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Guest house holiday rentals in Santa Cruz

Find and book unique guest house rentals on Airbnb

Top-rated guest house rentals in Santa Cruz

Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

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Guest favourite
A cozy space features a spacious bed adorned with decorative towels, complemented by patterned curtains and wall accents. A dining table with chairs is positioned near the open kitchen, which includes a stove and sink. Natural light filters in through a window, enhancing the inviting atmosphere.
Guest house in Samaipata
5 out of 5 average rating, 6 reviews

La Casita, Finca La Vispera

La Casita, is a perfect place to spend a couple of days with your partner, it is located inside Finca "La Vispera", we have a Parque Nativo, Café Jardín, Herbolario, great view. You’ll love my place because of the location, the people, the neighborhood, the outdoors space, and the ambiance. My place is good for couples, solo adventurers, families (with kids), big groups, and furry friends (pets). You also will enjoy our vegetable Garden. You can collect the vegetables and enjoy a great meal.

A multi-story building is showcased, featuring a distinctive red facade with decorative archways. Balconies extend from the upper floors, providing outdoor space. The ground level houses various storefronts, while utility poles and street signs are visible, indicating a lively urban environment.
Guest house
4.42 out of 5 average rating, 12 reviews

Cozy family home in Santa Cruz de la Sierra

Family house of 320 square meters, on the second floor, with all the utensils and household clothes, wonderful views from its 30 meters of terrace. Ideal for families who want to have a quiet stay of any duration in the City of Santa Cruz de la Sierra. Very well connected with several bus lines that take you throughout the city and surroundings and very close to the Sanctuary of Cotoca. In the vicinity has all kinds of services, breakfasts, meals, markets, shops, etc..

A cozy living space is presented with a comfortable sectional sofa featuring decorative cushions. A coffee table sits in front, with a sleek television mounted on a modern cabinet. Natural light enters through large windows, and a potted plant adds a touch of greenery.
Guest house in Santa Cruz de la Sierra

Horizontal duplex in the backyard of a house with a pool

Enjoy a semi-detached duplex (complete) in the backyard of my house. With its own entrance to the duplex, it shares an entrance to the property. Located in a safe and quiet area easily accessible, close to shops, markets, supermarkets, pharmacy, public transportation (blocks from the main avenues), by car 10 min. from the center, 5 min. from the Fexpo, 30 to 40 min. from the airport, 1 block walk from the society of engineers SIB, clinic Montalvo and Urbari.

Superhost
A charming outdoor patio is framed by lush green trees, providing a shaded area for relaxation. The brick flooring leads to a set of steps ascending to a bright entrance flanked by large windows, allowing natural light to enter the interior space.
Private room in La Guardia
4.64 out of 5 average rating, 14 reviews

Casiopea Eco-Friendly Room

Relax and enjoy a moment with nature, 10 minutes from the municipality of the guard and 3 minutes from La Tranca al Torno entering by dry pipe. Room with air conditioning, bed for 2 people and 1/2 with option to add 1 or 2 extra mattresses; grill, electricity , water, wifi, ample space for walking on trails. Fruit trees, easy access with shops nearby to stock up on food. Owners live on site..

A spacious common area features comfortable seating arrangements with a mix of sofas and chairs. A central table is set with placemats, while a ceiling fan and air conditioning unit contribute to a comfortable environment. Light filters through large windows, enhancing the welcoming feel.
Guest house in Santa Cruz de la Sierra

Spacious house with a patio and parking

Guest house, with large patio and grill (churrasquera), in a very quiet area. A/C in all environments, thermotank (hot water), Wi-Fi, spacious living room. Suite with private bathroom. Common bathroom, sofa-bed and spacious sofa on the ground floor. (Can sleep comfortably up to 4 people) Address: km 8, Barrio 14 de Agosto, Calle 3 Between double via guard and radial 17 and a half

Guest favourite
Private room in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviews

Room in the center, two minutes from everything!

Experience staying in the heart of Santa Cruz, just 3 blocks from the main square. Our bright and cozy room awaits you in a safe and lively area: museums, cafes, bars, shops and historical spots are just a few steps away. Ideal for those looking for comfort, style and an unbeatable location. With WiFi, details designed for your rest and attention that will make you feel at home.

Guest house

Complete centric apartment with garden and pool

Complete centric apartment with an enormous garden and pool. Private apartment with fully staffed kitchen, private bathroom and a bedroom with a queensized bed. You'll also have access to the big garden and the pool to relax and refresh yourself. By choosing our accommodation, you’re also supporting Ñañope, a local NGO dedicated to empowering household workers in Santa Cruz.

A well-equipped kitchen features wooden cabinets and a countertop with colorful tiles. A small refrigerator and an oven are included, alongside a wooden dining table with four chairs, creating a functional space for meal preparation and dining.
Guest house in Santa Cruz de la Sierra
5 out of 5 average rating, 56 reviews

Lodge surrounded by nature in the city

We renewed our lodge for more comfort for our guests: Imagine a little house surrounded by trees and plants, easy to go and not far away from city center. We´re living on half a hectar and your new place for working o relaxing is inside this paradise. You´re completely independent from us, with all you need for taking a rest or work, including the swimming pool.

A simple sleeping area features a spacious bed with white linens and bright red curtains framing a nearby window. An open shelf housing no items stands against one wall. A doorway leads to a bathroom visible in the reflection of a mirrored door.
Guest house in Ichilo
4.5 out of 5 average rating, 14 reviews

Window to Amboro Park

Enjoy a partial view of the Amboro mountains, with birdsong in the morning and the sounds of the small forest at night. Sometimes nocturnal monkeys or early-rising agoutis may appear. Though only 4 blocks from the main square, the place is quiet, away from traffic noise. With advance confirmation, tours to the north side of Amboro National Park can be arranged.

Private room in Santa Cruz de la Sierra
4.5 out of 5 average rating, 4 reviews

Double or Full Room in Downtown

New and elegant building located just 2 blocks from the main square, surrounded by shopping malls, restaurants, cafes, jewelry, perfumerias, perfumerias, it is located a couple of blocks from the house of culture, the cathedral, museums, 1 block, banks, 7 street market and various shops and locals.

Guest favourite
A cozy bedroom features a spacious bed dressed in neutral linens, accompanied by decorative cushions. Two wooden chairs are positioned beside a round table near a window with light curtains. A wooden nightstand stands beside the bed, contributing to the room's welcoming atmosphere.
Guest house in Santa Cruz de la Sierra
4.88 out of 5 average rating, 109 reviews

Private Apartment In Downtown

Welcome to our cozy guest house in one of the most beautiful and safe areas of the center! Just 6 blocks from Plaza 24 de Septiembre, our historic neighborhood offers you a unique experience.

Guest house in Santa Cruz de la Sierra

Casa Portal Holístico # 1

Enjoy this mystical space of tranquility and harmony where your nights will be restored and revitalizing with the energy of the Holistic Portal

Popular amenities for guest house rentals in Santa Cruz