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Holiday rentals in Santa Cruz

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Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guest house in El Valle de Antón
4.99 out of 5 average rating, 119 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Top guest favourite
Home in Costa Esmeralda
4.98 out of 5 average rating, 207 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Guest favourite
A private pool area is featured, surrounded by lush greenery. A patio table with six chairs invites dining outdoors, while a lounge chair with colorful stripes offers a spot for relaxation. A large umbrella provides shade by the shimmering blue water.
Place to stay in San José
4.93 out of 5 average rating, 201 reviews

House in Punta Barco - Pool and Nature

Sun, breeze, nature, and tranquility. House 2 minutes away from the sea. Come and relax with all the amenities. We have: - 1 master bedroom (king size bed) with air conditioning, full bathroom - 1 room with queen bed, bunk bed, A/C, and full bathroom - 1 room with queen bed, bunk bed, air conditioning, and full bathroom - 1 room for service personnel: 1 bunk bed, fan and full bathroom. Private pool with sunbed, a practical bench, and a dining table. Large terrace with 3 hammocks.

Top guest favourite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonome
4.98 out of 5 average rating, 130 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Top guest favourite
A stone paved area features four wooden chairs arranged around a central fire pit, illuminated by soft landscape lighting. In the background, a cabin structure can be seen, bordered by lush greenery and softly lit paths, creating an inviting outdoor space.
Cabin in Provincia de Panamá Oeste
4.89 out of 5 average rating, 289 reviews

Buenavista Cabin by Casa Amaya

Casa Amaya is a cabin complex located one hour from the capital city, in Chicá de Chame, with pleasant temperatures between 18 and 24 degrees, where you can get in touch with nature and relax with your partner, friends or family. Other cabins: https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/panoramabycasaamaya https://www.airbnb.com/h/horizontebycasaamaya We have an electric generator in case of outages.

Guest favourite
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del Maria
4.81 out of 5 average rating, 318 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Guest favourite
Home in Altos del Maria
4.75 out of 5 average rating, 140 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Guest favourite
A small pool sits within a wooden deck area, surrounded by lush greenery. Steps lead from the deck to the pool, where a gentle waterfall feature adds a soothing element. Lounge chairs are positioned nearby for relaxation in a tranquil setting.
Guest house in Panamá Oeste
4.83 out of 5 average rating, 139 reviews

Mountain cabin with private pool

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Possibility of having 1 double bed and 2 single beds or 4 single beds. - Discount for two nights or more.

Superhost
Cabin in Altos del Maria
4.83 out of 5 average rating, 132 reviews

Cabin in Altos del María

Cozy cabin in Altos del María, ideal for couples looking to relax in a mountain setting. Enjoy a cold climate, surrounded by nature. It is pet-friendly and is equipped with the essential amenities: a room with a queen-size bed, sofa bed, and inflatable mattress, perfect for up to 4 people. It has a washing machine, grill, hammocks and guard post for added security. The atmosphere is conditioned to blend in with nature. Parking for 3 cars.

Top guest favourite
Camper van/Motorhome in El Valle de Antón
4.99 out of 5 average rating, 260 reviews

Armadillo Shelter & Garden Valle de Anton

It is a unique and special accommodation that we have designed for you to experience the Anton Valley in a more conscious and natural way. It's a remodeled RV or trailer, to make it cozy>functional and comfortable>tiny house style. The space has a small and complete kitchen, hot water, Wi-Fi, coffee and tea. It is surrounded by a nice garden. With a separate entrance and an area to park the car. Ideal for 1-2 people.

Top guest favourite
The modern two-story cabin features large glass windows that offer expansive views of the surrounding greenery. A spacious deck with seating is visible, surrounded by lush vegetation and natural stone pathways leading up to the entrance.
Cabin in Panamá Oeste
4.9 out of 5 average rating, 195 reviews

Altos del María Cabin La Loma de Styria

Relax with the whole family at this peaceful place to stay. It is a fantastic, cool and pleasant place where you can do many ecotourism activities, the best option if you want to have one of the best views you can imagine. Great for couples too. We have 2 bedrooms on the 2nd floor and 2 bathrooms. Multiple places to take beautiful photographs

Guest favourite
A pool area is visible with a clear blue pool surrounded by a concrete patio. Two lounge chairs are positioned beside the pool, and greenery from surrounding plants enhances the outdoor space. The area is framed by a shaded overhang, providing a comfortable retreat.
Home in Bejuco Chame
4.84 out of 5 average rating, 38 reviews

Country House - family Bejuco-Chame

This unique place has its own style. Suitable for celebrating birthdays, projects, working, writing and being totally at peace. Read a good book, give yourself a good pool therapy and share great moments and events with family or couple. In addition to being in an area of cultural experiences.

Popular amenities for Santa Cruz holiday rentals

  1. Airbnb
  2. Panama
  3. Panamá Oeste
  4. Santa Cruz