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Holiday rentals in Santa María

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Top-rated holiday rentals in Santa María

Guests agree: these stays are highly rated for location, cleanliness and more.

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Two dome structures are positioned on a terrace overlooking a lush green valley. A vibrant sunset casts warm colors across the sky, with scattered clouds creating depth. String lights are visible along the railing, enhancing the natural setting adorned with trees.
Dome in El Valle de Antón
4.87 out of 5 average rating, 103 reviews

5 min from Valle I Domo No. 7-Free coffee

🌄 Dome in El Valle – Nature, peace and incredible views • 🆕 New dome, queen-size bed, Wi-Fi • 🚿 Private en-suite bathroom • 🌬️ Cool mountain climate all year round • 🌿 Surrounded by greenery • 🌄 Stunning views • 🐶 1 small pet • ❄️ Fridge, microwave and coffee maker (no kitchen) • ☕ Welcome courtesy: Small quantities of coffee, sugar and milk for the start of your stay. • 🚗 5 minutes before El Valle (the last two minutes are along a stony track; small cars can pass) • 🕒 3 pm | 🕛 12 pm

Top guest favourite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guest house in El Valle de Antón
4.99 out of 5 average rating, 124 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Guest favourite
Guest house in El Valle de Antón
4.93 out of 5 average rating, 102 reviews

The Retreat in El Valle - Garden House

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Top guest favourite
Home in Costa Esmeralda
4.98 out of 5 average rating, 211 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Top guest favourite
Cabin in Penonome
4.98 out of 5 average rating, 132 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Top guest favourite
A private pool is visible in the foreground, surrounded by a covered seating area with arranged outdoor furniture. Lush greenery is seen in the background, contributing to a serene environment. A gas grill and additional seating are positioned nearby under the protective roof.
Home in San Carlos
4.91 out of 5 average rating, 161 reviews

El Palmar, beach 50 meters away

Listen to the waves from the privacy of our terrace and create unforgettable memories in this unique and family-friendly accommodation just steps from the beach with a private pool. El Palmar is a quiet community with several restaurants available a few steps from the house. The property is fully fenced for the tranquility and safety of children and their pets. In addition, you have wifi, cable TV in both rooms and air conditioning in the dining room and in all the bedrooms

Guest favourite
Guest house in Panamá Oeste
4.84 out of 5 average rating, 143 reviews

Mountain cabin with private pool

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Possibility of having 1 double bed and 2 single beds or 4 single beds. - Discount for two nights or more.

Guest favourite
The modern house is set against a backdrop of rolling mountains, illuminated by the soft glow of evening light. A spacious entrance is visible, with large sliding doors opening to inviting communal areas. Lush greenery surrounds the property, enhancing its natural appeal.
Villa in El Copé
4.92 out of 5 average rating, 190 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Top guest favourite
An inviting outdoor lounge area is enhanced by soft lighting from decorative hanging fixtures. A hammock is suspended nearby, surrounded by lush greenery. Comfortable seating features a rustic wooden frame, offering a cozy space to relax and enjoy the garden view.
Home in El Valle de Antón
4.96 out of 5 average rating, 190 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Top guest favourite
Camper van/Motorhome in El Valle de Antón
4.99 out of 5 average rating, 265 reviews

Armadillo Shelter & Garden Valle de Anton

It is a unique and special accommodation that we have designed for you to experience the Anton Valley in a more conscious and natural way. It's a remodeled RV or trailer, to make it cozy>functional and comfortable>tiny house style. The space has a small and complete kitchen, hot water, Wi-Fi, coffee and tea. It is surrounded by a nice garden. With a separate entrance and an area to park the car. Ideal for 1-2 people.

Top guest favourite
Cottage in El Valle de Antón
4.99 out of 5 average rating, 161 reviews

Casa Campestre Los Macos, El Valle de Anton

🏡 Welcome to Casa Campestre Los Macos, a cozy retreat located in the green heart of El Valle de Antón, inside an extinct volcanic crater, the largest inhabited in the world. It is an experience of total rest, in a safe and quiet area, ideal for lovers of nature, silence and fresh air. You'll wake up to birdsong, enjoy a cup of coffee in the garden, and spend family evenings in a fully equipped house.

Guest favourite
Home in El Valle de Antón
4.93 out of 5 average rating, 67 reviews

La Florecita - Country house in Valle de Antón

Cozy getaway in the heart of the Anton Valley Enjoy an unforgettable stay in our warm and cozy house, ideal for families and groups of friends. Located in the center of the Anton Valley, you'll be minutes away from markets, restaurants, and major natural attractions. Our house combines comfort and charm, with spacious spaces perfect for relaxing and enjoying the cool mountain climate.

Popular amenities for Santa María holiday rentals

  1. Airbnb
  2. Panama
  3. Herrera
  4. Santa María