Some info has been automatically translated. Show original language

Holiday rentals in Los Santos Province

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Los Santos Province

Guests agree: these stays are highly rated for location, cleanliness and more.

%{current} / %{total}1 / 1
Superhost
Cottage in Playa El Jobo
4.76 out of 5 average rating, 120 reviews

Disfruta una Casa de Playa frente al mar, patio

Playa El Jobo is a magical place, special for connecting with nature and resting. It is oceanfront at a height of 9 meters, which allows you to receive the cool sea breeze. The property has a wooden house with a first floor and an upper floor. On the ground floor you will find the kitchen, two full bathrooms, two outdoor showers and a covered space with hammocks. Upstairs there is a large balcony with hammocks, two bedrooms, a living area and two bathrooms. There is good lighting, natural ventilation and A/C

Superhost
An aerial view of a modern, three-bedroom villa nestled among dense green foliage. The structure features a light-colored exterior with a metal roof. A pool area is visible at the back, framed by lush trees, creating a sense of privacy and connection to nature.
Villa in Las Escobas del Venado
4.86 out of 5 average rating, 7 reviews

El Nido, Jungle Villa with Pool at Venao

Escape to El Nido, a stunning 3-bedroom, 3-bathroom jungle villa offering the perfect blend of tranquility and modern comfort. Nestled in Playa Venao, Panama, this boho-chic home features vibrant interiors, breathtaking ocean views, and a private pool. Ideal for families, groups, or remote workers, El Nido is just 2 minutes from the beach and Venao’s lively center, where you’ll find top dining, activities, and local charm. With high-speed Wi-Fi, a fully equipped kitchen, and spacious living area

Guest favourite
A charming beach house is surrounded by lush greenery and palm trees, elevated on sturdy pillars. The thatched roof complements the tropical setting, while large windows provide ample natural light. A spacious wooden deck with railing enhances the inviting outdoor space.
Home in Cambutal
4.9 out of 5 average rating, 31 reviews

Seaside Sanctuary • Steps to Surf • Fast Internet

Wake up to the rhythmic sounds of waves steps from your bed in this intimate beachfront paradise. Our charming one-bedroom home sits directly on Cambutal's pristine shoreline, offering ocean views and instant beach access. Relax on your private terrace with morning coffee as the sun rises, cook meals in the fully-equipped kitchen, and fall asleep to the soothing sounds of the surf. With Starlink internet, you can stay connected while experiencing the perfect blend of seclusion and convenience.

Top guest favourite
The rustic wooden cabaña is nestled among trees, featuring a sloped roof and a cozy porch illuminated by warm lights. A vibrant hammock is draped beneath the porch, surrounded by lush greenery and a gravel path, showcasing a tranquil outdoor atmosphere.
Cabin in Cambutal
4.94 out of 5 average rating, 70 reviews

Charming Cabaña on the beach

If you're looking for a place to relax and experience the magic of Cambutal with its lush jungle and stunning beaches, look no further. Nestled amongst the trees and overlooking one of the best swimming bays around, this rustic wooden cabaña has everything you need to make your stay unforgettable. Wake up to the sounds of the ocean on your doorstep, spend your days swimming in the warm ocean, or try other exciting activities, such as horse riding, hiking, yoga, surfing, diving and snorkelling.

Guest favourite
A spacious living area features a comfortable sofa adorned with various striped and patterned cushions. A round wooden coffee table displays neatly stacked books and candles. The modern kitchen is partially visible, showcasing sleek cabinetry and a smooth countertop.
Flat in Las Escobas del Venado
4.98 out of 5 average rating, 122 reviews

LUXURY Apartment in BLUE Playa Venao D-32

Brand new 2 bedrooms luxury apartment, fully equipment, well organized for families, friends or even just for you. All you need for the perfect relaxed vacation, just bring your clothes and good energy and we will take care for the rest. Located in the best location, in the middle of everything (but still very quiet). A very short walking to the beach (with direct access), restaurants, bars, shops, supermarket, surfing schools, Yoga & wellness centers, horses riding, ATM and a gas station.

Superhost
A wooden decoration is positioned on the bedspread, showcasing the words 'With Love Made in Panama.' The bed features a wooden headboard, complemented by a bedside lamp. Soft blankets and neutral-colored walls create a cozy sleeping environment.
Holiday home in Chitre
4.89 out of 5 average rating, 75 reviews

CASA EdditA ° Cozy house in Chitré

° CASA EDDITA ° Fully equipped house for your enjoyment. Spacious, cool, and cozy in one of the best-located residential areas of Chitré, close to everything: supermarkets, casinos, and a bus terminal. If you are thinking of touring Azuero, we suggest you stop at Casa Eddita, visit downtown Chitré, its handicrafts, cathedral and its variety of typical foods; from here you will be only 1:30 hr from the best beaches of Azuero in Pedasí (Playa Venao and Isla Iguana) Welcome!

Superhost
A sunset view from the property captures golden rays casting soft light over lush greenery and distant hills. The vibrant hues of the sky blend into warm oranges and yellows, illuminating the surroundings, while the ocean can be faintly seen in the distance.
Cottage in Cañas
4.88 out of 5 average rating, 8 reviews

Bella Vista wooden house - near Playa Venao

Unique house in Los Santos! This home is a 60 years old Panamanian wooden house that's been renovated while still keeping its charm. 2 bedroom (main bedroom with king size bed, 2nd bedroom with twin size bed), 1 bathroom, fully equipped kitchen with spacious living and dining room. 1 closed and secure office with A/C with all the equipment needed (office chair, monitor, keypad...) A/C only in office, rest of house with fans! Papaya, our cat, lives in the house!

Superhost
A colorful hammock hangs between two posts on a wooden terrace, overlooking a vast landscape. The sun sets in the distance, casting a warm glow over the scene, framed by lush greenery and bamboo fencing that adds privacy.
Home in Provincia de Los Santos
4.93 out of 5 average rating, 14 reviews

Casa Inito - Romantic Getaway

Indulge in the charm of Casa Inito, a thoughtfully crafted haven that invites you to experience a one-bedroom retreat like no other. This well-designed space seamlessly blends modern comfort with an intimate setting, creating the perfect atmosphere for your getaway. The Villa is located just 7 minutes from Playa Venao Beach (by car). ****(Vehicle a MUST, preferably SUV due to steep paved access road)****

Guest favourite
A spacious sleeping area features a large bed with a white comforter, flanked by two woven pendant lights. Natural wood accents are present in the furniture, including a slatted wooden ceiling and a wall-mounted television, with large windows allowing ample natural light.
Cabin in Playa Venao
4.92 out of 5 average rating, 52 reviews

Dos Mares Venao Village - Cabin

Desconecta de tu rutina y disfruta de la naturaleza. Nuestras Cabañas son amplias, cómodas, con mucho estilo y de alta calidad. La cama king invita a descansar. Además tenemos doble lavado, televisión, ducha y baño separado y una terraza amplia. En nuestro bar puedes disfrutar de los mejores desayunos. Si deseas también te lo llevamos directo a tu cabaña - como lo deseas!

Top guest favourite
Cabin in Playa Guánico Abajo
4.95 out of 5 average rating, 38 reviews

Guanico Beach Cabin

Cuarto ideal para dos personas a unos pasos de la playa Guanico. Relájate en este espacio tranquilo y luminoso. Cuarto con cama doble, aire acondicionado y abanico de techo. Disponen de una terraza con sillas y hamacas. Bloque sanitario exterior con ducha y baño privado. Mini refrigeradora en el cuarto Wifi disponible y illimitado 🛜

Top guest favourite
The exterior of a modern casita is visible, featuring a combination of wood and dark siding. Large glass windows provide unobstructed views of the surroundings. A shaded outdoor seating area is present, surrounded by lush green plants, creating a welcoming entrance.
Tiny home in Playa Los Destiladeros
4.94 out of 5 average rating, 78 reviews

Brisa del Mar Cottage

Casita Brisa del Mar ~ Welcome to this special space which we have poured our hearts, souls, hopes and dreams into creating. 2 minute walk from one of the most beautiful beaches in Panama. Pacific Ocean views from every room (except the bathroom). We are also a drive away from limitless adventures on the Azuero Peninsula.

Guest favourite
A bright bedroom is displayed, featuring a spacious bed covered with a textured white blanket. A television is mounted on the wall opposite the bed. Natural light floods through large windows, accompanied by sheer curtains. A cozy orange chair and potted plant add a touch of warmth.
Tiny home in Playa El Jobo
4.95 out of 5 average rating, 38 reviews

Private Beach Studio · Sunset & Nature Views

10 min drive- Las Tablas Get away from it all when you stay under the stars. A room very close to the sea, with an open kitchen that will allow you to disconnect and enjoy the view and nature in Las Tablas. You can plan to visit nearby beaches or take a walk through Pedasí, 30 minutes from Las Tablas.

Popular amenities for Los Santos Province holiday rentals