
Holiday rentals in Santee
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Top-rated holiday rentals in Santee
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Lovely Condo w/pool, balcony, and lakeside view!
Relax on the balcony overlooking the pool and lake Marion or go down and relax at the pool, or launch your boat at the boat ramp for the day and go fishing or cruising. There is also a myriad of golf courses near by. For dinner with a great view head over to the other side of the lake to the Lake House bar and grill for adult beverages on the lake with great food. For upscale dining Clark’s restaurant is a good choice. Bike,hike,or cook out over at Santee state park which is only 10 minutes away

Lakefront w/ dock at Mill Creek
Nestled between Santee & Eutawville, Vance is less than an hour from Downtown Charleston. Experience lake life w/ a front row seat to live music, dancing & karaoke at the Mill Creek Marina! Float over to grab a bite or drink at the Barefoot Lakeside Bar & Mill Creek Food & Spirits! Community hosts golf cart parades, Halloween bash, & a spectacular 4th of July fireworks show. Launch your pontoon a few doors down, tie up at your dock & conveniently fuel up at the marina. Campground store on site!

Log home on Lake Marion inlet w/private dock.
Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

Lakeview Leisure-Face to the Sun
At this unique and tranquil getaway, your day can be whiled away on the porch, poolside or in the hot tub. Or pack a cooler and spend the day on Lake Marion. Tie your boat off on the dock and head just down the road to Santee for a round or two at Santee National Golf Club. Located conveniently between Columbia and Historic Charleston you are never out of options to stay as busy as you like. End the day with a cocktail on the back porch, steaks on the grill and a game of pool. Enjoy life!

Heated Indoor Pool on Lake Marion with Dock
Lake Marion Lakefront on a private 2.5 acres. Two houses - 4500 sq. ft. of space, plenty of room for 14! Dock to fish off of or bring your fishing boat. Heated indoor pool and Margaritaville-themed bar. Firepit, pool table, games, and dining table for 14 people. Great spot for Family Gatherings or Friends' Getaway. Golf, fishing, fruit picking, and amazing country food restaurants - 25 min drive. 5% Discount Gov. Employees :) Parties over 14 ppl ++ fees apply, details discussed prior.

Stylish Lakefront Group Getaway Sleeps 8
Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Nanny’s Lake Retreat
3 BR, 2 BA. Located in a quiet, dead end community. Enjoy the lake sounds from the spacious screened in porch. The porch has a swing, rocking chairs, and table with chairs. The den boasts a beautiful gas log fireplace and has two futons and a loveseat. The house is located in a golf cart community on a cove. Sandy beaches are just minutes away depending on the lake levels. Whether you’re looking for a vacation destination or fishing/hunting trip you will love this home.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Cypress shores cottage. Lake Marion Sc
Relax and recharge in this cozy 2BR/1BA home just one row back from Lake Marion. Enjoy an equipped kitchen, bright living area, large streaming TV, and private yard and outdoor seating. Slight water views add to the charm, with marinas, boat landings, and fishing spots just minutes away. Perfect for families, couples, anglers, small groups, or remote workers seeking a peaceful retreat in Eutawville and the Lowcountry.

Beautiful Lake Marion Townhome
Forget your worries in this spacious and serene space. Enjoy the beautiful lake view from our patio. 3 large bedrooms and 3 spacious bathrooms, along with a fully equipped kitchen and comfortable family room make this townhome an outstanding family retreat. 3 golf courses and beautiful Lake Marion make this a fine place to visit on a yearly basis.

The Cypress House
Stunning views and peaceful setting directly on Lake Marion. The entire property will be yours to enjoy for the length of your stay. The property can sleep 14 guests in a total of 9 beds, another 3 on the couches, and still have room left for air mattresses to be utilized if you have a larger group. Please reach out if you have any questions!
Popular amenities for Santee holiday rentals
Other great holiday rentals in Santee

In town cottage

Lake House at Lake Marion

Sunsets on Lake Marion: 2BD Lakefront Luxury Bliss

Sunset Serenity Pool/Swim Spa

Lake House Getaway

Lake Life Living-W/Boat waterfront condo

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

Quiet Waterfront 3 Bedroom on the Lake
Frequently Asked Questions
What are the best places to stay in Santee?
Staying near Lake Marion, in local neighborhoods, or close to community parks is frequently suggested for convenient access to outdoor activities. Waterfront rentals or homes with nature views are popular among groups and families seeking a peaceful retreat.
What are the best things to do in Santee with kids?
Kids can enjoy fishing from piers, playgrounds in area parks, and learning about local wildlife at visitor centers. Boat rentals, gentle trails, and open fields create space for exploration and outdoor play.
What are some of the best things to do in Santee?
Spend time exploring Santee State Park, go fishing or boating on Lake Marion, or enjoy birdwatching in nature reserves. Local golf courses and small-town restaurants add activity options for all interests.
How is the weather in Santee?
Santee has mild winters around 39–60°F (4–16°C) and humid, warm summers near 74–91°F (23–33°C), with the wettest months in midsummer. Spring and fall bring comfortable temperatures and are popular seasons for outdoor activities.
When is the best time to visit Santee?
Late spring and early fall are often recommended for milder weather, with temperatures typically from 63–84°F (17–29°C) in May and 58–78°F (14–26°C) in October. These seasons bring blooming plants and less humidity, making outdoor activities inviting.
What are the best places to visit in Santee?
Santee State Park, Lake Marion, and area wildlife refuges are often recommended for visitors interested in nature and recreation. Local craft shops and smaller museums add cultural depth to your visit.
What are some hiking trails in Santee?
Explore gentle trails in local parks or the Santee State Park, which has routes through pine forests and along the lake’s edge. Boardwalks and shorter nature paths make it welcoming for hikers of various experience levels.
What are some family activities we can do in Santee?
Families can experience fishing and boating on local lakes, play at community parks, or visit nearby wildlife centers for interactive learning. Picnicking areas and gentle trails are frequently suggested for outdoor fun together.
What are some of the best day trip ideas from Santee?
Around Santee, you can explore wildlife refuges, historic small towns, or scenic lakes for boating and fishing. Regional gardens and nature reserves are often recommended for those looking to enjoy local flora and tranquil settings.
Are there any pet friendly accommodations available in Santee?
Santee has a variety of pet-friendly places to stay, especially in areas near lakes and parks. Many local accommodations welcome pets, making it easier for visitors traveling with companion animals.
What are some local tips for visiting Santee?
Locals often encourage exploring nature early in the day to avoid peak heat, and sampling regional seafood or barbecue from family-run spots. Keeping a refillable water bottle handy is practical for outings in the warmer months.
What is Santee known for?
Santee is known for its scenic lakes, freshwater fishing, and outdoor recreation. The area has golf courses, birdwatching sites, and is recognized as a welcoming base for exploring natural and cultural attractions throughout the region.
What are the best hidden gems to explore in Santee?
Santee has serene natural spots like quiet lakeshores, birdwatching areas, and smaller local parks that invite gentle exploration. Discover less-trafficked trails, unique local eateries, or art spaces often appreciated by those seeking a laid-back atmosphere.
What are the best foods to try in Santee?
Regional favorites often include fried catfish, slow-cooked barbecue, and seasonal Southern vegetables. Locally made desserts and sweet tea provide a taste of the area's culinary traditions.
What should I bring for a trip to Santee?
Pack lightweight clothing for warm days, a light jacket for cooler evenings, and comfortable footwear for walks. Bringing sunscreen, bug protection, and a hat is frequently suggested, especially for outdoor exploration or water activities.
What is the nightlife in Santee like?
Nightlife in Santee is mellow, with social settings like local restaurants, bars, and casual gathering spots centered around food and conversation. Some venues host live music or special events on weekends, creating a friendly atmosphere.
What are the most popular events or festivals in Santee?
Santee hosts community festivals during early fall and spring, often centered around local food, live music, and outdoor recreation. Fishing tournaments on Lake Marion are a highlight for those interested in angling competitions.
Are there family friendly vacation rentals in Santee?
Santee has many family-friendly vacation rentals, especially properties around lakes or in quiet neighborhoods. Look for homes with spacious living areas, kitchens, and access to outdoor spaces for relaxed group stays.
Quick stats about holiday rentals in Santee

Total holiday rentals
Explore 30 holiday rentals in Santee

Nightly prices starting at
Santee holiday rentals start at £75 per night before taxes and fees

Verified guest reviews
Over 230 verified reviews to help you choose

Family-friendly holiday rentals
20 properties offer extra space & child-friendly amenities

Holiday rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wifi availability
30 of Santee holiday rentals include wifi access

Popular amenities for guests
Guests love Self check-in, Gym and BBQ grill across Santee rentals

4.7 Average rating
Santee stays receive an average rating of 4.7 out of 5 from guests
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