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Holiday rentals in Osborn Medical Center, Phoenix

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Top-rated holiday rentals in Osborn Medical Center, Phoenix

Guests agree: these stays are highly rated for location, cleanliness and more.

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The living area features a blue velvet sofa with decorative cushions, complemented by a round yellow coffee table. Natural light enters through the window, illuminating the exposed brick wall and modern kitchen with stainless steel appliances and a breakfast bar.
Apartment in Encanto
4.92 out of 5 average rating, 142 reviews

Hip, Pet & Work Friendly 1Bed, Near Food & More

Location is in the middle of all the Cactus League Spring Training action. Welcome to our stunning 1 bedroom/1 bathroom home near Central Downtown Phoenix! Located in an up and coming, urban neighborhood with access to public transit. At our location, you’re never far from your next adventure. We offer a pet-friendly environment, blazing FAST WiFi for all of your work needs, onsite parking, a fully stocked kitchen, SmartTV, and more! This is the perfect place to call your home away from home.

Top guest favourite
An inviting pool area features a spacious swimming pool surrounded by lounge chairs and tropical palm trees. A shaded patio with seating overlooks the pool, providing a relaxing outdoor space. The area is enclosed by a wooden fence and has landscaped greenery for added privacy.
Home in Encanto
4.97 out of 5 average rating, 231 reviews

Paradise Found, Conferences, Concerts, GCU, Pool

The historic Willo district of Central Phoenix is the perfect location to relax. Close to many attractions and major freeways, this completely renovated mid-century home offers the ultimate in both luxury and high-end fixtures. Inside, you can pamper yourself in the deep tub (with endless hot water) or multi-faucet shower, snuggle in the luxurious beds, or just laze in front of the 65" 4K TV. Outside, you can relax beside the pool (ask about heating), or just gather under the shaded patio.

Top guest favourite
A modern kitchen space is highlighted by a red retro-style refrigerator and a large island with two black stools. Greenery is present, adding a touch of nature, while natural light fills the area through nearby windows. Warm wood accents frame the space.
Guest house in Encanto
4.99 out of 5 average rating, 99 reviews

Luxe Historic Casita w/ Free Parking: Casa Pascual

NEW! Welcome to Casa Pascual, a 1938 casita in Phoenix’s historic Willo neighborhood. This elevated cozy retreat blends Southwest style with Latin warmth, featuring clean lines, earthy tones, and natural accents. Enjoy a serene escape while being close to Encanto Park, the Heard Museum, and downtown Phoenix. Experience a perfect mix of comfort and cultural richness, with easy access to local attractions and a peaceful atmosphere to return to after exploring the vibrant area. IG: casapascualphx

Guest favourite
The living area features a stylish brown sofa adorned with decorative pillows, accompanied by a coffee table. A large window offers views of greenery, while natural light brightens the space. The room includes modern decor and a small dining table for two.
Flat in Phoenix
4.94 out of 5 average rating, 128 reviews

King Size Bed Lavish Uptown Phoenix Suite!

Stylish 1 Bedroom in centrally located Uptown! The best of Phoenix is at your doorstep. Enjoy one of many unique breweries, restaurants, speakeasies & coffee shops right around the corner from your lavish suite. A true hikers paradise as you are nestled in-between all of the majestic mountains. Catch a game at spring training, Diamondbacks, Cardinals, or Coyotes stadiums 10 minutes away. Enjoy Scottsdale right next door! Or best of all, enjoy a staycation with all of the resort style amenities.

Top guest favourite
Guest house in Encanto
4.97 out of 5 average rating, 237 reviews

PHX's Modern Midtown Carriage House, Free Parking

Experience the perfect blend of historic charm and modern comfort in the heart of Phoenix's Midtown. Our beautifully designed Carriage House offers a unique guest quarters, complete with a full kitchen, luxurious queen bedding, and a private patio. Step outside and explore the vibrant neighborhood, filled with local restaurants, shops, and cultural attractions. Book your stay at the Midtown Carriage House today and discover the best of Phoenix living. check out on insta @midtowncarriagehouse

Top guest favourite
A swimming pool surrounded by a white wall features a pebble tech finish. Two lounge chairs are positioned on the edge of the pool, with green grass along one side. Bright sunlight reflects off the water, creating a shimmering effect.
Guest house in Encanto
4.97 out of 5 average rating, 154 reviews

Poolside Guesthouse with Private Patio in Midtown

Welcome to the Poolside Guesthouse! Everything has been designed with you in mind to help you enjoy your time in Phoenix! Furniture and fixtures have been selected for your comfort and to help maximize the space. The Poolside Guesthouse has fantastic outdoor spaces for you to enjoy our beautiful weather & offers one of the best central locations with easy access to the airport, shopping, arts district, museums, bars and restaurants. TPT License #21525000 City of Phoenix License #2023-4161

Top guest favourite
The exterior of a charming studio guesthouse is visible, showcasing a brown brick facade and a well-kept entrance. A small pathway leads to the door, and palm trees can be seen in the background against a bright blue sky.
Guest house in Phoenix College
4.97 out of 5 average rating, 1,313 reviews

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Top guest favourite
A cozy bedroom featuring a spacious bed with a custom leather headboard. A large black and white mural of cacti adds character to the room. A modern pendant light hangs above, complementing the warm tones of the wooden bed frame and the textured beige bedding.
Guest suite in Encanto
4.99 out of 5 average rating, 390 reviews

Private, desert-chic casita in vibrant Midtown PHX

Welcome to Casita Amelia, a modern rustic retreat central to all the action Phoenix has to offer. Welcoming and cozy, this newly updated private guest suite has all the luxuries of a modern hotel suite while being quietly tucked away in a cute Midtown neighborhood. Walk to Melrose District. You're also just 5-10 mins by car to Uptown & Camelback Corridor, 10 mins to Downtown (Footprint Center, Chase Field, Arizona Financial), 15 mins to Sky Harbor Airport, and 20 mins to State Farm Stadium.

Top guest favourite
Guest house in Phoenix
4.95 out of 5 average rating, 593 reviews

Spacious Studio in Uptown Historic Neighborhood

Discover Uptown Phoenix and its vibrant charm! Nestled in the historic district, our property offers a serene escape in the heart of the Valley. This spacious, private studio features a resort-style outdoor retreat, a shared courtyard, a gourmet grill, two outdoor dining areas, and a cozy fire pit to unwind. Inside, relax in a comfortable living room, enjoy meals or card games at the dining table, and retreat to a glamorous bedroom for the perfect end to your day.

Guest favourite
Apartment in Encanto
4.88 out of 5 average rating, 190 reviews

The Beverly Bungalow | Stylish Stay Near Downtown

Relax & unwind at our mid-century bungalow in the heart of Phoenix. This 1BR/1BA condo will comfortably sleep 2. Our condo is complete with a full kitchen, cozy living room & dedicated work space for the WFH professional. Also included is a shared pool/hot tub to cool off on those hot summer days. Located in Midtown center to museums, unique bar & restaurant concepts, Chase Field, The Footprint Center - the list goes on. We hope you enjoy all AZ has to offer!

Guest favourite
A cozy living area features a brown leather sofa and an armchair in light green. A glass coffee table is centered in front, reflecting light from nearby windows with sheer curtains. Decorative throw pillows and a mirror with a metallic frame enhance the inviting space.
Home in Ashland Place
4.99 out of 5 average rating, 326 reviews

Marta's Cozy Brick Home in Midtown PHX

Centrally located condo in a beautiful neighborhood with detached carport. Completely renovated and tastefully decorated. Cleaned following the guidelines recommendations from the CDC to prevent spread of COVID-19 and with HEPA air purifier. Cozy Tuft and Needle beds and fully equipped kitchen. Private patios. In walking distance to a variety of restaurants and The Valley Metro Light Rail. City of Phoenix Short-Term Rental Operating Permit # STR-2025-000722

Top guest favourite
The hillside home is framed by lush landscaping, featuring various desert plants including tall cacti and palm trees. A manicured lawn leads up to the house, which showcases large windows that reflect the surrounding beauty.
Home in Phoenix
4.98 out of 5 average rating, 128 reviews

The ViewPointe! Mountain & Cityscape

Stay here and immerse yourself in the natural romantic beauty of Arizona. Enjoy not only stunning mountain views but also the cityscape of downtown Phoenix. With walls of windows bringing the outside in, a spacious living area, king beds, and idyllic private patios, let the beauty of nature be the backdrop for sweet memories in our hillside mid century view home. Only 15 minutes from the airport, our guests love the convenient central city location.

Popular amenities for Osborn Medical Center, Phoenix holiday rentals