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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Flat in Santa Cruz de la Sierra
4.9 out of 5 average rating, 21 reviews

Luxury apartment in Equipetrol | SKY Moon

Enjoy an experience with a unique style, just a stone's throw from Mall Ventura, Mz-40, Green Tower and the Hotel Camino Real. Elegant studio in SKY MOON, Equipetrol Norte. Furnished studio with a bed, a comfortable sofa, a desk, a fully equipped kitchen, a private bathroom and a balcony. Great for business trips or rest. Enjoy hotel-style amenities: pool, sauna, gym, coworking, billiards, paddle tennis court and terrace with fireplace in the best business area of Santa Cruz. Book and enjoy the experience today

Top guest favourite
The living area features a comfortable couch positioned near a large window, allowing natural light to fill the space. A flat-screen television is mounted on a wood-paneled wall, and a small round table is visible nearby. The view showcases the city skyline and nearby greenery.
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 34 reviews

Luxury, comfort, ideal location

Bienvenidos a la mejor ubicación de Santa Cruz! En el corazón del centro empresarial, pero en una calle tranquila. Supermercados y mucho más a la vuelta de la esquina. A pocos pasos encontrarás decenas de restaurantes increíbles: parrillada, comida japonesa, italiana o americana. Comida rápida o cenas elegantes. Manzana 40 está a 10 minutos a pie. Ventura Mall está a solo 5 min en auto. Ya sea para trabajo o diversión, este es el lugar ideal! El edificio cuenta con personal de seguridad 24/7.

Guest favourite
Flat in Santa Cruz de la Sierra
5 out of 5 average rating, 6 reviews

Skyline Luxury • Rooftop, Piscina, Billar & Lounge

Diseñado para huéspedes de gustos exigentes que buscan una experiencia superior a un hotel 5 estrellas. Ubicado en Equipetrol, la zona más exclusiva y segura de Santa Cruz, este elegante Dpto. en penúltimo piso ofrece doble balcón con vistas únicas! Premium amenities como sky pool, lounge, billar, churrasqueras, gym completo y más! Rodeado de los mejores restaurantes, bares, cafés, teatros, tiendas y centros empresariales. Ideal para viajes ejecutivos, escapadas de lujo o estadías inolvidables.

Guest favourite
A modern living area is displayed, featuring a comfortable sofa and a green accent pouf. A dining table is situated nearby. Floor-to-ceiling windows offer a view of the greenery outside, allowing natural light to fill the space. The kitchen is equipped with sleek appliances.
Flat in Santa Cruz de la Sierra
4.91 out of 5 average rating, 156 reviews

Studio 518 - Luxury near Everything

Acceso automático, 2 Aires Acondicionados, Lavadora, Cocina, Sofa y TV perfecto para trabajar todo el día con una vista verde de un 8 piso desde el barrio más cotizado de la ciudad, Equipetrol. Si te aburres puedes usar la piscina sin costo, áreas sociales, asado BBQ. Si te aburres más estarás a 2 minutos de Supermercados, Farmacias a cuadras de la principal de Equipetrol con Restaurantes renombrados, a 5 min de la Plaza Central o a 5 min del shopping más grande de Bolivia, Ventura Mall.

Top guest favourite
Flat in Santa Cruz de la Sierra
5 out of 5 average rating, 19 reviews

POX | Green Tower 17th Floor, Luxury in Equipetrol

✨ Vive la experiencia POX de lujo y confort en el corazón de Equipetrol ✨ Ubicado en el piso 17 de la exclusiva Green Tower, este departamento POX Glam combina diseño moderno, decoración sofisticada y una vista panorámica única de Santa Cruz. Perfecto para viajeros de negocios, parejas o estadías de placer que buscan un espacio premium con todas las comodidades. En POX no solo alquilamos departamentos: te damos un hogar lejos de casa. Nuestro equipo está disponible 24/7 para ayudarte.

Guest favourite
A contemporary entryway featuring sleek, metallic walls and smooth marble flooring. A minimalist reception desk with soft ambient lighting displays the name 'NUU.' A large potted plant adds a touch of greenery, while well-placed lighting creates a bright atmosphere.
Flat in Santa Cruz de la Sierra
4.92 out of 5 average rating, 76 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

Top guest favourite
A comfortable sleeping area features a spacious bed adorned with soft pillows and a decorative throw. Warm bedside lamps illuminate the space, while large windows offer views of the surrounding cityscape and allow natural light to brighten the room.
Flat in Santa Cruz de la Sierra
4.98 out of 5 average rating, 135 reviews

13° SmartLife - Luxury Equipetrol

Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

Guest favourite
A rooftop pool is viewed from the edge, featuring clear blue water reflecting the sunlight. Surrounding glass panels offer an unobstructed view of the skyline and horizon.
Apartment in Santa Cruz de la Sierra
4.93 out of 5 average rating, 41 reviews

Luxury Apartment in Equipetrol

Modern apartment located in the prestigious area of Equipetrol, with 2 bedrooms and 2 bathrooms, ideal for vacations or business trips, surrounded by restaurants, cafes, shops and much more. Enjoy amenities like air conditioning, Alexa-controlled speakers and switches, plus a 55" TV with Netflix, Disney + Starplus, and HBO Max. The terrace with swimming pool, 2 barbecue areas, Cowork and Netflix room complete this unique offer.

Superhost
Cottage in Samaipata
4.96 out of 5 average rating, 25 reviews

EcoHouse · Swimming pool · Nature · Tranquillity · Samaipata

A living-earth sanctuary on Samaipata Mountain. Handcrafted using natural materials, with a Bolivian soul. Welcome to CASA CACTUS — fully equipped and personalised for a stay surrounded by natural luxury. 🏊 Swimming pool · 🛜 Starlink · 🌿 Nature · Weekly and monthly DEALS *see below or contact us*. A space to truly unwind. For writing. For slow cooking. To work online and offline. To look at the mountains without haste.

Guest favourite
Flat in Santa Cruz de la Sierra
4.87 out of 5 average rating, 38 reviews

Top Luxury Executive Dept. | Equipetrol

Descubrí el equilibrio perfecto entre comodidad, estilo y ubicación. Este moderno departamento está completamente equipado y ubicado en Equipetrol, la zona más exclusiva de Santa Cruz. Ideal para parejas, viajeros de negocios o escapadas de fin de semana. Disfrutá de increíbles áreas sociales como: 🏊 Piscina 💪 Gimnasio completo 🎯 Sala de juegos 📍 Cerca de los mejores restaurantes, cafés y centros comerciales.

Superhost
Flat in Santa Cruz de la Sierra
4.84 out of 5 average rating, 107 reviews

new and modern apartment

Welcome to your new home in Equipetrol, the best area of Santa Cruz! This new and modern apartment offers you a cozy and comfortable space, ideal for you to enjoy your stay, whether for work or rest. Located in the heart of Equipetrol, you'll be surrounded by everything you need: supermarkets, banks, shops, pharmacies, cafes, restaurants, church and the Ventura Mall. We invite you to enjoy an unforgettable stay.

Guest favourite
Flat in Santa Cruz de la Sierra
5 out of 5 average rating, 25 reviews

Work and relax in Equipetrol, accessible and practical

New studio apartment in the heart of Equipetrol. Ideal for 2 people looking for comfort, style and an unbeatable location. It has an equipped kitchen, a desk to work or study, fast Wi-Fi and a giant Smart TV. The building offers a swimming pool, entertainment room with views, air conditioning and automatic check-in. Perfect for digital nomads, tourists or couples who want to enjoy Santa Cruz to the fullest.

Popular amenities for Santa Cruz holiday rentals