
Guest house holiday rentals in La Mesa
Find and book unique guest house rentals on Airbnb
Top-rated guest house rentals in La Mesa
Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

Private 1 BR Paradise retreat
Private, yet central. It is your exclusive paradise retreat to enjoy from your spacious 1 bedroom guest house located on the lower level of our home. Hang out in the expansive and private backyard with pool, different sitting areas and covered BBQ room. Or maybe a workout in the gym. Centrally located in the Village of La mesa. Just a 1/4 mile jaunt into the quaint village with its numerous assortments of dining options, stores and trolley station. Freeway close to beaches, downtown and airport

Da Hui Hut - La Mesa’s best view and spa
Da Hui Hut is a very private oasis uniquely situated at the top of San Diego county's magnificent Mt. Helix. At roughly 1,300 feet above sea level, Mt. Helix is the crown jewel of natural landmarks in the area. The landscape provides bountiful views, and the large deck is positioned perfectly to see it all. It feels like you're on top of the city! Inside, guests will encounter Californian and Hawaiian inspired decor as they collide with wooden walls to compose a symphony of color and good vibes.

NEW construction - Studio near the Village
New studio - Attached Dwelling Unit (ADU) with a private entrance. Walking distance to the Village of La Mesa which has several restaurants, shops and a Vons. Very close to SDSU and quick access to multiple freeways that take you to beaches, mountains, SD Zoo, the nightlife in downtown SD (8, 94, 125). Access to shared laundry room, 2 parking spaces and its own outdoor area. AC & heat. WiFi. Netflix, Hulu with live TV, Apple TV, Disney +, Prime Video and HBO Max. Crib and high chair upon request

Central & Serene Secret Garden Guesthouse
My cozy & stylish Garden Guesthouse features colorful decor that gives a fun, relaxed vibe. Relax in style inside or outside in my peaceful garden w a cup of coffee, or glass of wine. I love to say a hi to my guests yet your privacy is #1. Reach me via Airbnb app if I can help! Kensington is a central, 1920’s historic neighborhood w shops & great local eateries. Close to downtown, Gaslamp, Zoo, airport, beaches, Balboa Park. Bus stop, & trolley nearby. Reserved off street parking space too!

Anna's Historic Stone Cottage w/panoramic View!
Welcome to Anna's Historic Stone Cottage! The 110 year old cottage has been transformed into the perfect combination of romantic and rustic for a dream-worthy getaway. The 280sq ft cottage features stunning, panoramic views of the San Diego skyline while offering rooftop seating for sunrise and sunset viewing. The Cottage is conveniently located 20 minutes from the world famous San Diego zoo and most other must-see, tourist spots. Amenities for special occasions offered too. Check out our menu!

Stunning Guest House 15 min. from Zoo, Downtown
Stunning guest house that's 15 minutes to San Diego Zoo + downtown San Diego. The cottage is decorated with mid-century and one-of-a kind furniture in a comfy living space overlooking a gorgeous garden. Enjoy the the garden on your private deck, watch TV while relaxing in the handcrafted Nicaraguan rocker or 1950s Danish slipper chair. The cottage also has a comfy queen-sized bed and a full kitchen that's stocked with what you'd need. Oh, and all guests arrive to a homemade loaf of bread.

Cozy Coop with a View
This house is perfect for a private get away. There is a patio bar & a large picture frame window that commands the best views in the area. Sit & enjoy the large patio right off the entryway to the house. I have been told our home used to be a chicken coop in the 50-60's. It is far different now, we just finished a complete remodel. Everything is updated, upgraded & ready for you. Being on the top of the hill you get the nice views, but sounds carries as well, please respect the neighbors.

SDCannaBnB #1 *420 *parking *dog-friendly *hot tub
Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our casita is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our casita has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our casita is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Hilltop Casita Mount Helix
View the sunrise and sunset from this panoramic hilltop casita. Enjoy a charming getaway with sweeping views of the mountains and valleys. Enjoy refreshments on private patio while taking in the sights of palm trees and endless hills. Located 15 miles from the beach and 20 minutes from many major San Diego attractions. Please note: we currently have an outdoor renovation project in process behind the casita. There may be days during your stay in which outdoor work is being performed.

Private Detached Modern Studio located in La Mesa
**Cleaned and disinfected following COVID-19 guidelines provided by CDC/Airbnb** Modern studio with private entry, walking distance from stores, shops, restaurants, and parks. Cozy for a couple and sleeps up to 5. Feel at home with your own private laundry, full size kitchen, and private bath. 3 minutes from Highways 125, 94, and 8. Centrally located and less than 15 minutes from downtown San Diego.

Private Studio with a Panoramic View
Escape to Your Hilltop Retreat! Relax in secluded studio. Sip wine by the cozy fire pit or unwind on the patio with a bird’s-eye view. Conveniently located just 15-20 minutes from the beach and downtown, you’re never far from the action. Plus, well-behaved pets are always welcome. Bringing more friends or family along with you? We also have another listing, The Eagles Nest at the same property.

Spacious, private Mt. Helix country style studio
Located in a quiet and lush neighborhood, in hills of La Mesa. This private studio has everything you need to relax and experience the California life: comfy queen size bed, full kitchen, patio, bbq, and fire pit. Within walking distance to Mt. Helix Historic Park for a spectacular 365-degree view of San Diego. You are 20 minutes from the beach, airport, and mountains.
Popular amenities for guest house rentals in La Mesa
Family-friendly guest house rentals

Insta-worthy! 1 night/many nights, no min required

"Glam Farmhouse dream cottage"🏠🌠

The Happy Family * 2 playhouses near SDSU!

Adorable cottage in Talmadge

Views! Outdoor Cinema•SoakTub +Zoo add-on

Private Garden Studio

The Carriage House at Mt. Helix

Views•Sauna•SoakTub•Firepit+Zoo add-on
Guest house rentals with a patio

Adorable 1- bedroom guesthouse/Casita

Private Guesthouse ADU #1 · Mira Mesa · Kit & Bath

Free Bikes. 5 min walk to Windensea Beach La Jolla

La Jolla Oasis: Ocean, City and Fire Works Views

SDSU Central Cozy Casita | Fast Wi-Fi | Walkable

*KING BED* Colorful Guesthouse by Downtown

San Diego Newly Built Private Guesthouse (Sleep 4)

Central studio w/ private outdoor space & parking
Guest house rentals with a washing machine and dryer

Lovely Guesthouse in garden setting

Relaxing Oasis - short walk to shops & recreation

Hidden Casita with Private Deck & Patio

South Mission Beach Zen-Like Studio

Modern mountain guest house. Incredible views

BEAUTIFUL Private Studio

New Guest House - North Park

Clean Cozy Private Guesthouse | Central San Diego
When is the best time to visit La Mesa?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | £92 | £92 | £90 | £87 | £97 | £101 | £106 | £94 | £87 | £90 | £92 | £88 |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Quick stats about guest house rentals in La Mesa

Total holiday rentals
Explore 90 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at £37 per night before taxes and fees

Verified guest reviews
Over 6,510 verified reviews to help you choose

Pet-friendly holiday rentals
Find 10 rentals that welcome pets

Rentals with dedicated workspaces
50 properties have a dedicated workspace

Wifi availability
90 of La Mesa holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across La Mesa rentals

4.9 Average rating
La Mesa stays are highly rated by guests – averaging 4.9 out of 5!
Destinations to explore
- Southern California Holiday rentals
- Los Angeles Holiday rentals
- Stanton Holiday rentals
- Channel Islands of California Holiday rentals
- Las Vegas Holiday rentals
- San Diego Holiday rentals
- Phoenix Holiday rentals
- Palm Springs Holiday rentals
- San Fernando Valley Holiday rentals
- Scottsdale Holiday rentals
- Henderson Holiday rentals
- Big Bear Lake Holiday rentals
- Pet-friendly rentals La Mesa
- Fitness-friendly rentals La Mesa
- Flat rentals La Mesa
- Rentals with a washing machine and dryer La Mesa
- Family-friendly rentals La Mesa
- Smoking-friendly rentals La Mesa
- Rentals with a fireplace La Mesa
- Rentals with breakfast La Mesa
- Rentals with a patio La Mesa
- Rentals with an EV charger La Mesa
- House rentals La Mesa
- Private suite rentals La Mesa
- Rentals with a firepit La Mesa
- Rentals with outdoor seating La Mesa
- Rentals with a beach view La Mesa
- Villa rentals La Mesa
- Rentals with beach access La Mesa
- Rentals with pools La Mesa
- Rentals with a hot tub La Mesa
- Guest house rentals San Diego County
- Guest house rentals California
- Guest house rentals United States
- Rosarito Beach
- Oceanside City Beach
- LEGOLAND California
- SeaWorld San Diego
- Torrey Pines State Beach
- Tijuana Beach
- University of California-San Diego
- San Diego Zoo Safari Park
- Pacific Beach
- Balboa Park
- Pechanga Resort Casino
- La Misión Beach
- Moonlight State Beach
- Liberty Station
- Oceanside Harbor
- Belmont Park
- Coronado Shores Beach
- Sesame Place San Diego
- Black's Beach
- Law Street Beach
- Torrey Pines Golf Course
- USS Midway Museum
- Mission Beach
- La Jolla Cove




