
Hotel holiday rentals in Mission Bay
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Top-rated hotel rentals in Mission Bay
Guests agree: these hotel rentals are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for hotel rentals in Mission Bay
Family-friendly hotel rentals

Stylish San Diego downtown Suite

Ocean Beach - Bed in a 8-Bed Mixed Dorm

Ensuite Private Room at Stylish Hostel

Coliving Gaslamp Quarter Dorm Bed

Pet-friendly Hotel with Free Breakfast and Pool!

At the heart of Gaslamp District

Greely Gaslamp - Loft w Parking & 3 Beds #302

Ocean Beach - Bed in 6-Bed Mixed Room
Hotel rentals with a pool

Recently reno’d escape near the Gaslamp Quarter

Convenient Base Near San Diego Zoo & Balboa Park

Wyndham Bayside | Premium King | Free Shuttle

Iconic Resort in San Diego

2 Pet-friendly Rooms—Minutes to Mission Bay Beach

Playful escape near games & concerts at Petco Park

1-Bedroom Hotel Suite - 2 beds

Downtown Delight: Pets Allowed, Parking, Pool!
Hotel rentals with a patio

Modern King Room | Luxe Stay in Little Italy

WorldMark Inn at the Park

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

San Diego 2 Queen Suite City View w/ Breakfast

Charming 1 bedroom resort steps away from beach

Comic-Con 2026: Spacious King Suite + Sofa Bed

ITH Mission Beach Backpacker Hostel Mixed Dorm
Destinations to explore
- Southern California Holiday rentals
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- Channel Islands of California Holiday rentals
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- Palm Springs Holiday rentals
- San Fernando Valley Holiday rentals
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- Anaheim Holiday rentals
- Rentals with an EV charger Mission Bay
- Rentals with a beach view Mission Bay
- Townhouse rentals Mission Bay
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- Pet-friendly rentals Mission Bay
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- Waterfront rentals Mission Bay
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- Rentals with a washing machine and dryer Mission Bay
- Rentals with a firepit Mission Bay
- Rentals with outdoor seating Mission Bay
- Rentals with pools Mission Bay
- Flat rentals Mission Bay
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- Rentals with a patio Mission Bay
- House rentals Mission Bay
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- Rentals with a sauna Mission Bay
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- Balboa Park
- Windansea Beach
- Santa Monica Beach
- Playas Los Buenos
- Playa Popotla
- San Onofre State Beach
- Morgan Run Club & Resort
- University of California San Diego
- Silver Strand State Beach
- Liberty Station
- Cardiff State Beach
- Torrey Pines Gliderport
- Citizens Trail
- Mission Trails Regional Park
- St Malo Beach
- South Oceanside Beach
- Strand Beach
- Buccaneer Beach
- Oceanside Harbor Beach
- Gladiator Beach
- Trails State Beach
- Riviera
- T-Street Beach
- San Clemente City Beach