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Holiday rentals in Santiago

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Top-rated holiday rentals in Santiago

Guests agree: these stays are highly rated for location, cleanliness and more.

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A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Flat in Los Canelos
4.8 out of 5 average rating, 40 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

An outdoor bathroom is enclosed by bamboo walls and natural stone, featuring a wooden basin and a unique circular shower area. Smooth pebbles create a textured border around the space, enhancing its connection to nature.
Cabin in Santa Fe
4.67 out of 5 average rating, 27 reviews

Treehouse

Come relax in this unique logging overlooking the Santa Maria's river. Immerse yourself in nature while having the comfort of quality beds and furniture. Ideal to spend a few nights when you are traveling or a long stay if you feel like reconnecting with what is essential. This beautiful habitat will rock you into the sounds and smells of Panama's mountain's soft nature. Outside kitchen and bathroom. Optional relax massage. Two queen size bed.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Flat in Santiago
5 out of 5 average rating, 4 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

A spacious living area is presented with a light-toned sofa adjacent to large windows, providing natural light. A metal shelving unit adorned with plants stands in the center, complemented by a simple round mirror on the wall. A wooden table and chair add functionality to the space.
Apartment in Santiago
4.67 out of 5 average rating, 15 reviews

Apartment 2A

Accessible apartment in the center of Santiago, located 300 meters from the Transportation terminal and walking distance to supermarkets and businesses. With good distribution of space, fresh and illuminated and with all basic amenities. The apartments provide a harmonious balance in the midst of the characteristic go and see of the center, perfect for stays of families, friends, professionals, couples.

Guest favourite
A tranquil garden scene is depicted, featuring a winding pathway of smooth stones and pebbles. Surrounding areas are adorned with various flowering plants and a small pond, enhancing the peaceful ambiance. Lush greenery is visible in the background, contributing to the serene atmosphere.
Farm stay in Santa Fe
4.9 out of 5 average rating, 297 reviews

Santa Fe villa with a espectacular view

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favourite
A welcoming living area features a comfortable leather sofa and a small dining table with two chairs. Natural light fills the space from sliding glass doors that open to a balcony, enhancing the connection with the outdoors. A kitchenette and a red refrigerator are visible in the corner.
Flat in Santiago
4.8 out of 5 average rating, 10 reviews

d'rosas apartamentos 5PA

Enjoy the simplicity of this quiet and central accommodation.Discover comfort in our cozy home in the heart of Santiago, Veraguas. Just a 5 minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring local culture and resting after a day of adventure. We look forward to seeing you!

Guest favourite
Flat in Santiago
4.83 out of 5 average rating, 6 reviews

Accommodation in Santiago Centro

Enjoy the easy access to everything from this perfectly located accommodation, in the center of Santiago 2 minutes from the cathedral church, park, and the central Ave. Fresh and comfortable on the ground floor of a property a large terrace with access to the patio surrounded by nature.

A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.
Home in Santiago
4.85 out of 5 average rating, 20 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

A modern one-story home with a flat roof features large windows framed by wooden slats. A well-manicured lawn surrounds the entrance, while a concrete pathway leads to the front door. The exterior is painted in neutral tones, contributing to its contemporary design.
Home in Santiago
4.78 out of 5 average rating, 112 reviews

3BD, 2BTHS, furnished house

House with 3 bedrooms, 2 bathrooms, central, furnished, security garage, kitchen, automatic washing machine, A/A, Wi-fi, cable TV, new construction in beautiful residential.

A softly lit bedroom features a spacious bed covered with a textured grey bedspread. Two pieces of wall art adorn the walls above the bed, with a bedside table holding a small plant. A full-length mirror supports the decor, complemented by light-grey curtains.
Flat in Santiago
4.67 out of 5 average rating, 9 reviews

Apartamento Señorial Urraca

Enjoy the simplicity of this quiet and central accommodation, ideal for you, with everything you need for a pleasant stay.

Guest favourite
A single-story house features an arched entry with decorative windows. The front porch is equipped with seating, surrounded by greenery. A paved driveway leads to the home, providing access for vehicles, while the roof offers ample shade.
Home in Santiago
4.9 out of 5 average rating, 10 reviews

Casa Nuevo San Juan

Easy access from the Panamericana. It is a central area has supermarket, pharmacy, restaurant, hospital availability.

Guest favourite
A dining area is shown with a dark wooden table and matching chairs. A bowl is placed at the center of the table. In the background, a modern kitchen is visible, featuring black cabinetry and stainless steel appliances, with a large window allowing natural light.
Home in Santiago
4.94 out of 5 average rating, 18 reviews

Santiago near Chicho Hospital. ULatinaTarifaxmes

Furnished house, equipped kitchen, amenities included, washer dryer, gardens with set of chairs for rest..

Popular amenities for Santiago holiday rentals

Quick stats about holiday rentals in Santiago

  • Total rentals

    60 properties

  • Nightly prices starting at

    ÂŁ7 before taxes and fees

  • Total number of reviews

    530 reviews

  • Family-friendly rentals

    20 properties are a good fit for families

  • Pet-friendly rentals

    20 properties allow pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  1. Airbnb
  2. Panama
  3. Veraguas Province
  4. Distrito Santiago
  5. Santiago