Lake house holiday rentals in Santee
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Top-rated lake house rentals in Santee
Guests agree: these lake houses are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for Santee lake house rentals
Waterfront lakehouse rentals
Home in Lexington
4.87 out of 5 average rating, 143 reviewsLake Murray Paradise~2 BR, 1 Bth, Kit/Living area.
18β25 Oct
Home in Elloree
5.0 out of 5 average rating, 40 reviewsLake Front Property (Lake Marion)
18β25 Oct
Home in Manning
4.9 out of 5 average rating, 21 reviewsCozy Church Branch Cabin
16β23 Nov
Home in Summerton
4.98 out of 5 average rating, 53 reviewsUltimate Lake Marion Dream Home W/Pool & Swim Spa
14β21 Feb
Home in Summerton
4.93 out of 5 average rating, 15 reviewsStanley's Lake House
20β27 Nov
Home in Santee
5.0 out of 5 average rating, 13 reviewsSantee Sanctuary ~ Lakefront
16β23 Oct
Home in Summerton
5.0 out of 5 average rating, 6 reviewsLittle Blue Heron
5β12 Oct
Home in Summerton
4.8 out of 5 average rating, 30 reviewsFamily friendly lakefront home with boat ramp
27 Mar β 3 Apr
Pet-friendly lake house rentals
Home in Vance
4.74 out of 5 average rating, 68 reviewsLake Marion Getaway!
20β27 Jul
Home in Elloree
4.92 out of 5 average rating, 25 reviewsLakehouse
17β24 Sept
Home in Summerton
4.8 out of 5 average rating, 15 reviewsSantee/Lizzie's Creek Lakefront
27 Dec β 3 Jan
Home in Bonneau
5.0 out of 5 average rating, 9 reviewsLake House Retreat - Pet Friendly - Private Dock
21β28 Aug
Home in Summerton
5.0 out of 5 average rating, 21 reviewsA Lake Slice of Heaven
9β16 Dec
Home in Summerton
5.0 out of 5 average rating, 11 reviewsCarolina Cottagecore
29 Jul β 5 Aug
Home in Manning
4.88 out of 5 average rating, 34 reviewsJewel on the Lake
14β21 Feb
Home in Ridgeville
5.0 out of 5 average rating, 17 reviewsRiverhouse Retreat on the Edisto River
15β22 Dec
Private lake house rentals
Home in Summerton
4.84 out of 5 average rating, 43 reviewsFlip Flop Inn (Short Walk To Boat Ramp & Kayaks!)
3β10 Apr
Home in Moncks Corner
4.97 out of 5 average rating, 64 reviewsLake Living
30 Mar β 6 Apr
Home in Moncks Corner
4.95 out of 5 average rating, 37 reviewsCozy Little Nook
31 Aug β 7 Sept
Home in Summerton
4.82 out of 5 average rating, 97 reviewsPerfect family vacation retreat at Lake Marion, SC
12β19 Dec
Home in Ridgeway
5.0 out of 5 average rating, 17 reviewsThe Little House
6β13 Jan
Home in Manning
4.87 out of 5 average rating, 84 reviewsLake life on Church Branch
22 Feb β 1 Mar
Home in Chapin
4.97 out of 5 average rating, 63 reviewsLake Murray: Panoramic Views, Kayaks & Hot Tub
20β27 Aug
Home in Camden
5.0 out of 5 average rating, 61 reviewsBest Wateree Sunsets, many amenities w/ king bed!
26 Dec β 2 Jan
Destinations to explore
- Hilton Head IslandΒ Holiday rentals
- Kiawah IslandΒ Holiday rentals
- ColumbiaΒ Holiday rentals
- Folly BeachΒ Holiday rentals
- AugustaΒ Holiday rentals
- Surfside BeachΒ Holiday rentals
- Mount PleasantΒ Holiday rentals
- Hilton HeadΒ Holiday rentals
- BeaufortΒ Holiday rentals
- AtlantaΒ Holiday rentals
- CharlestonΒ Holiday rentals
- Myrtle BeachΒ Holiday rentals
- Yurt RentalsΒ United States
- Yurt RentalsΒ United Kingdom
- Castle RentalsΒ United States
- HouseboatsΒ United States
- Holiday CaravansΒ United Kingdom
- Private Island RentalsΒ United States
- Farm HousesΒ United States
- Farm CottagesΒ United Kingdom
- Cabin RentalsΒ Australia
- Luxury CabinsΒ United Kingdom
- Luxury CabinsΒ United States
- Holiday ChaletsΒ United Kingdom
- Cottage RentalsΒ United States
- Holiday CottagesΒ United Kingdom
- Mansion RentalsΒ United States
- Villa RentalsΒ United Kingdom
- Holiday BungalowsΒ United Kingdom
- Bungalow RentalsΒ United States
- Condo RentalsΒ United States
- Holiday ApartmentsΒ Australia
- Holiday HousesΒ United States
- Holiday HousesΒ United Kingdom
- Private Holiday RentalsΒ United Kingdom
- Big House RentalsΒ United States
- Big CottagesΒ Australia
- Large VillasΒ United Kingdom
- House Rentals with a PoolΒ United States
- Cabin Rentals with a PoolΒ United States
- Villas with a PoolΒ United Kingdom
- Apartments with a Hot TubΒ United States
- Holiday Cottages with a Hot TubΒ United Kingdom
- Beach CabinsΒ United States
- Beach CondosΒ United States
- Beachfront RentalsΒ United States
- Beach HousesΒ United Kingdom
- Beach VillasΒ United Kingdom
- Coastal CottagesΒ United Kingdom
- Pet-Friendly Vacation RentalsΒ United States
- Pet-Friendly Beach RentalsΒ United States
- Pet-Friendly Cabin RentalsΒ United States
- Dog-Friendly CottagesΒ United Kingdom
- Luxury Dog-Friendly CottagesΒ United Kingdom