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House holiday rentals in Panama City

Find and book unique houses on Airbnb

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness and more.

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Guest favourite
The exterior of a two-story residence is shown, featuring a classic design with a stone façade and wooden accents. Lush greenery surrounds the entrance, where steps lead to the upper level. Two friendly dogs can be seen in the foreground, adding a welcoming touch to the scene.
Home in Panama City
4.87 out of 5 average rating, 86 reviews

Central|Confort|surrounded by nature|Wifi|parking

Conectar con la ciudad y la maravillosa naturaleza al mismo tiempo. Descansar en una hamaca en el balcón lo hace único. Te quedará genial si deseas visitarnos de placer, trabajo (WiFi de alta velocidad); en familia o en grupos de amigos. Casa de la Antigua Zona del Canal, Primer Alto; desde aquí para explorar lugares turísticos y restaurantes. (Cerca Terminal de Buses, Metro Tren, Albrook Mall, parque Metropolitano, Aeropuerto Marcos Gelabert, Casco Antiguo, Coast Way de Amador, Canal de 🇵🇦)

Guest favourite
An inviting living area features a grey reclining chair and a light wooden coffee table with decorative plants. In the background, a dining table set for four is visible, along with a stone accent wall that adds texture. Natural light fills the room through a nearby window.
Home in Panamá
4.95 out of 5 average rating, 38 reviews

Cantabria House - 10 minutes from the Airport

Spacious and comfortable home just 10 minutes from Tocumen Airport and only 200 meters from the Metro. Perfect for families, groups, or business trips. Fast 500 Mbps Wi-Fi, 3 bedrooms, 2 full bathrooms, fully equipped kitchen, air conditioning throughout the house, cable TV, patio with outdoor furniture, private parking, and self check-in. Long layover, family trip, or work in the city? This home has it all: comfort, location, and privacy. Book now and feel at home from the very first moment!

Guest favourite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
5 out of 5 average rating, 50 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Guest favourite
A spacious bed is featured with two decorative pillows against a textured headboard. Soft natural light streams through partially covered windows, while a minimalist side table and shelf are positioned nearby, providing additional storage and a clean aesthetic.
Home in Panamá
4.74 out of 5 average rating, 23 reviews

aparta-estudio-cocina-wifi6-tv-confort-tranquilo

bienvenidos a mi hogar, diseñado especialmente para ti! te cuento que nuestro aparta-estudio cuestan con su baño privado,muy cómodo,cama matrimonial super confortable,con su aire acondicionado,cocina,utensilios, nevera,cuenta con cerradura digital para mayor seguridad. 🙂 si vienes por trabajo tenemos la mesa ideal para que puedas trabajar cómodo,el lugar es céntrico,muy tranquilo y queda a pasos de costa del Este.. (centro de negocios y turístico).si te interesa se alquila carro!

Guest favourite
The façade of Casa Arango features a two-story colonial design with wooden doors and large, multi-paned windows. A charming balcony extends across the front, adorned with potted plants. The entrance is marked by a solid wood door, complemented by stone steps and decorative lanterns.
Home in Panama City
4.93 out of 5 average rating, 14 reviews

A Charming Colonial House in Casco Antiguo

Welcome to Casa Arango, a beautifully restored 19th-century gem in the heart of Casco Antiguo. Located on a quiet, picturesque street, this colonial house blends historic charm with modern comforts. Casa Arango offers three elegant rooms with private bathrooms, a front balcony, and a spacious patio with a barbecue and private bar. Perfect for families or groups of up to 8, the property also includes two private parking spaces—an exclusive luxury in the area.

Superhost
Home in Panamá
4.83 out of 5 average rating, 41 reviews

apartamento Lilia Airport 2

Bienvenidos a nuestro acogedor apartamento ideal para dos a tres personas! con un baño y una cocina equipada. Aunque solo tiene una ventana frontal, el apartamento está perfectamente climatizado con aire acondicionado y cuenta con ventiladores en ambos dormitorios. Disfrutarás de la tranquilidad y seguridad que ofrece nuestro vecindario, permitiéndote relajarte y descansar plenamente durante tu estadía. ¡Te esperamos para una experiencia inolvidable!

Top guest favourite
The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.
Home in Panamá
4.93 out of 5 average rating, 375 reviews

Estudio Privado a 10 Min del Aeropuerto !

Apartamento Entero a 10 MINUTOS del Aeropuerto! El apartamento está completamente amueblado incluyendo electrodomésticos y artículos de cocina , productos de aseo , sala comedor ,mesa de trabajo y demás. A sólo minutos caminando de la Estacion de METRO SAN ANTONIO, restaurantes, centros comerciales,lavanderias,supermercados y farmacias. Ofrecemos Tours a San Blas para que aproveches al maximo tu viaje. Nuestra casa es Tu casa en Panamá 🇵🇦

Top guest favourite
A spacious living and dining area is depicted, featuring a blue sectional sofa with yellow accent pillows. A glass dining table with yellow placemats and black chairs is shown. Natural light enters through windows, revealing a glimpse of greenery outside.
Home in Panama City
4.81 out of 5 average rating, 109 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Guest favourite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.93 out of 5 average rating, 128 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Superhost
A modern kitchen is featured with sleek granite countertops and stainless steel appliances. Framed wall art adds a touch of style. A small dining table is visible in the background, alongside window blinds that filter natural light.
Home in San Miguelito
4.88 out of 5 average rating, 17 reviews

Casa Santa by SS • 3BR Perfect Stay Near City

This memorable place is anything but ordinary. This stylish place is perfect for group of persons or family trips. Conveniently located next to shopping malls and supermarkets you’re literally minutes from the train station and just minutes to the city. San Antonio is a safe place for families. Enjoy a cozy silent place with everything you can need for your stay.

Guest favourite
The interior showcases a cozy seating area with a brown sofa and two clear chairs around a glass table. A spacious bed with warm bedding is positioned against the wall. Natural light enters through large windows adorned with soft curtains, highlighting decorative shelves and artwork.
Home in Panamá
4.92 out of 5 average rating, 158 reviews

Golden Space | By Paradox

PRIVATE APARTMENT IN PANAMA CITY, CLOSE TO CASCO VIEJO. If you're looking to get submerged into real Panama and live among the real locals. This is the right place to be. For More Info or visual content, follow us on IG as Paradox Experience and visit our Virtual Showcase with the link in our IG BIO. More than a regular stay, we are an experience.

Guest favourite
An exterior view of a charming house features a white door with decorative grillwork. A well-lit entryway is highlighted by a window with multiple panes, illuminating the area. Lush greenery frames the entrance, with colorful flowers adding a touch of vibrancy.
Home in Panamá
4.93 out of 5 average rating, 15 reviews

A little House in Panama City

Your family will be close to everything when you stay at this centrally-located place. This is a gorgeous little house, for taking a rest when you are in Panamá, in the center of everything, you are close to the metro station and close to the different amenities and attractions of Panamá City.

Popular amenities for house rentals in Panama City

Quick stats about house rentals in Panama City

  • Total rentals

    470 properties

  • Nightly prices starting at

    £7 before taxes and fees

  • Total number of reviews

    7.3K reviews

  • Family-friendly rentals

    180 properties are a good fit for families

  • Pet-friendly rentals

    160 properties allow pets

  • Rentals with a pool

    90 properties have a pool

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City
  5. House rentals