
House holiday rentals in Lake City
Find and book unique houses on Airbnb
Top-rated house rentals in Lake City
Guests agree: these houses are highly rated for location, cleanliness and more.

Kuker Cottage Downtown Florence-Near I95 & I20
Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Luxury Lakefront Chalet W/Pool, Hot Tub & Beach
Bring the whole family to this gorgeous lakefront chalet with tons of guest amenities in a quiet neighborhood on Wyboo Creek. Sleeps 2 families comfortably w/ 4 large BR, 2 bathrooms, a game room, a fully equipped kitchen, living area, & screened porch. Enjoy the in ground pool w/ tanning ledge, hot tub, built-in fire pit, outdoor grilling & dining area, private sandy beach, & pier on open water. Launch your boat at the public ramp at the end of the street (.2 miles) & dock at the private pier.

Renovated 2 BR/2 B Townhouse Cozy & Clean
Keep it simple at this peaceful, centrally-located, and renovated townhouse close by I-95 and I-20 and within 15 mins. to the Florence Center, downtown Florence, many restaurants, and McLeod and MUSC Florence. House is located in a safe neighborhood with 2 queen beds and 1 sofa bed in the living room. Enjoy being outdoors? Relax outdoors on your own private patio, go on a walk around the neighborhood, or go on an adventure. The Rail Trail & Ebenezer Park are minutes away. Utilities included.

magical 1840s farm house getaway
Centuries old country estate with magical ambiance, art and antiques, beautiful views and wrap around porches. Relax in the hot tub in your own private oasis or gather with friends and family around the fire pit. Multiple bird feeders and grand live oaks, magnolias, fruit trees and a kitchen garden. Chefs kitchen will be stocked with fresh eggs, herbs and seasonal veggies. Sit and sip on the porch while enjoying the views of farmer's field and listing to the moos of the cows. Groups welcome!

Carolina Wren Cottage: New, Relaxing, Dog-Friendly
Charming dog friendly cottage located minutes away from historic Georgetown only about an hour from Charleston. Whether you want to sit on the large porch and enjoy listening to the birds sing or watch them fly back and forth through the beautiful trees. Maybe have an adventure walking along the Harbor walk do a little shopping and enjoy the great selection of restaurants. If that wasn't enough there are several beautiful beaches to enjoy. You won't be disappointed. For pets see policies.

Black River Refuge on the Water
The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

Charming Home in Florence, SC
Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

The Parkside Retreat
Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

Quiet Country Living w/private lot
Welcome to Quiet Country Living! Experience all that Sumter has to offer with this renovated home that has everything you will need for your stay. Located in a country neighborhood only 8.9 miles from downtown, local shops, Swan Lake Iris Gardens, and other parks and attractions. Also 19.4 miles to Shaw Air Force Base. Business friendly, military friendly, family friendly. Home available for temporary duty (TDY) . This location is perfect for any and all travelers.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Highway Oasis and Myrtle Beach
Welcome to this charming new house ideally situated close to both a major highway i 95 and i20 and the serene Myrtle beach, offering the perfect blend of convenience . Nestled in a great neighborhood, this residence boasts easy access to shopping center, ensuring that all your daily needs are just moments away. Very close to Florence Civic Center, 15 minutes to Buc-ee's Myrtle beach in 1 hr of a drive and shopping amenities.

Creekside Cottage - 4 Bedrooms
Enjoy your staying on this newly renovated Pet friendly house. Treat yourself with a cup of coffee at the deck while you watch your furry baby play in the big fenced backyard. This house is centrally located in Florence. Only minutes from downtown Florence, Grocery stores, Pharmacies, Restaurants, MUSC Hospital, McLeod Hospital. This house has two king bed bedrooms and two Queen bed bedrooms.
Popular amenities for house rentals in Lake City
House rentals with a pool

Eagle Point Poolside Escape

Huge Pool! Fenced Yard! Pets OK! Close to Beach!

Lakefront Farmhouse Retreat+Pool

Low Country Lux

Eagle Point Retreat W/Pool

Wyboo Retreat at Lake Marion W/Pool

Lakeview Leisure-Face to the Sun

Quiet Retreat:Secluded & Idyllic
Weekly house rentals

Cozy hip lakefront condo near downtown Hartsville

Peaceful Pine Stays/ 5 min. from Mcleod hospital

A Lake Slice of Heaven

Hidden Oasis

Almost Heaven on Lake Marion, SC

Cozy 3 Bedroom Home! Located NEAR MUSC-Florence

Fish Haven I

Florence 3Br Ranch
Private house rentals

The Cottage

Spacious 3 bd Home with Office, GameRoom & Balcony

Crystal Place Near MUSC and Mcleod Hospital

Santee/Lizzie's Creek Lakefront

Graceful Comfort

Spacious, Historic Home for 12 - Near Myrtle Beach

Lovely Cottage Close to Downtown w/EV chargers

Cheerful 2bedroom home located Downtown Georgetown
Destinations to explore
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