
House holiday rentals in Rochester
Find and book unique houses on Airbnb
Top-rated house rentals in Rochester
Guests agree: these houses are highly rated for location, cleanliness and more.

Cottage in Lowertown–Perfect for Mayo & Downtown
In Lowertown-this quaint cottage with modern updates is your home away from home! Fully furnished and a well stocked kitchen make it a wonderful place for overnight stays or longer term rentals. Beautiful patio provides an urban sanctuary at the end of a long day. Close proximity to Mayo Clinic-downtown restaurants, grocery stores and shopping are within walking distance. Two blocks in either direction puts you on the trail system. Public transit 1 ½ blocks away and a laundromat is ½ block away.

Euro House, Bright! Near Mayo-Single Family Home
Welcome to your home away from home! This private, single-family home was thoughtfully designed and is located in a quiet area just 5 minutes (0.9 miles) from the Mayo Clinic. Step into a master gardener’s dream—a beautifully landscaped yard filled with native plants and outdoor seating, perfect for relaxing after a long day. 2 Queen Bedrooms, 2 Full Bathrooms, modern finishes throughout, Super clean and pet-free. Off-street parking, Washer & dryer, Wi-Fi, Smart TVs & Fully stocked kitchen.

The Little House | 1 mi from downtown, Love Pets!
The Little House is the perfect place of you're looking for something Cozy, stylish, and close to everything that you need. This home was a fun renovation project for my husband and I. It's located in the family friendly Sunnyside Addition neighborhood and we've worked hard to make sure you have everything you need during your stay. This home has a beautiful fully fenced in yard with a neighborhood feel while still being less than a 5 minute drive from Downtown & Mayo Clinic Campuses!

Mayo Downtown's Prairie Home Retreat
Nestled in a serene corner, this home offers a perfect blend of tranquility and accessibility; being near the Mayo campus and Rochester's key attractions. Enjoy comfortable beds, a well-appointed kitchen, and a fenced yard with patio gardens. It's an excellent spot for family bonding, featuring three smart TVs, rapid Wi-Fi, and a variety of indoor and outdoor entertainment options. We strive to accommodate flexible check-in/check-out arrangements whenever feasible. Rollator accessible.

Oasis - Comfort & Serenity (Full house near Mayo)
*Discount for extended stays* Seeking a peaceful respite near Mayo Clinic in Rochester, MN? Look no further than "Oasis"–your ultimate home away from home. We offer 5 beds, 2 baths, & can accommodate up to 8 guests. Recharge in the workout & yoga meditation room, stay connected in the office area, & explore Rochester's attractions. Your dedicated host Peggy, a Mayo employee, will ensure a seamless/enjoyable stay. Book now & experience the perfect blend of comfort & serenity at Oasis.

Peaceful Stay by Silver Lake, Fireplace, KingBed
Beautiful house with 4 bedrooms, 2 bathrooms in the peaceful neighborhood of Silver Lake. 2 miles from Mayo Clinic. 3 bedrooms on main floor, fully equipped modern kitchen; spacious family rooms on each floor; washer and dryer on site; attached two car garage; fenced yard to provide privacy and serenity. Convenient access to shopping centers and restaurants. near bus stop; two minutes walk to silver lake with benches, picnic area and walking path. Complementary fast speed internet

Spacious Modern Home Near Mayo, St. Mary's Campus
- 5 min walk to Mayo Clinic, St. Mary’s campus - 3 bedrooms, 3 bathrooms, and a loft - unique design with vaulted ceiling and skylights in the style of Frank Lloyd Wright, one of its kind in the whole neighborhood - two-car garage + another dedicated parking space outside - walkable and safe family-friendly neighborhood close to downtown and all amenities - outside front and back patios - fusball play table - dedicated workspace - high speed wifi - Apple TVs - washer and dryer

Entire Boutique Home Kutzky Park ★ Walk to Mayo ★
Welcome to Asfar house! Expertly designed and centrally-located in a desirable Kutzky Park neighborhood, walking distance to Mayo Clinic, restaurants and shops. Whether you are relocating or visiting Rochester, this house will be sure to impress. Blasting fast WIFI, 3 relaxing bedrooms & a fully equipped kitchen. A perfect retreat to enjoy the coffee bar, read, watch a Netflix episode, play and relax. Enjoy the perfect shower, conveniently adjoined with free washer and dryer.

Entire Spacious House, 1/2 block from St. Marys
Older charming home! Less than one block from St. Mary's hospital. Ideal space for clinic patients and their families. Entire residential home with on-site parking for up to 3 cars. Located in the heart of Rochester Minnesota, within walking distance to Mayo Clinic and many necessities such as grocery stores, coffee shops, mayo shuttles, and restaurants. This location is a perfect home away from home, fully stocked kitchen, comfortable beds, and lots of room to spread out!

The Guesthouse Cottage, walkable to Mayo Clinic
Our Guesthouse has a clean cottage feel. The king and queen bedrooms offer closets and quality linens. Cook meals in a fully stocked kitchen. Book an Uber, or walk 0.6 miles to Mayo's main Gonda building. We're close to grocers, coffee, parks and trails, and downtown's restaurants, shops, and a lovely public library. Free washer and dryer on site. Google TV and internet. 3-season porch. Small guest garage. No smoking on the property.

The Sierra! Close to Mayo Clinic
Gorgeous Home close to Mayo Clinic. The family room and living include Roku 4K UHD TVs, Foosball, and darts. Free WIFI. Office on Main with great light. Beautiful front porch or patio in the rear. TVs Enjoy luxurious finishes like crown molding, a fireplace in the family room, quartz countertops and a stunning vaulted Primary Ensuite with custom tile work and paneled doors. All of this is conveniently just minutes from downtown!

Cozy home next to Mayo Clinic & historic parks!
Cozy single level 2 bedroom, 1 bath. Fully furnished kitchen with TV, WiFi, and smart lock. It’s a 1.6 miles to Mayo Clinic. Walking distance to Historic Quarry Hill Park and Silver Lake Park. City bus line to Mayo Clinic 1/2 block away. Newly remodeled bathroom with full linen and toiletries. Quiet neighborhood, with full driveway parking. We also have a baby gate for the stairs. Enjoy your next home away from home !
Popular amenities for house rentals in Rochester
House rentals with a pool

4bd/2.5bth Single-Family Home Close to Mayo

4bd/2.5bth Single-Family Home Close to Mayo

Unit 2377J | 3bd/2bth | Single-Family Home

RARE! Pool, hot tub, garden &chickens! 4m to Mayo

Unit 2365J | 2bd/2bth | Single-Family Home
Weekly house rentals

The Little Blue Inn

Come From Away!

2.5 miles to Mayo, 4 step entry Covered By Faith

Apple Hill guest house close to Mayo Clinic

The Cozy Hope House -- Minutes from Mayo Clinic

Cascade Lake Park Home

Charming 2BR/2BA Near Mayo with Backyard Oasis

Medcity Manor
Private house rentals

Home in Rochester-Mayo Clinic

The Cozy Blue Haven: 1 mi to Mayo

3BR House Close to Mayo Clinic

Oasis by the Mayo Clinic

House in the trees with City View (Haakon House)

Quarry Hill Home

Zumbro Lake Home

Relax & Recharge-3BR w/garage 3 blocks To Mayo!
When is the best time to visit Rochester?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | £76 | £72 | £74 | £76 | £83 | £86 | £89 | £85 | £82 | £82 | £82 | £82 |
| Avg. temp | -10°C | -7°C | 0°C | 7°C | 14°C | 20°C | 21°C | 20°C | 16°C | 9°C | 1°C | -6°C |
Quick stats about house rentals in Rochester

Total holiday rentals
Explore 430 holiday rentals in Rochester

Nightly prices starting at
Rochester holiday rentals start at £15 per night before taxes and fees

Verified guest reviews
Over 22,520 verified reviews to help you choose

Family-friendly holiday rentals
320 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 120 rentals that welcome pets

Rentals with dedicated workspaces
290 properties have a dedicated workspace

Wifi availability
430 of Rochester holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Rochester rentals

4.9 Average rating
Rochester stays are highly rated by guests – averaging 4.9 out of 5!
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