
Guest house holiday rentals in Upstate South Carolina
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Top-rated guest house rentals in Upstate South Carolina
Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

Scenic Loft in the Woods
Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!
4.97 out of 5 average rating, 381 reviews
Historic 19th Century Cabin/Guest House
This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.
4.93 out of 5 average rating, 754 reviews
Mountain Cabin on Creek at Jocassee Gorge.
Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.
4.91 out of 5 average rating, 453 reviews
The Cottage at Old Oaks Farm
Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.
4.99 out of 5 average rating, 468 reviews
Wolf Lake Escape - lake & mountain retreat
Beautiful secluded setting on Wolf Lake. Private studio apartment with full kitchen and bath. Stunning lake view and full lake access with use of kayaks, canoe and dock in the adjacent cove. Private patio with fire pit and grill. Paradise Falls trailhead 1 mile away. Close to Panthertown Valley Backcountry Area with multiple trails and waterfalls. 45 minutes from Brevard, Sylva and Cashiers, NC. Easy drive to Asheville and Biltmore House. Onsite parking. Well behaved pets welcome
4.99 out of 5 average rating, 273 reviews
Gorgeous Downtown Studio & Dog Friendly!
This has changed to a minimum of a 3 month rental! Message me if you're trying to book and your dates aren't showing available! This location is unmatched. Steps from Falls Park which includes one of the most majestic waterfalls, green space and Swamp Rabbit Trail for all your running/walking and biking needs. Directly across the street from the Greenville Drive baseball stadium. One block from all the finest restaurants, shopping and best attractions downtown offers.
4.95 out of 5 average rating, 258 reviews
The Lodge at Pythian Park
Situated in a 3+ acre gated compound surrounded on three sides by Fairforest Creek, our guest house feels like a mountain hideaway yet it's only a 3 minute drive to downtown Spartanburg. Enjoy the private patio overlooking the creek to relax or prepare a meal on the gas grill. Dogs are welcome, and we have 2 very social dogs that you will probably encounter during your stay. There's ample parking for vehicles and room to roam and enjoy the park-like setting.
5.0 out of 5 average rating, 151 reviews
Greenville With A View!
ONLY 10-15 MINUTE DRIVE TO THE HEART OF BEAUTIFUL DOWNTOWN GREENVILLE! We are only 11 miles to GSP Airport; 6 miles to Greenville Downtown Airport; and 10 minutes to the Swamp Rabbit Trail. We are minutes to Furman University, Bob Jones University, North Greenville University and Clemson University is only 45 minutes away. We are tucked away open top of Paris Mountain. If you want to bike, hike, paddle, swim, boat or just soak it all in, start here!
4.98 out of 5 average rating, 291 reviews
The Dwelling Place: Just a mile from downtown TR
The Dwelling Place was created for guests to enjoy Travelers Rest and the beautiful surrounding areas. It is a studio apartment above a detached garage with a private entrance and driveway. We are a one minute walk from the Swamp Rabbit Trail, a 1.2 mile walk from the idyllic downtown Travelers Rest, 20 min. from Greenville, 8 min. from Furman, 15 min. from North Greenville University, and close to numerous hikes, waterfalls, and outdoor adventures!
4.99 out of 5 average rating, 121 reviews
Home on the farm
aprox. 4 miles to Erskine College and aprox. 15 miles to Greenwood sc. You’ll love the farm setting, good for couples, solo adventurers, business travelers, families (with kids), and furry friends (pets).we are aprox. 11 miles from Abbeville SC birth place of the confederacy. aprox. 60 miles to Augusta GA the masters golf tour. aprox. 40 miles to CLEMSON U. The Diamond Hill Mine in Abbeville is about 17 miles from here.
4.99 out of 5 average rating, 411 reviews
Shou-Sugi-Ban Retreat on the Saluda River
The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.
4.97 out of 5 average rating, 146 reviews
1 bedroom lake front apartment with gorgeous views
Relax in a cozy apartment on Lake Hartwell. The apartment is located in a secluded peaceful, cove near downtown Hartwell and is in close proximity to hiking and numerous outdoor activities in the hill country of Georgia and South Carolina. The apartment sleeps 2 comfortably and is fully equipped with a kitchen and a private laundry facility.
4.98 out of 5 average rating, 183 reviewsPopular amenities for guest house rentals in Upstate South Carolina
Family-friendly guest house rentals

Private-Lake getaway-7 mile view from dock
4.94 out of 5 average rating, 219 reviews
Campus Cottage
4.98 out of 5 average rating, 123 reviews
Windcrest Loft- charming retreat near the river.
4.97 out of 5 average rating, 368 reviews
Elfwing Carriage House
4.98 out of 5 average rating, 228 reviews
Warrior Hall Cottage 1
4.97 out of 5 average rating, 169 reviews
Cozy Rustic Lakefront Cabin
4.97 out of 5 average rating, 186 reviews
1-bedroom guesthouse in Abbeville, SC
4.96 out of 5 average rating, 185 reviews
Lit'l Bit O' Heaven- Rocky Top Lodge
4.99 out of 5 average rating, 196 reviewsGuest house rentals with a patio

Blessed Haven - king bed guest house
4.94 out of 5 average rating, 132 reviews
Modern guesthouse in downtown TR
4.95 out of 5 average rating, 151 reviews
Sally's Cottage
5.0 out of 5 average rating, 197 reviews
Cozy guest cottage at The Black Walnut Chateau
4.98 out of 5 average rating, 317 reviews
Starswept Studio–Near GSMNP, BRP, walk to Joey’s.
5.0 out of 5 average rating, 495 reviews
Fletcher NC Getaway
4.96 out of 5 average rating, 100 reviews
Carriage House in the Woods
5.0 out of 5 average rating, 110 reviews
Country-Clubhouse Tiny Home. Close to downtown!
4.93 out of 5 average rating, 123 reviewsGuest house rentals with a washing machine and dryer

MeadowHill Guesthouse - Mountain view-3 mi to town
5.0 out of 5 average rating, 123 reviews
Modern Carriage House
4.97 out of 5 average rating, 207 reviews
Upscale cottage in Downtown Fountain Inn
4.98 out of 5 average rating, 134 reviews
Carolina Cottage Guest House
4.98 out of 5 average rating, 327 reviews
Farmhouse by the lake - Private guest house
4.87 out of 5 average rating, 218 reviews
Love Shack
5.0 out of 5 average rating, 205 reviews
The Guest House By The River
5.0 out of 5 average rating, 113 reviews
Lake front Lake Murray in the Heart of Lexington
4.97 out of 5 average rating, 176 reviewsDestinations to explore
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- Clemson University
- Blue Ridge Parkway
- Tryon International Equestrian Center
- Table Rock State Park
- The North Carolina Arboretum
- Chimney Rock State Park
- Gorges State Park
- Devils Fork State Park
- Lake Lure Beach and Water Park
- DuPont State Forest
- Bon Secours Wellness Arena
- Saint Paul Mountain Vineyards
- Jump Off Rock
- Fred W Symmes Chapel
- Falls Park On The Reedy
- Jones Gap State Park
- Fluor Field at the West End
- Peace Center
- Whitewater Falls
- Carl Sandburg Home National Historic Site
- Overmountain Vineyards
- Oconee State Park
- Furman University
- Memorial Stadium, Clemson
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