
Holiday rentals in Isla Grande
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Isla Grande
Guests agree: these stays are highly rated for location, cleanliness and more.

Puntita Manzanillo, fantastic sea and jungle
Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

The Bird's Nest in the Clouds
Escape to the Clouds: A Nature Lover’s Retreat. Welcome to The Bird's Nest, a serene loft in Santa Rita Arriba, Colón, 50 minutes from the city. Perched in the mountains, this open-concept space offers breathtaking views, fresh breezes, and the sounds of nature - rain and birds. Sleep with doors open, no AC. Perfect for nature lovers, not for those needing silence or climate control. Pool with breathtaking view, wifi and modern comforts included. PLEASE READ ENTIRE DESCRIPTION BEFORE BOOKING.

Beachfront House in Isla Grande Province of Colon
Ven a relajarte en esta hermosa y acogedora casa frente al mar, situada en una isla mágica donde la gastronomía es exquisita con una gran variedad de mariscos y de sus playas encantadoras de aguas cristalinas y arena blanca. Hay una gran variedad de actividades por hacer y toda una cultura costera por conocer: Desde los bailes folclóricos (congo) hasta su hermoso pueblo de tez morena. No olvides preguntarnos de los toures turísticos disponibles a las islas cercanas, ¡No te arrepentirás!

Apartment in Playa Escondida Resort & Marina
Departamento completo en el mar Caribe con tres recamaras y dos baños , sala, comedor y una amplia terraza con bbq ubicado en Playa Escondida Resort & Marina frente al mar Caribe . Cuenta con Playa de arena blanca, piscinas, jacuzzis y bares/restaurantes, parque acuático . A hidden gem in the Caribbean coast of Panama: powdery-white sand and turquoise waters, mountains, lagoons, social areas, a marina, restaurants and stores. This paradise is less than 1 hour away from Panama City.

Bella Casa, Caribbean Sea, Juan Gallego (waterfront)
Hermosa Casa de Playa, frente al mar caribe, para descansar y relajarse al 100%. La Casa cuenta con una ubicación privilegiada, mantiene 4 habitaciones (una de ellas cuenta con una mampara para dividir de la sala y ampliar esa área en caso que se desee), sala, comedor, terraza privada, frente a Isla Grande. 4 habitaciones. 3 tienen TV con cable y una TV extra en la sala. Todas con con Aire Acondicionado. Cuenta con 2 baños completos. Cocina equipada y lista para disfrutar y Wifi

FACING THE SEA Cacique (Portobello Park)
A house! A real glass island in the heart of the jungle! In the middle of the Portobello National Park (access only by 4x4 AWD) nestled at the top of the hill, between sky/sea, away from all eyes, a transparent house where glass embraces nature on all sides creating a unique connection between the inside and the outside, ideal for resting, disconnecting, comfortable, spacious, cool (central air conditioning), exclusive. It is the witness of a grandiose spectacle that awaits you!

Pebos Reef Apt 2 · Beachfront · Sea View Terrace
This spectacular beachfront property is ideally situated with an incredible view of neighboring islands, fishing friendly waters, and mesmerizing snorkeling spots for children and adults to enjoy. Monkey greetings from the jungle adjacent, octopus and colorful native fish inhabited waters, and lazy bear sloth sightings are all part of your daily experiences here at Pebos Reef! If you are lucky you will even see dolphins from the terrace ! A terrace on the sea is all you need.

Entire Villa with pool in front of beach!
Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

Room at Finca Cacique- Jungle and Sea
Finca Cacique offers a true immersion in preserved tropical nature. This private 20 m² room with its own entrance is located just 350 meters from the village of Cacique. ⭐ Best part: you can forget your car. We’re close to the main attractions, and you can rent our kayaks to explore nearby islands like Isla Mamey and the famous Tunnel of Love. 🌿 Ideal for nature lovers seeking peace and adventure. (This is not a beachfront property, the beach is a 5-minute walk).

Apartment in Playa Escondida.
Recap Playa Escondida is a small 'paradise' an hour from the city. It is located in the Republic of Panama, in the coastal area of Costa Arriba in the Caribbean Sea. You can spend the day preparing your barbecue in a waterfront Bohío or if you prefer, savor the delights of the restaurants. And if you decide on physical activities, you will find soccer fields, volleyball, fishing or paddling, and it has water games for children that they will undoubtedly enjoy.

Playa Escondida Apartment with Ocean View
Luxurious 3 bedroom 3 bathroom apartment for 7 guests, fully furnished. Master Bedroom with a King Bed Bedroom 2 Queen Bed Bedroom 3 bunk bed (2 Twins) and a sofa bed Enjoy the ocean view from the comfort of your living room and feel like you're in paradise with our Bahamas-imported beach sand. It includes a floating children's park, paddle tennis court, soccer, volleyball, swimming pool, gym, restaurant, bar with home delivery, store, party room.

El Paraiso
We are pleased to present a large beautiful house for rent between the village of Cacique and the village of José Pobre in Portobelo National Park. Overlooking the Caribbean Sea, nestled in the jungle, this house has a unique character in the area. Its direct access to a small wild beach, with an exciting reef for snorkeling fans, makes it a privileged place. Ideal for groups and families wishing to reconnect with nature.
Popular amenities for Isla Grande holiday rentals
Other great holiday rentals in Isla Grande

NEW! Apt+AC+Pool+TV+Parking+BBQ at @MariaChiquita

Luxury Beachfront Escape | Chef & Tours Avail

La Casa Roja

Casa Chalis

Paradise in the Marina: Luxury Beach Condo

House facing Isla Grande

Cacique cabin-house

Beach House Ocean Front!
Destinations to explore
- Panama City Holiday rentals
- San Andrés Holiday rentals
- Puerto Viejo de Talamanca Holiday rentals
- Uvita Holiday rentals
- Boquete Holiday rentals
- Playa Blanca Holiday rentals
- Valle de Antón Holiday rentals
- Coveñas Holiday rentals
- Ancón Holiday rentals
- Bahía Ballena Holiday rentals
- Limon Holiday rentals
- Playa Venao Holiday rentals




