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House holiday rentals in Isla Grande

Find and book unique houses on Airbnb

Top-rated house rentals in Isla Grande

Guests agree: these houses are highly rated for location, cleanliness and more.

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Guest favourite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira
4.97 out of 5 average rating, 114 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Superhost
Home in Isla Grande
5 out of 5 average rating, 4 reviews

BeachfrontHouse+Kitchen+Balcony+AC+WiFi@IslaGrande

✔️SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! 🚨Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones especiales 📍 Apartamento en Isla Grande, Provincia de Colon, Panamá 🇵🇦 🏡 Espacio limpio, cómodo y seguro, con excelente ubicación 🧼 Dotado con insumos y productos de limpieza Durante tu reserva, tu Airbnb cuenta con: 🌐Wifi 📺TV 🍳Cocina 🌊Frente al mar ❄️A/C 🚗Parqueo 👉Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones

Guest favourite
An open-concept loft is showcased with a high, sloped ceiling and large windows that invite natural light. Comfortable seating is arranged around a glass table, while a dining area and a cozy sleeping space can be seen in the background. Nature views are visible through the windows.
Home in Santa Rita Arriba
4.94 out of 5 average rating, 18 reviews

The Bird's Nest in the Clouds

Escape to the Clouds: A Nature Lover’s Retreat. Welcome to The Bird's Nest, a serene loft in Santa Rita Arriba, Colón, 50 minutes from the city. Perched in the mountains, this open-concept space offers breathtaking views, fresh breezes, and the sounds of nature - rain and birds. Sleep with doors open, no AC. Perfect for nature lovers, not for those needing silence or climate control. Pool with breathtaking view, wifi and modern comforts included. PLEASE READ ENTIRE DESCRIPTION BEFORE BOOKING.

Guest favourite
Serene waters reflect vibrant greens and blues, surrounded by lush vegetation. Two sailboats are anchored nearby a rustic hut, offering a glimpse of a tranquil lagoon. The distant hills cradle the scene, enhancing a connection with the natural landscape.
Home in Portobelo
5 out of 5 average rating, 15 reviews

AeolusGuestHouse Home in Portobelo National Park

Welcome to AeolusGuestHouse, a hidden retreat in Jose del Mar, inside the Portobelo National Park. Surrounded by protected jungle, mangroves, and calm lagoon. Ideal for disconnecting in nature. Kayaks are available, and boats pick you up at the dock in front of the house for local tours, including Venas Azules just 15 minutes away. The home offers 2 bedrooms, 4 beds, an equipped kitchen, AC, parking, and helpful hosts always ready to assist. Pure nature, zero crowds, unforgettable stays.

Superhost
Home in Mechi
4.63 out of 5 average rating, 8 reviews

Beachfront Home | En-Suites + Chef & Tours Avail

Wake up to the sound of the waves… More than a beachfront home, Zola Sol is a curated wellness and lifestyle experience, thoughtfully designed around you. Whether you’re looking to relax, reconnect, or celebrate, we can personalize your stay with experiences such as private chef, wellness services, juice offerings, boat tours, and more—all seamlessly arranged before or during your visit. Your Airbnb reservation is simply the first step in creating an unforgettable Zola Sol experience.

Top guest favourite
An outdoor terrace features a table with seating for four, framed by colorful chairs in red and blue. A hammock is suspended nearby, with the serene view of the water and distant hills providing a tranquil backdrop. Natural light illuminates the space, highlighting the coastal setting.
Home in Juan Gallego
4.93 out of 5 average rating, 89 reviews

Beachfront · Large Sea View · Family Friendly

Welcome to Kasa Leilani, a charming beach house nestled between the jungle and the reef in the heart of a natural park. With stunning views of the nearby Caribbean islands, this peaceful retreat offers the perfect blend of nature and comfort. Surrounded by abundant wildlife, you can relax, explore the reef, or discover the island and crystal-clear waters. Kasa Leilani provides a serene escape for nature lovers and beach enthusiasts alike, offering an unforgettable tropical getaway.

Guest favourite
Home in Colón
4.86 out of 5 average rating, 49 reviews

Family style living and close to the Panama Canal

As of OCT 2022 we double the Space for this house, see new photos. This house is located on reverted American areas transferred back to Panama, called Arco Iris, there’s plenty of space outside, the backyard can fit your family barbeque, the inside consist of an modern combination living room + kitchen, large bathroom and 2 bedrooms with closets, the place is air conditioned with large ceiling fans in each room and private parking. Pickup from the airport available for a fee

Guest favourite
Home in Maria Chiquita
4.89 out of 5 average rating, 37 reviews

Villa con Terraza Privada en Playa Escondida

**El apartamento** Planta Baja con terraza privada y la playa está a solo unos pasos ! Nuestra villa es una de las opciones más accesibles para familias con niños y adultos mayores !! >>>>podras llegar a la playa y a las piscinas sin preocuparte por subir escaleras ni usar elevadores <<<< *Amenidades del Resort* -Gimnasio -Kayak, botes de remo, Bohío con BBQ (reserva previa) -Restaurantes -Cancha de fútbol, pádel y volleyball -Parque acuático -Tiendita

Top guest favourite
Home in Maria Chiquita
4.96 out of 5 average rating, 53 reviews

“Hermosa y Cómoda Villa en Playa Escondida Resort”

Luxury Resorts y Villa, front lagoon view y playa solamente a 2min, Disfruta de una estadía cómoda y tranquila en este alojamiento totalmente equipado, ideal para matrimonios, familias, grupos pequeños o viajeros de negocios. Tiene capacidad para hasta 6 huéspedes, ofreciendo un ambiente acogedor, limpio y funcional,una terraza amplia,sin duda para una estancia agradable,

Superhost
An outdoor seating area is presented with four woven chairs positioned around a rectangular table. The view reveals a serene sea in the background, with a well-kept grassy area and scattered rocks leading to the water's edge. Bright sunlight enhances the peaceful atmosphere.
Home in La Guaira
4.69 out of 5 average rating, 183 reviews

Casa "El Terrenito" - Ocean Front

Amplia casa frente al mar con 2 habitaciones, una hab. con 3 camas queen y 2da con una king y una twin. Cocina, sala, comedor. Tiene todos los implementos para cocina, sabanas, estufa,nevera, A/C. Especial para relajarse!! Para fanáticos de la pesca podemos proporcionar una panga de pesca! Precio adicional por día y el capitán. Puede llevar mascota.

Superhost
Home in Palenque
4.75 out of 5 average rating, 8 reviews

Casa Palenque Panamá

Disfruta de una espectacular casa frente al mar, ideal para grupos y familias de hasta 14 personas. Relájate con vistas directas a la playa, amplios espacios interiores y exteriores, y todas las comodidades para una estancia inolvidable. Perfecta para descansar, convivir y crear recuerdos únicos con el sonido del mar como fondo. Somos pet friendly.

Superhost
An aerial view captures a serene bay bordered by lush tropical greenery. A small boat is anchored in the clear waters, and a spacious house is situated near the beach, surrounded by trees and open land, creating a harmonious natural setting.
Home in Playa Blanca
4.76 out of 5 average rating, 79 reviews

Sparrow's Point

Un lugar paradisiaco que muestra al caribe panameño en su mejor esplendor!! La playa de arena blanca protegida por una bahía de aguas cristalinas y enmarcada por la selva tropical crean un idílico contraste entre el verde del follaje y el azul de la laguna. Despierte a 10 pasos del mar.

Popular amenities for house rentals in Isla Grande

  1. Airbnb
  2. Panama
  3. Colón Province
  4. Isla Grande
  5. House rentals