Hotels in Upstate South Carolina

Find and book unique hotels on Airbnb

Top-rated hotels in Upstate South Carolina

Guests agree: these hotels are highly rated for location, cleanliness and more.

%{current} / %{total}1 / 1
Guest favourite
A cozy interior space is showcased with natural wood paneling. A spiral staircase leads to an upper level. A modern kitchen with bar seating features a sleek countertop and contemporary appliances. Soft seating is provided by a light-colored sofa, inviting relaxation.
Hotel room in Cashiers
4.96 out of 5 average rating, 119 reviews

Log Suite at our Boutique Bed & Brewery

Our Two-Story log suites are the perfect basecamp for couples and families alike. They offer two bedrooms with two spacious bathrooms, along with a small kitchen, equipped with induction cook top and refrigerator. Great for extended weekends or a quick trip to enjoy the beauty of Cashiers, North Carolina. Be sure to take a quick hike over to our on-site brewery, Whiteside Brewing Co., and enjoy the great food and drink selection they have to offer. This suite is sure to cure what “ales” you! ;)

Guest favourite
Two glasses of red wine sit on a wooden table, accompanied by a plate of snacks. In the background, a cozy gathering occurs around a firepit, with people enjoying food and each other's company, surrounded by a warm ambiance.
Hotel room in Highlands
4.85 out of 5 average rating, 13 reviews

Outpost Inn Highlands

The Petite is our 170 SF Queen hotel room with all of the bells and whistles of larger rooms but in a cozier footprint- luxury Queen mattress, Italian linens, vintage Appalachian textiles, Pendleton Blankets, coffeemaker, minibar with NC goodies, minifridge, luxury bathroom with robe, luxury toiletries and amazing walk in shower with the best water pressure. Please note this Room has since been painted Hague Blue by Farrow and Ball (pics on the way!). Outside your door is our newest firepit!

Superhost
An outdoor heated pool is surrounded by lush green mountains and trees. Bright green lounge chairs sit beside the pool, providing a space for relaxation. The sky is mostly clear with scattered clouds, enhancing the serene atmosphere of the setting.
Hotel room in Ashville
4.81 out of 5 average rating, 57 reviews

Asheville Escape | Free Parking & Pet-Friendly

Experience Asheville’s charm at Holiday Inn Asheville East-Blue Ridge Parkway, a pet-friendly mountain lodge hotel perfectly situated near Biltmore Estate and the Blue Ridge Parkway. Enjoy an on-site dining at Woodfire Grille & Bar and modern amenities like free WiFi, EV chargers, and a fitness center. Explore attractions, hiking trails, and scenic views, all just minutes away. Perfect for families, pets, and tour groups, offering comfort and convenience in a prime location.

Guest favourite
Hotel room in Clayton
5 out of 5 average rating, 7 reviews

King Room at Bridge Creek Inn

Settle into comfort in our Standard King Room at Bridge Creek Inn—perfect for solo travelers or couples. This stylish room features a plush king bed, smart TV, mini-fridge, and a modern bathroom with a walk-in shower. Natural light fills the space, creating a warm and relaxing atmosphere. Enjoy high-speed Wi-Fi and a cozy layout ideal for work or rest. Don’t miss Vandiver, our onsite restaurant and bar, serving up Southern-inspired cuisine and craft cocktails daily.

The living area features a stone fireplace and a wall-mounted television. Two armchairs and a sofa are arranged around a wooden coffee table on a patterned rug. Large glass doors open to a balcony, allowing natural light to fill the space.
Hotel room in Ashville
4.72 out of 5 average rating, 745 reviews

2BD/2BA Condo Near Biltmore Estate and Downtown

Nestled in the historic Kenilworth neighborhood, our two-bed/two bath in one of Asheville's premier condo hotels is minutes from Biltmore Estate & Downtown Asheville. Amenities including a fitness facility; free WiFi; spa packages & in-room treatments by appointment; on-site security; & 24/7 concierge service. Most studios are equipped with a washer/dryer. Our location makes it the perfect "home base" to explore the art, history, nature, & culture of Asheville.

Superhost
A spacious bedroom features a king-sized bed with an ornate wooden headboard and matching posts. A lighted ceiling fan circulates air, while a television is mounted on the wall. Natural light streams through the plantation shutters, enhancing the neutral-toned walls.
Hotel room in Lake Lure
5 out of 5 average rating, 3 reviews

Swayze Suite at Lake Lure Inn

Experience vintage elegance and modern comfort in the Swayze Suite at The Lake Lure Inn and Spa. This luxurious retreat features a king-sized bed, spa-inspired bathroom, and a cozy living area with old Hollywood charm. Guests enjoy access to the inn’s pool, on-site dining, and spa. Explore Lake Lure's scenic beauty and iconic "Dirty Dancing" locations. Perfect for romance or relaxation, this suite offers an unforgettable getaway. Book now for timeless memories!

Guest favourite
Hotel room in Ashville
4.97 out of 5 average rating, 221 reviews

King room with City View at Kimpton!

Stay steps from Asheville’s buzzing breweries, indie art galleries, and live music at Kimpton Hotel Arras. Your room blends boutique flair with luxe linens, spa-inspired bathrooms, and city or Blue Ridge Mountain views. Grab a cocktail at the lobby bar, hop on a complimentary bike to explore downtown, or soak up Asheville’s creative soul with your pup in tow. Warm Southern vibes, walkable adventures, and boutique perks make this the ultimate Asheville escape.

Hotel room in Greenville
4.73 out of 5 average rating, 143 reviews

Near GSP Airport | Bar & Dining + Shuttle

Experience the best of Greenville at our conveniently located Cambria Hotel, just off I-85 and I-385. We’re minutes from downtown dining, shops at Greenridge, and local favorites like Frankie's Fun Park and Roper Mountain Science Center. Enjoy free WiFi, an outdoor pool, airport shuttle service, and on-site dining at Woodside Grill. Greenville-Spartanburg Airport is just 8 miles away with complimentary shuttle access.

Superhost
A well-appointed room featuring two spacious queen beds with crisp white linens. Soft lighting from wall-mounted sconces provides illumination, while neutral walls and dark wood accents create a calm ambiance. A nightstand is positioned between the beds.
Hotel room in Hendersonville
4.71 out of 5 average rating, 56 reviews

Kanuga Lake Inn-Two Queen Shared Balcony

Traditional hotel accommodation that includes two queen beds, private bathroom and air conditioning. These rooms feature a shared balcony with the adjacent room that overlooks into a courtyard area or a parking lot. Our hotel rooms do not have a view of the lake. Please note there is not a TV in the room. There is free parking that includes designated Handicapped Parking spots.

Superhost
Hotel room in Fort Mill
4.81 out of 5 average rating, 258 reviews

Minutes to Charlotte + Pool. Bar & Free Parking

Experience small-town charm just 20 miles from Uptown Charlotte at Cambria Hotel Fort Mill. Located near I-77, we’re just 2 miles from Baxter Town Center and 10 minutes from Carowinds. Enjoy modern amenities including a seasonal outdoor pool, 24/7 fitness center, on-site dining, and tech-forward rooms with Bluetooth mirrors, perfect for exploring Fort Mill and greater Charlotte.

Guest favourite
A spacious room features a large bed with soft bedding and a decorative pillow. A comfortable sofa is positioned in front of the bed. A dining area with a round table and chairs is visible, along with a kitchenette in the background.
Hotel room in Clemson
5 out of 5 average rating, 57 reviews

The Abernathy

The Abernathy is located one block from The Rock and offers guests large rooms with 445 sq. ft. to stretch out and enjoy their stay in Clemson. Bicycles are available for guests to take on a leisurely pedal through Clemson's campus at their own pace. There is also an on-site bar to enjoy after a long day of exploring.

Guest favourite
Hotel room in Waynesville
4.88 out of 5 average rating, 88 reviews

Updated Stylish Stone Retreat for Couples Getaway

Relax into your private room at WildRest, with shared outdoor spaces designed for slow mornings and quiet connection, perfect for couples, nature lovers, and weekenders drifting between Asheville and Waynesville in search of a more intentional stay.

Popular amenities for Upstate South Carolina hotels

Destinations to explore