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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
Home in Playa Costa Esmeralda
4.98 out of 5 average rating, 219 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Top guest favourite
A two-story white house is surrounded by lush greenery, featuring a blue roof and large windows. The spacious lawn showcases a hammock hanging beneath trees, inviting relaxation. Potted plants line the entrance, enhancing the natural setting of the property.
Home in Nueva Gorgona
4.95 out of 5 average rating, 43 reviews

Beachfront Private Family-Friendly House | Nature

Spectacular property with private access to the beach, garden, hammocks and panoramic view of the bay, just over an hour's drive from Panama City. A place with a lot of privacy and nature, it is perfect to relax, have a barbecue with the family, walk on the beach, lie in a hammock and enjoy the beautiful sunset with the sound of the sea. There are two wonderful caretakers in the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

Guest favourite
Home in Nueva Gorgona
4.95 out of 5 average rating, 38 reviews

Playa Malibu Beach House.

Wake up to the sound of the waves at this beautiful oceanfront home in Playa Malibu, where the beach is literally your backyard. Step outside and enjoy direct beach access, morning walks on the sand, and unforgettable sunsets over the water. The home features a private pool, BBQ area, and an outdoor dining space perfect for shared meals and long, laid-back evenings. Inside, the house offers a cozy, comfortable, and relaxed vibe, with all the essentials for a stress-free stay.

Superhost
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del María
4.82 out of 5 average rating, 332 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Guest favourite
Home in Altos del María
4.76 out of 5 average rating, 164 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Superhost
Home in Bejuco
4.85 out of 5 average rating, 20 reviews

Country House with Pool / Villas del Maria

Relax in this quiet and elegant space. This place is perfect for groups of people, family trips, or a romantic gateway. Located in Sora, 5 minutes from Interamericana, 15 minutes from supermarkets and places to eat in Coronado. Villas del María is a safe and relaxing place to spend time as a family. Enjoy a cozy quiet place with everything you need for your stay. You and your family will love this place!

Guest favourite
The outdoor area is illuminated at night, featuring a large swimming pool and a separate jacuzzi. Surrounding palm trees and soft lighting enhance the tranquil ambiance. A thatched-roof pavilion stands nearby, with a shaded area for relaxation, all set within a spacious lawn.
Home in Coloncito
4.82 out of 5 average rating, 71 reviews

Beautiful beach villa

Welcome to your perfect vacation retreat! This beautiful house has everything you need to relax and have fun. Enjoy the pool, hot tub, and game room. With 3 spacious bedrooms and 4 comfortable hammocks, there's space for the whole family or group of friends. Plus, we're just 5 minutes from the beach, so you can enjoy the sun, sand, and sea. Book now and start your dream vacation!

Superhost
Cabin in Sora
5.0 out of 5 average rating, 4 reviews

Blue Sky Suites; colder weather in Altos del María

This luxury suite style cabin in the mountain offers a modern design, quality finishes, and amazing views of the mountains. It is located in a secure gated community, surrounded by a green garden, with large glass windows that favor connection with nature. The weather is pleasant, with temperatures between 18°C and 28°C.

Guest favourite
A pool area is visible with a clear blue pool surrounded by a concrete patio. Two lounge chairs are positioned beside the pool, and greenery from surrounding plants enhances the outdoor space. The area is framed by a shaded overhang, providing a comfortable retreat.
Home in Bejuco Chame
4.87 out of 5 average rating, 47 reviews

Country House - family Bejuco-Chame

This unique place has its own style. Suitable for celebrating birthdays, projects, working, writing and being totally at peace. Read a good book, give yourself a good pool therapy and share great moments and events with family or couple. In addition to being in an area of cultural experiences.

Top guest favourite
A spacious bed is dressed in a colorful quilt, complementing an inviting orange pillow. Large glass doors offer a panoramic view of the surrounding mountains and lead to a private outdoor space with a swimming pool.
Tiny home in Panama City
4.97 out of 5 average rating, 268 reviews

Mountain cabin in Altos del María

The cabin in Altos del María is located in the heart of the mountain, with beautiful landscapes, trees, animals, monkeys, birds, just minutes from picnic areas, outdoor games, river, waterfall, trails and viewpoints. Escape into nature! Close to everything, away from the daily grind!

Superhost
An outdoor area features modern seating arranged around a central fire pit, surrounded by gravel and stone pathways. Elevated swings are positioned for relaxation, with a backdrop of expansive mountain views. Natural light filters through a structured canopy, enhancing the spacious feel.
Cabin in Chame
4.85 out of 5 average rating, 157 reviews

Walk through the Clouds

Relax on this unique and quiet getaway just an hour and a half from the city. Every corner of this magical place was meticulously designed to provide the perfect escape for couples seeking intimacy, serenity, and unforgettable moments together.

Guest favourite
A well-maintained outdoor space features a lush green lawn, palm trees, and a clear pool. A covered patio with dining options is visible, alongside natural rock formations that enhance the tranquil setting.
Villa in Chame
4.93 out of 5 average rating, 14 reviews

Beach house with a pool and a hot tub

Create unforgettable memories in this unique and family-friendly accommodation, spacious to share, with an excellent location, safe, 15 minutes from the beach and 10 minutes from all shopping centers, pharmacies, supermarkets etc.

Popular amenities for Santa Cruz holiday rentals