
Family-friendly holiday rentals in Upstate South Carolina
Find and book unique family-friendly homes on Airbnb
Top-rated family-friendly rentals in Upstate South Carolina
Guests agree: these family-friendly homes are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for Upstate South Carolina family-friendly rentals
Family-friendly home rentals with a hot tub

Amazing Lakefront home with private NEW dock

Ranger Retreat-Chimney Rock Cabin with Waterfalls!

Treehouse at Edenwood|HotTub+Fire Pit|Pet-Friendly

Chic and Peaceful Cottage 5 Min to Main Street

Modern alpaca farm hottub firepit Nice views

Lakefront dock *hot tub* Anderson Clemson King bed

Treetop Getaway w/ Hot Tub • Peaceful retreat

Shipyard 2.0 | HOT TUB, Waterfall, Fire + Hammock!
Family- and pet-friendly home rentals

The Lodge at Pythian Park

Holly Hideaway! 10 Highway miles to Clemson U!

Cozy 2 bedroom, walk to downtown Greenville

Tranquil Farm-Views-Trails-NGU 5 Min-Gville 20 Min

Adjacent to Dawson Park/1 mile from Clemson Univ

Comfy Pelham Rd Gem | 1 Story | Kid & Dog Friendly

Cozy House on the Water with Great Fall Foliage

Perfect 2 bed, remodeled home in quaint Pendleton
Family-friendly home rentals with a pool

College View Cottage & Saltwater Pool

Country Retreat

Shalom Suite with Pool near DT Greer SC

Modern Studio on a Private Horse Farm with a Pool

Greenville With A View!

A quiet place in the country

Renfrow's Retreat

Historic guest house with modern conveniences.
Destinations to explore
- Western North Carolina Holiday rentals
- Nashville Holiday rentals
- Atlanta Holiday rentals
- Myrtle Beach Holiday rentals
- Charleston Holiday rentals
- Gatlinburg Holiday rentals
- Charlotte Holiday rentals
- Hilton Head Island Holiday rentals
- Savannah Holiday rentals
- Pigeon Forge Holiday rentals
- Cape Fear River Holiday rentals
- North Myrtle Beach Holiday rentals
- Rentals with a kayak Upstate South Carolina
- Flat rentals Upstate South Carolina
- Rentals with outdoor seating Upstate South Carolina
- Nature eco lodge rentals Upstate South Carolina
- Treehouse rentals Upstate South Carolina
- Holiday home rentals Upstate South Carolina
- Beachfront rentals Upstate South Carolina
- Villa rentals Upstate South Carolina
- Private suite rentals Upstate South Carolina
- Waterfront rentals Upstate South Carolina
- Rentals with a washing machine and dryer Upstate South Carolina
- Chalet rentals Upstate South Carolina
- Rentals with a sauna Upstate South Carolina
- Rentals with a cinema Upstate South Carolina
- Bed and breakfasts Upstate South Carolina
- Farm stay rentals Upstate South Carolina
- Rentals with a patio Upstate South Carolina
- Smoking-friendly rentals Upstate South Carolina
- Rentals with an EV charger Upstate South Carolina
- Rentals with a fireplace Upstate South Carolina
- Rentals with breakfast Upstate South Carolina
- Fitness-friendly rentals Upstate South Carolina
- Tiny house rentals Upstate South Carolina
- Cabin rentals Upstate South Carolina
- Loft rentals Upstate South Carolina
- Rentals with a firepit Upstate South Carolina
- Resort rentals Upstate South Carolina
- Cottage rentals Upstate South Carolina
- House rentals Upstate South Carolina
- Rentals with an accessible-height toilet Upstate South Carolina
- Hotel rentals Upstate South Carolina
- Pet-friendly rentals Upstate South Carolina
- Rentals with pools Upstate South Carolina
- Rentals with a hot tub Upstate South Carolina
- Barn rentals Upstate South Carolina
- Townhouse rentals Upstate South Carolina
- Serviced apartment rentals Upstate South Carolina
- Guest house rentals Upstate South Carolina
- Apartment rentals Upstate South Carolina
- Rentals with lake access Upstate South Carolina
- Rentals with beach access Upstate South Carolina
- Family-friendly rentals South Carolina
- Family-friendly rentals United States
- Blue Ridge Parkway
- Gorges State Park
- Chimney Rock State Park
- Table Rock State Park
- The North Carolina Arboretum
- Tryon International Equestrian Center
- Lake Lure Beach and Water Park
- Ski Sapphire Valley
- Wade Hampton Golf Club
- Jump Off Rock
- Victoria Valley Vineyards
- Discovery Island
- Carl Sandburg Home National Historic Site
- Haas Family Golf
- Russian Chapel Hills Winery
- Burntshirt Vineyards
- Saint Paul Mountain Vineyards
- City Scape Winery
- Wellborn Winery
- Overmountain Vineyards