Holiday rentals in East Syracuse

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Top-rated holiday rentals in East Syracuse

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
A stainless steel refrigerator is positioned against a light-colored cabinet backdrop. The refrigerator features a water and ice dispenser on the front, and adjacent cabinets are complemented by a tiled backsplash with earthy tones.
Home in Syracuse
4.98 out of 5 average rating, 42 reviews

Welcome : Traveling Nurses / Family’s

Forget your worries in this spacious and cozy 3 bedroom, 2 bathroom home close to SU Free WiFi ,smart tv, living room and dining area master bedroom includes vanity area private bathroom all bedrooms comes with extra linen,Ironing board and iron available for use ,kitchen comes with small appliances dishes pots pans silverwar wine glasses. Nice quiet smoke free / pet free home. Proximity to Destiny mall nursing home hospital area, close to restaurants and shopping stores and family fun area

Top guest favourite
A single-story blue house is set against a lush green lawn. White steps lead to a welcoming porch with a railing. Potted plants are positioned near the entry, adding a touch of greenery. A tall lamp post stands on the right side of the yard.
Home in DeWitt
4.97 out of 5 average rating, 135 reviews

Anne's Place

Our place is conveniently located in a quiet and safe neighborhood just off the interstate - 10 minutes from Syracuse University, LeMoyne College, hospitals and downtown. It is just minutes away from Starbucks, Panera's, Wegmans and numerous other restaurants and shopping facilities. It is also very close to the Erie Canal trail (1/2 mile) for walking, jogging or biking. We have chosen to go with a farmhouse theme with our decor. We live next door and you will enjoy total privacy when you stay.

Superhost
Guest suite in Syracuse
4.84 out of 5 average rating, 108 reviews

Victorian Antique 1 Bdrm Ground Fl Apartment

1 Bedroom available 7min from downtown Syracuse. 3min from Destiny Mall, and Amtrak train/bus stations. This unit has an victorian style theme to it that showcases local art within the local area About 10 minutes from most areas of syracuse in every direction due to the central location and easy access to highways Keep in mind this is an inner city location it's safe but more of a working class neighborhood. There are security cameras around the property and off street parking in the back.

Guest favourite
A spacious backyard is depicted, featuring a wooden deck area with seating. Colorful chairs are arranged under string lights, casting a warm glow as night approaches. Pathways lined with stones and illuminated edges lead through a grassy area surrounded by decorative plants in pots.
Flat in Syracuse
4.95 out of 5 average rating, 141 reviews

SyracuseSpot-PoolTable/Traeger /Firepit /Cornhole

Do you want to spread out, BBQ, have a fire and other fun things to do? This is your SYRACUSE SPOT! The 1920's home (remodeled in 2025) is less than 10 minutes to most of the Syracuse venues, hospitals, and parks. Bring your family and friends (furry included) to our home and make it your own. Enjoy the fast Wi -Fi, full coffee/tea bar, snacks, and 4K TV's in every room! Our goal is to bring a high value option that provides a fun space unique to the market. We welcome you to CUSE!

Top guest favourite
A spacious living area features a comfortable gray sofa with decorative pillows, a stylish area rug, and a mounted television. Natural light enters through windows, while an open doorway leads to a bedroom with a bed framed by modern artwork. A dining table is set in the background.
Flat in DeWitt
4.98 out of 5 average rating, 58 reviews

Entire Modern Cozy 2BR Apt mins SU LeMoyne DT

Retro-inspired retreat with bold design, natural light, and a dedicated workspace—ideal for remote work or weekend stays. Conveniently located just minutes from key local destinations. Nearby Syracuse University & JMA Wireless Dome – ~2.5 miles / ~7 mins Le Moyne College – ~1.5 miles / ~5 mins Downtown -~3.4 miles / ~10 mins SUNY Upstate Medical University – ~3 miles / ~8 mins CNY Fertility Syracuse – ~3.4 miles / ~13 mins Syr Hancock Int'l Airport – ~4.2 miles / ~15 mins

Superhost
A cozy living area is presented, featuring a sectional sofa in warm tones. A round coffee table sits in front, accompanied by a modern desk and chair. Natural light filters through sheer curtains, highlighting a simple art piece on the wall and a small decorative vase.
Flat in Syracuse
4.93 out of 5 average rating, 105 reviews

Chic Comfort • Two Bedroom Apt

Relax in this bright, thoughtfully designed apartment featuring a cozy living area, stylish decor, and a dedicated workspace. Enjoy natural light and modern comfort. Minutes from downtown, Syracuse University, Destiny USA, and top hospitals. Features two bedrooms with comfy queen beds & a fully equipped kitchen. Perfect for business travelers, University visits, or weekend getaways. Just 12 minutes from the airport, with easy access to dining, shopping and entertainment.

Guest favourite
A spacious living area features a light, neutral palette complemented by wooden accents. Comfortable seating includes a sofa and two armchairs arranged around a glass coffee table. Natural light enters through the framed windows, while decorative plants add a touch of greenery.
Home in Syracuse
4.89 out of 5 average rating, 104 reviews

Charming Boho Getaway

Welcome to your private 1st-floor retreat on Syracuse's Westside! Just minutes from Syracuse University, Destiny USA, Tipp Hill, and downtown, this charming boho-inspired space offers handcrafted wood details, heated floors in the bathroom, and modern amenities. Whether your 'e here for business or leisure, you'll enjoy a comfortable and convenient stay with everything the city has to offer right at your doorstep. Perfect for exploring or relaxing in style!

Guest favourite
A living area features two expansive windows allowing natural light to fill the space. A comfortable sofa shares the room with a cozy armchair and a coffee table, accented by decorative items. An entertainment unit is positioned above a stylish fireplace, enhancing the modern decor.
Flat in Downtown Syracuse
4.94 out of 5 average rating, 54 reviews

Designer's retreat best location

Gorgeous designer studio in Montgomery House, a superbly renovated turn-of-the-century building. The flat is at the center of everything on downtown Syracuse's most picturesque treelined street. Everything is in its right place from the efficient kitchen to the spacious bath and gorgeous living and sleeping room. Designer furnishings, linens and original artwork come together to create a true oasis steps away from museums shops and restaurants.

Superhost
Home in Fayetteville
4.68 out of 5 average rating, 25 reviews

Charming Family Friendly Home | Central Location

Your family will be close to everything when you stay at this centrally-located place. Cozy 3 bedroom home in a quiet Fayetteville neighborhood — perfect for families! Sleeps 6 with 2 king beds, 1 queen, full kitchen, WiFi, smart TVs, washer/dryer, and grill. Movie theatre and children’s toys in the basement. Minutes to Green Lakes, Erie Canal Trail, and great dining. Clean, airy, and homey — ideal for relaxing or exploring the Syracuse area.

Top guest favourite
A spacious studio apartment features a wooden Murphy bed with a patterned coverlet, set against warm wood paneling. A small dining table with chairs is visible, along with a couch in a complementary color. A flat-screen television is mounted on the wall.
Guest suite in Syracuse
4.91 out of 5 average rating, 215 reviews

Affordable private basement apartment

My place is 10 min from Syracuse University, Upstate University hospital, Crouse Irving hospital, 5 min from LeMoyne College, 8 min from downtown Syracuse and St. Joeseph's Health hospital, 16 min from Green Lakes State Park... You’ll love my place because of the quaintness, the quiet and the proximity to what Syracuse has to offer. My place is good for couples, small families, solo adventurers, people with animals, and business travelers.

Guest favourite
Home in Syracuse
4.91 out of 5 average rating, 69 reviews

Syracuse Cozy Home Near SU & Destiny USA, Wi-Fi

Syracuse cozy, private, clean, and comfortable guesthouse in the Eastwood neighborhood. Ideally located just minutes from Syracuse University, downtown Syracuse, major hospitals, and top attractions. Enjoy fast WiFi, a fully equipped kitchen, free parking, self check-in, and complete privacy—perfect for business travelers, medical stays, families, and extended stays. A peaceful and convenient home away from home in Syracuse.

Guest favourite
A well-equipped kitchen is visible, featuring light wood cabinetry and granite countertops. Appliances include a refrigerator, oven, microwave, and dishwasher. A stacked washer and dryer are positioned nearby, along with a laundry basket. The flooring is a light wood, contributing to the spacious feel.
Flat in Syracuse
4.82 out of 5 average rating, 72 reviews

2 Bedroom Close to SU/ESF/Upstate. (F)

Enjoy easy access to everything from this centrally located place. Located directly on University Ave close to Hospitals, shopping, and many well-known Syracuse restaurants. Walking distance from ESF upstate, Syracuse University campus, Crouse and University Hospitals, and Marshal Square Mall!! This apartment is in a housing complex comprised mostly of graduate students.

Popular amenities for East Syracuse holiday rentals