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Holiday rentals in Santa María

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Top-rated holiday rentals in Santa María

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guest house in El Valle de Antón
4.99 out of 5 average rating, 114 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Top guest favourite
A serene evening scene features the bohío cottage with its thatched roof, surrounded by lush greenery and potted plants. The moon is visible in the sky above, casting a gentle glow on the outdoor area, near the tranquil pool reflecting the soft outdoor lighting.
Place to stay in Santa Clara
5 out of 5 average rating, 25 reviews

Paradise from ocean to jungle. Bohío cottage

Welcome to our beach house 850meters to beautiful pacific beach & 3 beach restaurants . Our house is gated and in a safe area .Many areas to visit nearby from surf areas to crater town in the mountains ! Hikes , Canyons , waterfalls ! Coronado is a 35 min drive with all conveniences .New mall is 10 min drive to grocery store , large drugstore. Fish market is 5 min . Seasonal riohato airport 5 min. . Our 1/4 acre property & house is on a country lane with some lovely estates surrounding it.

Superhost
A single-story house is nestled beneath a large tree, featuring a tiled roof and a covered parking area. Surrounding greenery includes bushes and ornamental plants, enhancing the natural setting. The house is positioned to provide a sense of privacy and tranquility.
Home in Chitre
4.86 out of 5 average rating, 65 reviews

Country House Like in the City / La Casita

Casa fresca, con árboles y naturaleza. Áreas amplias para descansar. Ubicación céntrica, cerca de malls, restaurantes, estación de buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Ahora, Chitré, tiene un problema con el agua: no está potable; tenemos 50% de lo habitual, a veces estamos sin agua por algunas horas. Por favor, consulten antes de reserar.

Superhost
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.85 out of 5 average rating, 26 reviews

Country House in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Guest favourite
A wooden deck extends from the entrance, featuring two chairs positioned to enjoy the outdoor environment. The entrance leads into a well-lit interior space, framed by lush greenery that enhances the tranquil setting.
Cabin in El Valle de Antón
4.87 out of 5 average rating, 126 reviews

5 min from Valle I Cabaña Vista 1 - Free coffee

🌿 Cabaña Moderna en la Naturaleza – Cerca de El Valle • 🏡 Cabaña moderna rodeada de naturaleza • 📍 A 5 min de Valle de Antón • 🛏️ Espacio tipo estudio: camas, cocina y desayunador integrados • 🍳 Estufa eléctrica (sin horno) y cafetera • 📺 TV • 🌄 Terracita con linda vista • 🐶 Hasta 2 perros pequeños permitidos • 🚗 Pasan todo tipo de auto (ultimos 3 minutos es calle de piedra) • 🫒 Café, azúcar, sal, pimienta, crema y aceite de oliva de cortesía • 🕒 3 pm | 🕛 12 md

Guest favourite
A modern living area features a light-colored sofa and a wooden coffee table. Large glass sliding doors provide a clear view of the ocean and greenery outside. A decorative plant adds a touch of nature, while soft light fills the space.
Flat in Rio Hato
4.94 out of 5 average rating, 86 reviews

Ocean View Marina Stay in Buenaventura | By Alura

Enjoy an exceptional stay in this elegant and modern apartment, located on the top floor in the marina in Buenaventura, Panama’s most exclusive beach resort. It offers panoramic views of the Pacific Ocean and the Marina. The apartment is fully equipped with high-quality furniture and finishes, thoughtfully designed to provide both comfort and style. You’ll also have access to beach clubs, restaurants, and more, for a truly unforgettable resort experience.

Top guest favourite
Home in Canto del Llano
4.92 out of 5 average rating, 24 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Superhost
A large lagoon-style pool is visible, surrounded by palm trees and well-kept gardens. The expansive water reflects the blue sky and clouds, with several lounge chairs positioned along the poolside for relaxation.
Apartment in Playa Blanca-Farrallon (Distrito de Antón)
4.86 out of 5 average rating, 165 reviews

Playa Blanca-Spacious waterfront paradise

Conveniently located at 120 km from Panama City in Playa Blanca. Tastefully equipped 88 m2, one bedroom apartment offering more comfort than nearby hotels. Confy bed, lovely terrasse, good bathroom, fully equipped kitchen. The best view to the giant pool. Next to the sport center. Air conditioning, WIFI, cable TV included. Suitable for max. 4 persons. Access to giga salted pool also included it means that you can use the big pool in two parts.

Guest favourite
A cozy sleeping area features a spacious bed with neutral bedding. Soft lighting is provided by bedside lamps, and a ceiling fixture adds warmth. Two framed art pieces adorn the walls, offering a subtle contrast to the light decor.
Tiny home in Penonome
4.83 out of 5 average rating, 66 reviews

Fenced and Pet-Friendly Cottage in Penonomé

Cozy private cottage, fully fenced — perfect for relaxing, remote work, or traveling with your pet. Enjoy the garden surrounded by greenery, rest in the covered hammocks, or do some birdwatching. Equipped kitchen, air conditioning, high-speed WiFi, and secure on-site parking. Just minutes from the Interamerican Highway, with easy access to cafés, shops, and more. Ideal for a peaceful getaway or productive stay.

Guest favourite
Farm stay in Santa Fe
4.9 out of 5 average rating, 312 reviews

Sun Cabin at Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favourite
Cottage in Santa Fe
4.89 out of 5 average rating, 9 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Top guest favourite
A bright bedroom is displayed, featuring a spacious bed covered with a textured white blanket. A television is mounted on the wall opposite the bed. Natural light floods through large windows, accompanied by sheer curtains. A cozy orange chair and potted plant add a touch of warmth.
Tiny home in Playa El Jobo
4.97 out of 5 average rating, 33 reviews

Little home near to the beach -Las Tablas

10 min drive- Las Tablas Get away from it all when you stay under the stars. A room very close to the sea, with an open kitchen that will allow you to disconnect and enjoy the view and nature in Las Tablas. You can plan to visit nearby beaches or take a walk through Pedasí, 30 minutes from Las Tablas.

Popular amenities for Santa María holiday rentals

  1. Airbnb
  2. Panama
  3. Herrera
  4. Santa María