
Holiday rentals in Santa Cruz
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Santa Cruz
Guests agree: these stays are highly rated for location, cleanliness and more.

Beach House-Amazing Pool & Jacuzzi - Pet Friendly
Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Beachfront Private Family-Friendly House | Nature
Spectacular property with private access to the beach, garden, hammocks and panoramic view of the bay, just over an hour's drive from Panama City. A place with a lot of privacy and nature, it is perfect to relax, have a barbecue with the family, walk on the beach, lie in a hammock and enjoy the beautiful sunset with the sound of the sea. There are two wonderful caretakers in the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

Playa Malibu Beach House.
Wake up to the sound of the waves at this beautiful oceanfront home in Playa Malibu, where the beach is literally your backyard. Step outside and enjoy direct beach access, morning walks on the sand, and unforgettable sunsets over the water. The home features a private pool, BBQ area, and an outdoor dining space perfect for shared meals and long, laid-back evenings. Inside, the house offers a cozy, comfortable, and relaxed vibe, with all the essentials for a stress-free stay.

Modern House with Great Views and Heated Pool
Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Summer House
Bring the whole family to this fantastic place with lots of fun areas. Close to all the amenities of Coronado, a few minutes from beaches, San Carlos lagoon and just an hour and a half from the city. The PH has a PH pool and a private pool, in a quiet and spacious area. You will find 4 supermarkets, pharmacies, private hospital (emergency). Close to country activities, beaches, mountains, lake. It has a gazebo with all the amenities. The place is safe and complete.

Villa Acuario
Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Mountain cabin with private pool
Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Possibility of having 1 double bed and 2 single beds or 4 single beds. - Discount for two nights or more.

Country House with Pool / Villas del Maria
Relax in this quiet and elegant space. This place is perfect for groups of people, family trips, or a romantic gateway. Located in Sora, 5 minutes from Interamericana, 15 minutes from supermarkets and places to eat in Coronado. Villas del María is a safe and relaxing place to spend time as a family. Enjoy a cozy quiet place with everything you need for your stay. You and your family will love this place!

Blue Sky Suites; colder weather in Altos del María
This luxury suite style cabin in the mountain offers a modern design, quality finishes, and amazing views of the mountains. It is located in a secure gated community, surrounded by a green garden, with large glass windows that favor connection with nature. The weather is pleasant, with temperatures between 18°C and 28°C.

Country House - family Bejuco-Chame
This unique place has its own style. Suitable for celebrating birthdays, projects, working, writing and being totally at peace. Read a good book, give yourself a good pool therapy and share great moments and events with family or couple. In addition to being in an area of cultural experiences.

Mountain cabin in Altos del María
The cabin in Altos del María is located in the heart of the mountain, with beautiful landscapes, trees, animals, monkeys, birds, just minutes from picnic areas, outdoor games, river, waterfall, trails and viewpoints. Escape into nature! Close to everything, away from the daily grind!

Walk through the Clouds
Relax on this unique and quiet getaway just an hour and a half from the city. Every corner of this magical place was meticulously designed to provide the perfect escape for couples seeking intimacy, serenity, and unforgettable moments together.
Popular amenities for Santa Cruz holiday rentals
Other great holiday rentals in Santa Cruz

Beautiful beach villa

La Florecita - Country house in Valle de Antón

Family Paradise | Pool, Jacuzzi & Garden

Paradise house in a natural setting in Playa Coronado with a pool

Gorgeous & Serene Beachfront 2 Bedroom RP 1603

La Casita Encantada #3 by AcoModo

Santa Fe de Lajas Chame, Panama.

Jungle Sky Loft | Mountain & Ocean Views
Destinations to explore
- Panama City Holiday rentals
- Cahuita Holiday rentals
- Quepos Holiday rentals
- Bahía Ballena Holiday rentals
- Coveñas Holiday rentals
- Puerto Viejo de Talamanca Holiday rentals
- Bocas del Toro Province Holiday rentals
- Uvita Holiday rentals
- Boquete Holiday rentals
- San Andrés Holiday rentals
- Rio Hato Holiday rentals
- El Valle Holiday rentals





