Holiday rentals in Osborn Medical Center, Phoenix

Best Little Guesthouse in Melrose !

Historic guesthouse in the heart of the Melrose District! EV charger! Walking distance to restaurants, bars, coffee shops, the famous Melrose Vintage shops, grocery stores, LA Fitness and more! Want to head downtown to Chase Field, Talking Stick Arena for a game or a show? Campbell Street Light Rail station is only five short blocks away! No need for a car, you can take the Light Rail from Sky Harbor International Airport, save your money for entertainment! Off street parking if you have a car!

Spacious Midtown guesthouse with full privacy

Welcome to your private casita (tiny home) in the heart of Midtown. Located right across the street from Starbucks, Buffalo Exchange, and the famous Taco Guild, relax comfortably with vaulted ceilings, a spacious layout, outdoor patio, and a quiet bedroom with a Queen-size bed — perfect for solo travelers or couples. Plus, the Light Rail station is walkable, which goes to Uptown, Downtown, the airport, Tempe, and Mesa. You are only: 7 mins to Downtown 9 mins to the Airport 15 mins to Scottsdale

Downtown Historic Bungalow

Cozy 350 sqft back house in the historic downtown Encanto-Palmcroft district. Private entrance through side gate takes you around main house. Minutes from restaurants, coffee, bars, farmers market, & museums! Palm tree lined street perfect for walking. Access to our spacious backyard with BBQ. Kitchenette includes fridge, microwave, toaster, and portable cook top. We are steps away in the main house for anything you need. 10 min from Phx airport, 7 min to Roosevelt Row, PHX area, & downtown Phx

*Private Detached Cottage ~Near Downtown Phoenix!

Beautiful private guest house in the coveted Willo Historic District! This quiet retreat is the ideal location to walk to St. Joe’s and Barrow Neurological Institute. Well appointed studio provides a hotel quality stay w/a bit of warmth and charm. Relaxing backyard space to enjoy our gorgeous weather. Enjoy one of our bikes to ride around the historic neighborhood just north of downtown. Attend conventions, concerts and sporting events easily. We’re centrally located for Spring Training games!

Stunning Historic Adobe in Central Phoenix!

Beautiful, bright, airy, mid-century adobe casita, located and overlooking a walled tropical garden in historic central Phoenix. 10 min from Sky Harbor Airport and located in the very popular and historic Melrose District. 20 restaurants, bars, cafes within 3 blocks walking distance. Wine shops, vintage stores, grocery, and pharmacy within 2 blocks walk. Scottsdale/Downtown Phoenix a very short drive. Furnished with antiques and regional artwork. Wifi, TV, full kitchen, washer/dryer included.

The Glenrosa Gem Pool: Heated pool!

Kick back and relax in this calm, stylish Eco-Friendly home in Central Phoenix. Completely remodeled 3 BR, 3 Bath Home in North Encanto. Centrally Located. A 10 Minute walk to the Melrose District. All the comforts of home. Large kitchen with new appliances. Central A/C. Gas BBQ. HEATED Salt Water Pool. Lovely front and back porches. A large welcoming fun backyard with many relaxation spaces. Stocked with a multitude of in and outdoor games. Pool heating fee of $39/day EV Charging $20/day

PHX's Modern Midtown Carriage House, Free Parking

Experience the perfect blend of historic charm and modern comfort in the heart of Phoenix's Midtown. Our beautifully designed Carriage House offers a unique guest quarters, complete with a full kitchen, luxurious queen bedding, and a private patio. Step outside and explore the vibrant neighborhood, filled with local restaurants, shops, and cultural attractions. Book your stay at the Midtown Carriage House today and discover the best of Phoenix living. check out on insta @midtowncarriagehouse

Poolside Guesthouse with Private Patio in Midtown

Welcome to the Poolside Guesthouse! Everything has been designed with you in mind to help you enjoy your time in Phoenix! Furniture and fixtures have been selected for your comfort and to help maximize the space. The Poolside Guesthouse has fantastic outdoor spaces for you to enjoy our beautiful weather & offers one of the best central locations with easy access to the airport, shopping, arts district, museums, bars and restaurants. TPT License #21525000 City of Phoenix License #2023-4161

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Private, desert-chic casita in vibrant Midtown PHX

Welcome to Casita Amelia, a modern rustic retreat central to all the action Phoenix has to offer. Welcoming and cozy, this newly updated private guest suite has all the luxuries of a modern hotel suite while being quietly tucked away in a cute Midtown neighborhood. Walk to Melrose District. You're also just 5-10 mins by car to Uptown & Camelback Corridor, 10 mins to Downtown (Footprint Center, Chase Field, Arizona Financial), 15 mins to Sky Harbor Airport, and 20 mins to State Farm Stadium.

Private Casita w/ Pool* & BBQ in Historic Melrose

*PLEASE READ HOUSE RULES IN "OTHER THINGS TO NOTE" AREA BEFORE BOOKING* Under no circumstance can one book the Airbnb for another guest . This violates our house rules as well as Airbnb policy. Read more under HOUSE RULES for more details. Our cozy casita is located in the Woodlawn Park neighborhood, a short car ride from the Melrose and Willo Districts. Located near some of the best restaurants in Phoenix, this is the perfect stay for visitors who want to explore the local food scene.

Midtown Casita, Hot Tub, 5 Min to Downtown Phoenix

This boutique, private casita is centrally located in the Historic Coronado Neighborhood of Midtown Phoenix and features a relaxing hot tub. You're right in the center of Phoenix: 8 minute drive to Downtown Phoenix 19 minute drive to Scottsdale 8 minute drive to Sky Harbor Airport *This space was designed with the award-winning team from Anthony W Design. **Many restaurants and cafes are within a ten-minute walk, but a vehicle is recommended for the city of Phoenix. STR-2025-003069