
Holiday rentals in Santa Cruz
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Top-rated holiday rentals in Santa Cruz
Guests agree: these stays are highly rated for location, cleanliness and more.

Beach House-Amazing Pool & Jacuzzi - Pet Friendly
Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.
4.98 out of 5 average rating, 222 reviews
Horizonte Cabin by Casa Amaya
Take it easy at this unique and tranquil getaway at Cabaña Horizonte. Casa Amaya is a complex of 6 cabins located in Chicá de Chame, a cool climate between 18 and 24 degrees, where you can connect with nature and relax with your partner, friends or family. https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya We have an electric generator in case of power outages.
4.94 out of 5 average rating, 319 reviews
Playa Malibu Beach House.
Wake up to the sound of the waves at this beautiful oceanfront home in Playa Malibu, where the beach is literally your backyard. Step outside and enjoy direct beach access, morning walks on the sand, and unforgettable sunsets over the water. The home features a private pool, BBQ area, and an outdoor dining space perfect for shared meals and long, laid-back evenings. Inside, the house offers a cozy, comfortable, and relaxed vibe, with all the essentials for a stress-free stay.
4.95 out of 5 average rating, 44 reviews
Modern House with Great Views and Heated Pool
Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.
4.82 out of 5 average rating, 337 reviews
Exclusive Beachfront apartment 1Hour from Pma City
SPECTACULAR FULLY EQUIPPED luxury apartment with 3 bedrooms (all with direct ocean view), 2 full bathrooms and a half guest bathroom; maid's room and bathroom. Fine finishes, 100% stainless steel kitchen and high-efficiency air conditioners throughout the apartment. Condominium with "Hotel Style Living" concept; restaurant and bar for the evenings (Thursday to Sunday), snack bar in the pool area and a Tiki Bar on the beach, as well as a volleyball court, tennis, basketball.
4.96 out of 5 average rating, 184 reviews
Villa Acuario
Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.
4.76 out of 5 average rating, 171 reviews
Paradise house in a natural setting in Playa Coronado with a pool
Enjoy relaxing days with the whole family or your friends in this peaceful place with lots of nature! The beach is a 5-minute walk away. Many different shops are a 8-minute drive away. Two small shops are also a 5-minute walk away. Everything is taken care of in the house: air conditioning in every room, large 75" TV, washing machine, dryer, hair dryer, towels... everything you need. The pool provides refreshment – a place to feel good!
4.94 out of 5 average rating, 35 reviews
Your perfect mountain escape
Cottage in Altos Del Maria, Province of Panama Oeste, Chame District, Corregimiento de Sora, near Bejuco. Tourist location, 1500 m2 of construction, capacity for 28 people comfortably, 6 bedrooms with 2 double beds, master bedroom with king size bed and service room. Mountain house just an hour and a half from Panama City, suitable for holidays, family reunions, business, weddings, birthdays, Christmas or New Year, among others.
5.0 out of 5 average rating, 15 reviews
Country House with Pool / Villas del Maria
Relax in this quiet and elegant space. This place is perfect for groups of people, family trips, or a romantic gateway. Located in Sora, 5 minutes from Interamericana, 15 minutes from supermarkets and places to eat in Coronado. Villas del María is a safe and relaxing place to spend time as a family. Enjoy a cozy quiet place with everything you need for your stay. You and your family will love this place!
4.86 out of 5 average rating, 22 reviews
Gorgeous Beachfront High Floor
Oceanfront escape! Bright 2BR/2BA condo with floor-to-ceiling windows, modern kitchen, and private balcony overlooking the turquoise sea. Relax in the spacious living area, enjoy stunning sunsets, or unwind in the stylish bedrooms with en-suite baths. Perfect for couples, families, or remote work with breathtaking views. Steps from the beach, dining & entertainment. Your dream coastal getaway awaits!
4.97 out of 5 average rating, 39 reviews
Spectacular Beachfront House
Beautiful house with private beach access right on the property. Relax on the hammocks and be surrounded by nature, with the best ocean view. Only 10 minutes drive from Coronado with all its amenities. There are two wonderful caretakers on the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.
5.0 out of 5 average rating, 42 reviews
Blue Sky Lodge; the best view in Altos del María
This luxury mountain cabin offers a modern design, quality finishes, and 180° panoramic views of mountains and sea. It is located in a secure gated community, surrounded by a green garden, with large glass windows that favor connection with nature. The climate is pleasant, with temperatures between 23°C and 28°C. .
4.94 out of 5 average rating, 68 reviewsPopular amenities for Santa Cruz holiday rentals
Other great holiday rentals in Santa Cruz

20th Flr Beachfront Nueva Gorgona, Panama 2/3 unit
4.89 out of 5 average rating, 71 reviews
The Dream of Playa Coronado
5.0 out of 5 average rating, 44 reviews
Luxury Beachfront Home • Private Pool • Coronado
4.89 out of 5 average rating, 18 reviews
Enjoy the view of Mount Picacho
4.9 out of 5 average rating, 86 reviews
Summer House
4.94 out of 5 average rating, 67 reviews
Jungle Sky Loft | Mountain & Ocean Views
4.94 out of 5 average rating, 31 reviews
Luxury Oceanfront Villa | Pool Sunset views | 5 Br
4.64 out of 5 average rating, 171 reviews
Roca de Toscana Lodge - Altos del Maria
5.0 out of 5 average rating, 6 reviewsDestinations to explore
- Panama City Holiday rentals
- Cahuita Holiday rentals
- Quepos Holiday rentals
- Bahía Ballena Holiday rentals
- Coveñas Holiday rentals
- Puerto Viejo de Talamanca Holiday rentals
- Bocas del Toro Province Holiday rentals
- Uvita Holiday rentals
- San Andrés Holiday rentals
- Rio Hato Holiday rentals
- Boquete Holiday rentals
- El Valle Holiday rentals





