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Lake house holiday rentals in Seneca
Find and book unique lake houses on Airbnb
Top-rated lake house rentals in Seneca
Guests agree: these lake houses are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for Seneca lake house rentals
Waterfront lakehouse rentals
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Home in Townville
4.94 out of 5 average rating, 153 reviewsZoey’s Cottage on Lake Hartwell w/dock- Secluded
![](https://a0.muscache.com/im/pictures/3322511e-b633-44ff-b28f-7144e742a402.jpg?im_w=720)
Home in Townville
4.99 out of 5 average rating, 102 reviewsSweet Serenity - Rest Relax Enjoy
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Home in Seneca
4.92 out of 5 average rating, 76 reviewsCharming Secluded Lake House Convenient to Clemson
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Home in Fair Play
5 out of 5 average rating, 7 reviewsWaterfall Cove - Prime
![](https://a0.muscache.com/im/pictures/miso/Hosting-1114484551768859089/original/4303d18d-a61f-480d-8394-f36f7e166c6b.jpeg?im_w=720)
Home in Seneca
5 out of 5 average rating, 3 reviewsSweet Tea Retreats Lake Keowee
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Home in Seneca
4.81 out of 5 average rating, 16 reviewsLake Hartwell Beauty with Dock. Minutes to Clemson
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Home in Seneca
5 out of 5 average rating, 5 reviewsLake House Retreat Near Clemson
![](https://a0.muscache.com/im/pictures/miso/Hosting-570310677162891915/original/7de533ec-9d03-4355-8839-166346327b89.jpeg?im_w=720)
Home in Seneca
4.95 out of 5 average rating, 56 reviewsGood Times @ Clemson / Lake Hartwell
Pet-friendly lake house rentals
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Home in Hartwell
4.93 out of 5 average rating, 107 reviewsLake house waterfront, 10 min to downtown w Kayaks
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Home in Greenville
4.99 out of 5 average rating, 141 reviewsPark Cottage at State Park -15min Dwtn GVL, Furman
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Home in Easley
4.91 out of 5 average rating, 134 reviewsLarge lake house - 15 min to Downtown Greenville
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Home in Seneca
4.93 out of 5 average rating, 89 reviewsThe Marina House, at the edge of Lake Keowee.
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Home in Seneca
4.93 out of 5 average rating, 98 reviewsGetaway on Lake Hartwell: Pontoon Rental, Clemson
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Home in Seneca
4.89 out of 5 average rating, 18 reviewsVacation home 15 mins/Clemson, 7 mins lake Keowee
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Home in Seneca
4.96 out of 5 average rating, 25 reviewsNew! Peaceful Lakefront Home on Keowee!
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Home in Townville
5 out of 5 average rating, 21 reviewsFish, boat, swim and relax on Lake Hartwell
Private lake house rentals
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Home in Townville
5 out of 5 average rating, 26 reviewsEntire Lake house on deep water cove.
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Home in Tamassee
5 out of 5 average rating, 29 reviewsWhitewater Lake Front Cottage
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Home in Anderson
4.98 out of 5 average rating, 41 reviewsThe Shanty on Waites
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Home in Seneca
5 out of 5 average rating, 38 reviewsQuiet Lake Home 5 Min to Clemson
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Home in Salem
4.87 out of 5 average rating, 15 reviewsKeowee Key - Lake, deck, golf & tennis!
![](https://a0.muscache.com/im/pictures/89707590/29b576c0_original.jpg?im_w=720)
Home in Seneca
4.9 out of 5 average rating, 60 reviewsLake House near Clemson WiFi Kayaks 65" TV Grill
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Home in Salem
5 out of 5 average rating, 9 reviewsNewly Updated | Lake Keowee | Pool | Amenities
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Home in West Union
4.93 out of 5 average rating, 83 reviewsKayaker’s Dream House
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