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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
Home in Playa Costa Esmeralda

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

LocationFamilyHospitality

4.98 out of 5 average rating, 222 reviews
Top guest favourite
The exterior of the cabin is depicted, featuring a stone wall and a metal roof. A manicured grass area surrounds the structure, with pine trees in the background against a bright blue sky, creating a serene environment.
Cabin in Chica

Horizonte Cabin by Casa Amaya

Take it easy at this unique and tranquil getaway at Cabaña Horizonte. Casa Amaya is a complex of 6 cabins located in Chicá de Chame, a cool climate between 18 and 24 degrees, where you can connect with nature and relax with your partner, friends or family. https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya We have an electric generator in case of power outages.

FamilyValueQuiet

4.94 out of 5 average rating, 321 reviews
Top guest favourite
A two-story white house is surrounded by lush greenery, featuring a blue roof and large windows. The spacious lawn showcases a hammock hanging beneath trees, inviting relaxation. Potted plants line the entrance, enhancing the natural setting of the property.
Home in Nueva Gorgona

Beachfront Private Family-Friendly House | Nature

Spectacular property with private access to the beach, garden, hammocks and panoramic view of the bay, just over an hour's drive from Panama City. A place with a lot of privacy and nature, it is perfect to relax, have a barbecue with the family, walk on the beach, lie in a hammock and enjoy the beautiful sunset with the sound of the sea. There are two wonderful caretakers in the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

FamilyValueWifi

4.96 out of 5 average rating, 45 reviews
Guest favourite
Home in Nueva Gorgona

Playa Malibu Beach House.

Wake up to the sound of the waves at this beautiful oceanfront home in Playa Malibu, where the beach is literally your backyard. Step outside and enjoy direct beach access, morning walks on the sand, and unforgettable sunsets over the water. The home features a private pool, BBQ area, and an outdoor dining space perfect for shared meals and long, laid-back evenings. Inside, the house offers a cozy, comfortable, and relaxed vibe, with all the essentials for a stress-free stay.

FamilyLocationPets

4.95 out of 5 average rating, 44 reviews
Guest favourite
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del María

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

LocationFamilyBack garden

4.82 out of 5 average rating, 337 reviews
Guest favourite
A modern kitchen area features sleek white cabinetry and a stainless steel dishwasher. A spacious lounge area is visibly arranged with a light grey sofa, a glass-top table, and two chairs, all complemented by large windows showcasing mountain views.
Apartment in Nueva Gorgona

Beachfront Oasis w/ Amazing Views & Amenities 1512

Welcome to the FABULOUS Royal Palm! This absolute beach-front property is only 50 minutes from Panama City and directly on the Pacific Ocean in Nueva Gorgona. This stunning condo project pays homage to the sea as the two residential towers mimic the hull of a ship along with large balconies and floor to ceiling windows. Guests will enjoy direct beach access with multiple swimming pools and social areas, a fitness center, and pickleball, tennis and basketball courts.

FamilyValueGetting around

4.96 out of 5 average rating, 56 reviews
Guest favourite
Home in Altos del María

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

ValueLocationHiking

4.76 out of 5 average rating, 172 reviews
Guest favourite
A small pool sits within a wooden deck area, surrounded by lush greenery. Steps lead from the deck to the pool, where a gentle waterfall feature adds a soothing element. Lounge chairs are positioned nearby for relaxation in a tranquil setting.
Guest house in Panamá Oeste

Mountain cabin with private pool

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Possibility of having 1 double bed and 2 single beds or 4 single beds. - Discount for two nights or more.

FamilyLocationCondition

4.84 out of 5 average rating, 166 reviews
Top guest favourite
A spacious living area features large windows that provide a view of the ocean. Comfortable seating options include a sectional sofa and armchairs. A round coffee table sits on a textured rug, while ceiling fans circulate air in the bright, airy space.
Apartment in Nueva Gorgona

Fabulous Beach Apartment-Ph Royal Palm-Gorgona

BEACHFRONT WITH DIRECT ACCESS TO THE BEACH FROM THE PH POOLS. Fabulous BEACH APARTMENT, beachfront unit, comfortable, unique, and perfect for relaxing with the family. It has 4 incredible pools, a Jacuzzi, a sauna, sports courts, board games, and beach access, plus restaurant service. Once you come, you'll never want to leave. Up to one (1) pet is allowed. IMPORTANT: For more information and announcements, please read the "Guest Access" section.

FamilyLocationLong stay

4.95 out of 5 average rating, 233 reviews
Guest favourite
Home in Las Lajas

Paradise house in a natural setting in Playa Coronado with a pool

Enjoy relaxing days with the whole family or your friends in this peaceful place with lots of nature! The beach is a 5-minute walk away. Many different shops are a 8-minute drive away. Two small shops are also a 5-minute walk away. Everything is taken care of in the house: air conditioning in every room, large 75" TV, washing machine, dryer, hair dryer, towels... everything you need. The pool provides refreshment – a place to feel good!

LocationFamilyAccess

4.94 out of 5 average rating, 35 reviews
Top guest favourite
An elevated view of the outdoor area shows a spacious green lawn with a large swimming pool at its center, surrounded by charming gazebos. Soft lighting outlines the pathways, while a backdrop of mountains creates a serene atmosphere amid lush trees.
Home in Altos del María

Your perfect mountain escape

Cottage in Altos Del Maria, Province of Panama Oeste, Chame District, Corregimiento de Sora, near Bejuco. Tourist location, 1500 m2 of construction, capacity for 28 people comfortably, 6 bedrooms with 2 double beds, master bedroom with king size bed and service room. Mountain house just an hour and a half from Panama City, suitable for holidays, family reunions, business, weddings, birthdays, Christmas or New Year, among others.

ValueFamilyPool

5.0 out of 5 average rating, 15 reviews
Guest favourite
Home in Bejuco

Country House with Pool / Villas del Maria

Relax in this quiet and elegant space. This place is perfect for groups of people, family trips, or a romantic gateway. Located in Sora, 5 minutes from Interamericana, 15 minutes from supermarkets and places to eat in Coronado. Villas del María is a safe and relaxing place to spend time as a family. Enjoy a cozy quiet place with everything you need for your stay. You and your family will love this place!

FamilyLocationAccuracy

4.86 out of 5 average rating, 22 reviews

Popular amenities for Santa Cruz holiday rentals