Guest house holiday rentals in Pickens County

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Top-rated guest house rentals in Pickens County

Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

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Top guest favourite
A porch swing is set on a wooden deck, adorned with plush cushions featuring intricate patterns. Lush greenery and colorful flowers are visible in the background, adding vibrancy to the serene outdoor setting.
Guest house in Six Mile
4.96 out of 5 average rating, 171 reviews

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Guest favourite
A charming cabin is nestled among towering trees, with a sloped metal roof and rustic log walls. Lush greenery surrounds the property, while vibrant blue hydrangeas bloom in the foreground. A fire pit with seating is positioned to the right, creating an inviting outdoor space.
Guest house in Sunset
4.91 out of 5 average rating, 421 reviews

Mountain Cabin on Creek at Jocassee Gorge.

Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.

Top guest favourite
A rustic cabin is nestled among the trees, with a gravel pathway leading to the entrance. The exterior features wooden siding and a metal roof, complemented by landscaped stones and potted plants. Seasonal decor is present, enhancing the welcoming atmosphere.
Guest house in Pickens
5 out of 5 average rating, 24 reviews

Fairy Forest Cabin with Hot Tub at Table Rock

Adventure and relaxation await you! Set half a mile off the road, surrounded by forest, you’ll feel like you’re far away from the demands of life as you soak in the hot tub. But you are right in the golden corner of SC, NC, GA mountains with the best of hiking, kayaking, cycling and dining nearby! Only 28 miles from Greenville, Clemson and Brevard NC with Table Rock State Park and Lakes Jocassee and Keowee a few minutes away. The perfect couple’s getaway! Use of SC State Park pass included.

Top guest favourite
A spacious living area features a large, L-shaped sectional sofa arranged around a coffee table. A kitchenette with wooden cabinets and appliances is visible in the background, while light flows in through patterned curtains, illuminating the cozy sleeping area with a queen-sized bed.
Guest house in Central
4.97 out of 5 average rating, 190 reviews

Elfwing Carriage House

Bright & comfortable studio apartment located in a quiet family neighborhood in the country, yet minutes to town. We are an easy 15 minute drive to Clemson, less than 5 miles to SWU, 7 miles to Duke Energy. Smart location for the mountains & lakes, visiting colleges, and graduation. Tiger tailgate space available for an additional fee. Hikes, waterfalls, 12 Mile river & Lake Hartwell are nearby. Friendly dogs are fenced or in our home. Come enjoy neighborhood & country living at its finest!

Guest favourite
A spacious living area is presented with high ceilings. A neutral-toned sofa and an armchair are complemented by a coffee table at the center. Colorful artwork, including a world map, adorns the walls, contributing to a vibrant yet relaxing atmosphere.
Guest house in Pendleton
4.88 out of 5 average rating, 278 reviews

La Bella Farm

Do you want to be close to Clemson(11 miles), Anderson(9 miles) OR Greenville(20miles)! Do you want to just get away from all of the noise and busy life. Then you have found your spot! This is a great detached garage apartment. Settled in the quiet country side of Pendleton SC. 1 bedroom&1 bathroom with an additional sofa bed&blow up mattress. Great view of nothing but beautiful land from the kitchen window yet minutes away from Death Valley,restaurants,shopping and 85.

Guest favourite
The exterior of Little Blue is shown, featuring a one-story house with a front porch and steps leading up to it. Surrounding trees display vibrant autumn foliage, while a natural landscape covers the ground, hinting at a serene, countryside atmosphere.
Guest house in Sunset
4.82 out of 5 average rating, 94 reviews

Little Blue Cottage on the Jocassee Wilderness

Little Blue, named because it's surrounded by wild blueberries, is situated just steps from the Jocassee Wilderness Area listed by National Geographic as 9th out of “50 of the World's Last Great Places.” It's located on the property of Heart Ridge Retreat Center. Guests will have access to all the retreat center grounds which includes a well-stocked lake (bring your rod). It's also centrally located to many trails, waterfalls, state parks, and lakes.

Top guest favourite
The exterior of the property is shown, featuring yellow siding complemented by dark shutters on the windows. A single door with glass panels is visible, providing a welcoming entrance. A grassy area is located at the base of the wall, enhancing the outdoor setting.
Guest house in Liberty
4.93 out of 5 average rating, 208 reviews

Holly Hideaway! 10 Highway miles to Clemson U!

Holly Hideaway is nestled between Greenville and Clemson, in the small town of Liberty. It's perfect for business travelers, couples, Clemson parents, alumni, and small families. Tiled throughout for cleanliness. Privacy, tranquility, and clean, comfortable accommodations are what we provide. We are 10 minutes from Clemson and 3 miles from SWU. The Hideaway now offers Wi-Fi and Smart TV.

Guest favourite
Guest house in Greenville
4.87 out of 5 average rating, 15 reviews

Cozy Greenville Guest Suite w/ Fire Pit

Relax in this clean, comfortable guest suite featuring a cozy bedroom, bright kitchenette, and private bathroom. Start your day with a fresh cup of coffee or unwind by the fire pit, surrounded by peaceful woods and quiet nature views. This private space is perfect for solo travelers or couples looking for a calm, convenient Greenville stay with all the essentials.

Guest favourite
The studio features a spacious sleeping area with a large bed and a comfortable futon couch. A coffee table sits in front of the couch, and an electric fireplace is positioned nearby. A wall-mounted TV displays a serene image, while stylish lighting fixtures enhance the decor.
Guest house in Greenville
4.93 out of 5 average rating, 197 reviews

Gilded Frog Guesthouse. Rainfall Shower, King Bed

Welcome to the Gilded Frog Studio. Conveniently located between Greenville and Easley and only minutes from I85, we are positioned right in the heart of the growing Powdersville area. Whether you're visiting Greenville or looking for a local place to stay to catch a Clemson game, we offer the amenities you need to make your stay effortlessly enjoyable.

Guest house in Central
4.98 out of 5 average rating, 109 reviews

Breathtaking Romantic Rustic Style Loft - Clemson

Rustic styled 800 sq/ft full apartment above our barn-garage that sleeps 4. This amazing space is roomy and has separate parking and private entrance. Equipped with full kitchen, laundry, private deck and fire pit. We have adequate parking and pull thru drive for guests with boats. Pets are not permitted as some of our guests have allergies.

Top guest favourite
Large glass doors open to a serene outdoor space with natural stone pathways and grassy areas. Trees are visible in the background, and a seating area with wooden furniture is arranged on a patio. Soft natural light fills the room.
Guest house in Pendleton
5 out of 5 average rating, 36 reviews

Nested Studio Woodscape

Escape to our modern rustic and refined small studio apartment, nestled in the country. Tucked away in the trees, it sleeps four, with one bathroom. Experience the perfect blend of serene seclusion and contemporary comfort in this charming retreat. Ideal for nature lovers and close to nearby attractions. Book now for an unforgettable getaway!

Guest favourite
A spacious sleeping area is framed by sheer white curtains, creating a cozy retreat. The bedding is crisp and white, complemented by plump pillows arranged artfully. Soft lighting emits a gentle glow, enhancing the serene environment.
Guest house in Travelers Rest
4.78 out of 5 average rating, 23 reviews

The Rabbit Hole near the Swamp Rabbit Trail

Welcome to The Rabbit Hole. Escape to our serene retreat, ideal for families and furry friends alike! Nestled just 3 minutes from the scenic Swamp Rabbit Trail and a quick 6- minute drive to downtown Travelers Rest, our cozy haven is the perfect home-based for exploring the beautiful upstate region, including nearby Furman University.

Popular amenities for guest house rentals in Pickens County