
Guest house holiday rentals in La Mesa
Find and book unique guest house rentals on Airbnb
Quick stats about guest house rentals in La Mesa

Total holiday rentals
Explore 90 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at £37 per night before taxes and fees

Verified guest reviews
Over 7,160 verified reviews to help you choose

Family-friendly holiday rentals
10 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 20 rentals that welcome pets

Holiday rentals with a pool
10 properties feature pools

Rentals with dedicated workspaces
50 properties have a dedicated workspace

Wifi availability
90 of La Mesa holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across La Mesa rentals

4.9 Average rating
La Mesa stays are highly rated by guests – averaging 4.9 out of 5!
Top-rated guest house rentals in La Mesa
Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

Private 1 BR Paradise Retreat
Private, yet central. It is your exclusive paradise retreat to enjoy from your spacious 1 bedroom guest house located on the lower level of our home. Hang out in the expansive and private backyard with pool, different sitting areas and covered BBQ room. Or maybe a workout in the gym. Centrally located in the Village of La mesa. Just a 1/4 mile jaunt into the quaint village with its numerous assortments of dining options, stores and trolley station. Freeway close to beaches, downtown and airport

Da Hui Hut - La Mesa’s best view and spa
Da Hui Hut is a very private oasis uniquely situated at the top of San Diego county's magnificent Mt. Helix. At roughly 1,300 feet above sea level, Mt. Helix is the crown jewel of natural landmarks in the area. The landscape provides bountiful views, and the large deck is positioned perfectly to see it all. It feels like you're on top of the city! Inside, guests will encounter Californian and Hawaiian inspired decor as they collide with wooden walls to compose a symphony of color and good vibes.

Anna's Historic Stone Cottage w/panoramic View!
Welcome to Anna's Historic Stone Cottage! The 110 year old cottage has been transformed into the perfect combination of romantic and rustic for a dream-worthy getaway. The 280sq ft cottage features stunning, panoramic views of the San Diego skyline while offering rooftop seating for sunrise and sunset viewing. The Cottage is conveniently located 20 minutes from the world famous San Diego zoo and most other must-see, tourist spots. Amenities for special occasions offered too. Check out our menu!

East Watch- a private getaway
East Watch is a 740 sq ft, 1 bedroom private retreat that provides the comforts and amenities of home with the style of a high-end hotel. All 5 to 15 min from shopping, downtown, and the beach. It's a short walk from Mt. Helix Park which offers a 360* view, weekday yoga, and stunning sunrises and sunsets. We have EV high speed car charging, a full kitchen with all appliances, workspace with dedicated fast WIFI, a spa shower, and super comfortable beds and pillows. Stay and let us charm you!

Vacation Paradise-Heated Pool+Hot Tub+FirePit+EV
Welcome to your personal resort! This is your private Guest House with a salt & heated pool + hot tub. Located in a very quiet & safe neighborhood in beautiful San Diego. Drive 15 minutes to the beach, downtown, La Jolla, Zoo, stadiums, Sea World, Convention Center + more. Hike next door at Cowell Mountain or Lake Murray. Smart TV, wifi, two zone AC, full kitchen, W/D combo, top quality finishes & furniture. Everything you need for memorable vacation! No smoking or vaping on the property.

Stunning Guest House 15 min. from Zoo, Downtown
Stunning guest house that's 15 minutes to San Diego Zoo + downtown San Diego. The cottage is decorated with mid-century and one-of-a kind furniture in a comfy living space overlooking a gorgeous garden. Enjoy the the garden on your private deck, watch TV while relaxing in the handcrafted Nicaraguan rocker or 1950s Danish slipper chair. The cottage also has a comfy queen-sized bed and a full kitchen that's stocked with what you'd need. Oh, and all guests arrive to a homemade loaf of bread.

Cozy Coop with a View
This house is perfect for a private get away. There is a patio bar & a large picture frame window that commands the best views in the area. Sit & enjoy the large patio right off the entryway to the house. I have been told our home used to be a chicken coop in the 50-60's. It is far different now, we just finished a complete remodel. Everything is updated, upgraded & ready for you. Being on the top of the hill you get the nice views, but sounds carries as well, please respect the neighbors.

Enchanting private Mt Helix retreat close to SDSU
This quiet retreat (5 min. from the quaint main street of downtown La Mesa) used to be a doll workshop. Drink your morning ritual on a private deck amongst the trees. 15 min. from downtown and SD airport. 10 minutes from SDSU. 25 minutes to La Jolla/ beaches and most San Diego colleges and attractions like Birch Aquarium. 15 minutes from Balboa Park museums. Hike Mission trails-15 min. from trailheads. Take a walk up scenic Mt Helix and enjoy the vistas. Flora and fauna abound.

Mountain top view getaway loft
This loft is completely sound proof! VIEWS, VIEWS, VIEWS!! Do not miss this stunning contemporary loft, located in the highly desired Mt. Helix community. The guest house faces west, giving you phenomenal 270-degree views of the ocean, Downtown, Point Loma, Coronado islands, Coronado bridge, and more! Designed and built by an acclaimed San Diego home designer, this property was featured in Dream Homes Magazine and is well known for its incredible design and construction.

La Cabana
Perfect getaway for the wandering individual, couple, or young family. This rustic casita is surrounded by beautiful mountain and ocean views! Enjoy swimming in the pool, stargazing, lounging, or casual day trips around San Diego (All the amenities are shared with the main house) . The casita has one king size bed and a memory foam sofa bed, with a well equipped kitchenette. Plenty of parking in driveway (max 2 cars). Please read entire listing for details.

Beautiful Bright Mt. Helix Studio
This beautiful newly remodeled studio is in the heart of Mt Helix, a unique community in San Diego close to freeways, shopping, dining and more. Mt. Helix is called the lungs of San Diego because of it's lush surroundings and unique lots. We are surrounded by citrus orchards and are on a mountain giving you beautifully fantastic views. We are located in a private and quiet community just minutes from everything SD is so famous for.

Private Studio with a Panoramic View
Escape to Your Hilltop Retreat! Relax in secluded studio. Sip wine by the cozy fire pit or unwind on the patio with a bird’s-eye view. Conveniently located just 15-20 minutes from the beach and downtown, you’re never far from the action. Bringing more friends or family along with you? We also have another listing, The Eagles Nest at the same property.
Popular amenities for guest house rentals in La Mesa
Family-friendly guest house rentals

The Happy Family * 2 playhouses near SDSU!

Fig Tree Bungalow

Spacious, private Mt. Helix country style studio

The Carriage House at Mt. Helix

SDCannaBnB #1 *420 *parking *dog-friendly *hot tub

Airstream•Sauna•SoakTub• Views•Firepit+Zoo add-on

Granny Flat with Bedroom/Bathroom/Kitchen

NEW construction - Studio by Village of La Mesa
Guest house rentals with a patio

Adorable 1- bedroom guesthouse/Casita

Beach views for 2! Jacuzzi, fire pit

AmazingVIEWS! Hilltop Guest House with XL Balcony~

SDSU Central Cozy Casita | Fast WiFi | Walkable

Guest house with ocean views and private deck.

Cozy Hillside Retreat with View

Loft Cabin•SoakTub•FirePit• Cinema•View+Zoo add-on

Cozy ADU in San Diego’s suburban rural mix area.
Guest house rentals with a washing machine and dryer

Santorini-Inspired Cottage w/ Hot Tub + Views

Charming Mission Hills Studio w/ Patio
*BEAUTIFUL* Sunny Home in Golden Hill

Modern mountain guest house. Incredible views

Fletcher Hills - modern 1 BR.Easy, no step access.

Indoor/Outdoor Sanctuary in Ocean Beach

Trendy 1 BR Guesthouse. Great views, no chores.

Mt Helix Studio Loft with Mountain Views
When is the best time to visit La Mesa?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | £87 | £87 | £89 | £87 | £97 | £101 | £106 | £94 | £87 | £90 | £90 | £86 |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
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- Rentals with an EV charger La Mesa
- Rentals with a hot tub La Mesa
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- Family-friendly rentals La Mesa
- Smoking-friendly rentals La Mesa
- Pet-friendly rentals La Mesa
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- Rentals with a firepit La Mesa
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- Rentals with a patio La Mesa
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- Rentals with a washing machine and dryer La Mesa
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- Guest house rentals San Diego County
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- SeaWorld San Diego
- Rosarito Beach
- Coronado Beach
- University of California-San Diego
- LEGOLAND California
- San Diego Zoo Safari Park
- San Diego Zoo
- Petco Park
- San Diego Convention Center E Ent
- Pacific Beach
- Balboa Park
- Tijuana Beach
- Pechanga Resort Casino
- San Diego State University
- Torrey Pines State Beach
- Oceanside City Beach
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- Las Olas Resort & Spa
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