub, wine trail, views

Escape your worries in this spacious, serene retreat. Whether your exploring the local wineries, embarking on a girl’s trips, hiking scenic trails, enjoying a family vacation, or even casting a line on a fishing trip, our home is the perfect destination. After a day of adventure, unwind in the comfort of our well-appointed space. End your day by the pool, soak in the hot tub, or enjoy a campfire. Located just a short distance from Bald Knob Cross. Cameras actively recording at all times.

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Elegant Home Near Hospital

Welcome to our elegant and charming getaway, just blocks from the local hospital and university! This cozy, character-filled 100+ year old home blends historic charm with modern comfort. Featuring 2 bedrooms and an updated bathroom. You’ll enjoy the open-concept living and dining area, thoughtfully designed for comfort and connection. Relax in the bright enclosed sun porch, ideal for reading, morning coffee, or board games. Book your stay today; comfort, convenience, and character await!

The Farmhouse in Rhine Valley

Newly renovated Farmhouse in Alto Pass situated between Trail of Tears State Forest and just a hike or short drive away from Bald Knob Cross and wilderness. Minutes away from local wineries. Enjoy a peaceful pause from the hustle and bustle in our private little Farmhouse. Perfect for single family or small groups. Nearby venues and activities include: hiking, fishing, public hunting, wineries, restaurants, and many other local venues and events. Hunters are welcome.

Cozy Artistic Downtown Loft

Charming downtown loft with cozy vintage vibes and artistic touches. Walkable to shops, dining, and nightlife. Perfect for solo travelers, couples, or creatives. Includes a queen bed (upstairs), full bath, and private entrance with parking. Ideal for a weekend escape or longer stay. 🎯 Whether you’re a traveling nurse, remote worker, or just here for a weekend escape—this loft has you covered with charm, comfort, and convenience. Available for extended stays also.

Tiny Cozy Apt. in Cape Girardeau MO

Welcome to our Brand new cozy & tiny apt. attached to our house ! You are going to have an entire space for yourself with private entry ! You can almost drive to everywhere within 5mins-10mins in Cape Girardeau/Jackson , and very peaceful and quiet neighborhood. Very close distance to some restaurants, gas station, and Cape trail to take a walk or bike ride. You might see some deer in our front / back yard in the evening

The Wooded Walnut House

Escape to our charming home nestled among majestic walnut and oak trees on a spacious lot in Cape Girardeau! We've created a welcoming retreat that combines the tranquility of nature with unbeatable convenience - complete with a lovely deck and patio for outdoor relaxation - just minutes from historic Downtown Cape Girardeau, Southeast Missouri State University, and Capaha Park (home of SEMO and Cape Catfish Baseball).

Herman’s Cottage on the Corner

This beautifully remodeled 2 bed/1 bath home offering modern comfort and total convenience. Enjoy central air, stylish furnishings, and high-speed internet. The home features keyless entry, a fully fenced backyard, and a BBQ grill perfect for relaxing evenings. Conveniently located near shopping, dining, and local attractions. Fully furnished and move-in ready, this space is ideal for comfortable, hassle-free living.