House holiday rentals in Santee

Find and book unique houses on Airbnb

Top-rated house rentals in Santee

Guests agree: these houses are highly rated for location, cleanliness and more.

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Guest favourite
Home in Kingstree
4.94 out of 5 average rating, 123 reviews

magical 1840s farm house getaway

Centuries old country estate with magical ambiance, art and antiques, beautiful views and wrap around porches. Relax in the hot tub in your own private oasis or gather with friends and family around the fire pit. Multiple bird feeders and grand live oaks, magnolias, fruit trees and a kitchen garden. Chefs kitchen will be stocked with fresh eggs, herbs and seasonal veggies. Sit and sip on the porch while enjoying the views of farmer's field and listing to the moos of the cows. Groups welcome!

Superhost
A dining area features a rustic wooden table surrounded by several chairs, illuminated by a modern pendant light. Large windows provide natural light, offering views of the outdoor scenery, while a cozy living space is seen in the background.
Home in Columbia
4.89 out of 5 average rating, 220 reviews

The Carolina Cottage: Near Ft Jackson, Zoo & 5pts!

Enjoy true Southern hospitality and charm at this 3-bed, 2-bath Columbia home! Whether you’re here to visit family at Fort Jackson or friends at USC, this vacation rental has ALL the essentials you need for a relaxing stay. *Special rates also provided for Military Families waiting on housing. The space: Central Location| Easy Access to Downtown, Five Points & Public Transit (5-10 min) Fort Jackson: 15 Min. Zoo 10 Min MAIN FEATURES: 1 Smart TV ( Master bedroom), 1 TV w/ Roku-living room.

Top guest favourite
A bright living area features a cozy seating arrangement with two plush armchairs and a sectional sofa. A modern coffee table sits in the center, while a large wall-mounted television is positioned above an elegant fireplace. Natural light filters through large windows adorned with light curtains.
Home in Rembert
4.98 out of 5 average rating, 225 reviews

New Home! Only 15 min to Shaw/Sumter. Dog friendly

Built in March 2022 single story home is full of amenities. High speed internet Upgraded cable 15 min to Shaw AFB Conveniently located between Sumter & Camden Premium mattresses Hotel like stay Backyard w/deck Iron/ironing board Vanity table 55 and 65 inch tv's Home office bedroom combo/printer, desk/ monitor and futon (can sleep 2 kids or 1 adult). Laundry room New appliances Kitchen is full of amenities Outdoor lighting Pet friendly! Dog toys, treats, indoor kennel Fenced in dog run

Top guest favourite
A single-story house with a combination of brick and siding exterior is situated in a spacious yard. Surrounding trees provide shade, and the gravel driveway leads to the entrance. The structure features multiple windows, allowing natural light to fill the interior.
Home in Moncks Corner
4.98 out of 5 average rating, 151 reviews

Your home away from home in Pinopolis

Nestled at the end of a quiet cul-de-sac, this house is close to Lake Moultrie & the Cooper River. It’s also very close to popular wedding venues: Somerset Point, Pineland Village, & Old Santee Canal Park. Moncks Corner Recreational Complex, where many tournaments are hosted, is also about 3 miles away. Pinopolis is less than 20 miles from Summerville & the Volvo area, 40 miles from coastal beaches, and just 45 minutes away from Downtown Charleston. It’s a great location for work or play!

Top guest favourite
A charming blue house showcases a welcoming front porch with white railings. Lush greenery surrounds the home, enhancing its inviting facade. The yellow door adds a pop of color, while well-maintained landscaping provides a pleasant entrance.
Home in Sumter
4.97 out of 5 average rating, 139 reviews

The Parkside Retreat

Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

Superhost
The spacious screened-in porch features comfortable seating, a circular table, and ceiling fans. Soft lighting enhances the area, with panoramic views of Lake Marion visible through large screens. Vibrant sunset colors are seen in the sky, reflecting off the water in the background.
Home in Summerton
4.94 out of 5 average rating, 168 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favourite
A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.
Home in Santee
4.96 out of 5 average rating, 166 reviews

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Top guest favourite
The exterior of the villa is shown, featuring a light-colored stucco façade contrasted by large windows. Surrounding landscaped areas include planters with vibrant greenery and flowers. A gravel pathway leads to the entrance, framed by the natural beauty of trees in the background.
Home in Summerville
4.93 out of 5 average rating, 133 reviews

Guest House/Villa

Enjoy your stay at this immaculately designed new build Villa. Located on a family property surrounded by 2 acres of trees, in a quiet rural neighborhood. Lots of privacy, peace and quiet, yet only 5 minutes from restaurants and stores. 15 minutes from Downtown Summerville, 40 minutes from Charleston and various coastal attractions. The villa is separate from main house and has no shared space other than the driveway. NO smoking, No pets. Laundry service available for long stays.

Guest favourite
An outdoor deck is presented with a black wooden dining table surrounded by six chairs. A cozy seating area with red and gray cushions invites relaxation. The fenced yard is visible in the background, surrounded by trees and distant homes.
Home in Santee
4.97 out of 5 average rating, 150 reviews

Pet-Friendly Lake Marion Getaway - Just off I-95!

In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Guest favourite
The exterior of the home is showcased, highlighting a charming façade with a mix of brick and siding. Large windows reflect natural light, and the welcoming porch features seating. A landscaped yard and tall trees provide a serene backdrop, complementing the overall inviting atmosphere.
Home in Summerton
4.83 out of 5 average rating, 110 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Guest favourite
The exterior of the home features a modern architectural design with large windows and a spacious deck. An inviting infinity pool is illuminated, reflecting the colorful sunset. A comfortable outdoor seating area surrounds a fire pit, creating a serene lakeside atmosphere.
Home in Summerton
4.92 out of 5 average rating, 121 reviews

Ultimate Lake Marion Dream Home W/Pool & Swim Spa

Welcome to The White House—a stunning lakefront retreat on Lake Marion. This luxurious home features 4 spacious bedrooms, 3.5 baths, a chef’s kitchen, private dock, gas grill, and HDTVs throughout. Relax in the infinity pool or unwind in the swim spa as you take in the tranquil views. The master suite is a true sanctuary, offering unmatched comfort and elegance. Hosted by Lake Marion Luxury Vacations, this home is your gateway to peace, luxury, and unforgettable memories.

Top guest favourite
A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.
Home in Summerton
4.99 out of 5 average rating, 121 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Popular amenities for house rentals in Santee

Quick stats about house rentals in Santee

  • Nightly prices starting at

    Santee holiday rentals start at £76 per night before taxes and fees

  • Verified guest reviews

    Over 20 verified reviews to help you choose

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Santee rentals

  • 4.9 Average rating

    Santee stays are highly rated by guests – averaging 4.9 out of 5!