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Hotel holiday rentals in Panama City

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Panama City

Guests agree: these hotel rentals are highly rated for location, cleanliness and more.

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Casa particular in Panamá
New place to stay

Historic Apartment - Balcony in Old Town

🇵🇦Vive la esencia del Casco Antiguo en este apartamento único, diseñado por el arquitecto Sebastián Paniza, conocido por su labor en restauración del Casco Histórico. Sus techos altos, ventanales coloniales y barandales de hierro forjado combinan historia y confort moderno. 🌿 Desde el balcón disfruta calles empedradas y fachadas coloniales. La sala con lámpara tipo candelabro, entrepiso abierto y cocina funcional es ideal para quienes valoran diseño, cultura y ubicación privilegiada.

A three-level villa is shown, featuring a bright yellow exterior with blue roofing. Large windows allow natural light to fill the space. Surrounded by lush greenery and tropical plants, a driveway with a vehicle is visible, enhancing the property’s inviting atmosphere.
Casa particular in Panamá

La Husseyenda- Birdwatcher Haven

A Birdwatcher’s and Jungle Paradise nestled in Los Altos de Cerro Azul, this 3-level villa offers breathtaking Lake Alajuela views, stunning sunsets, and endless birdwatching opportunities! Spot hummingbirds, tanagers & toucans from the terrace while howler monkeys call in the distance. Family & pet-friendly with a fenced garden, spacious BBQ, & a fully equipped kitchen. Relax in nature’s paradise—your jungle escape awaits! Make some memories at this unique and family-friendly place.

Guest favourite
A cozy hotel room is showcased with a spacious bed dressed in white linens and a red throw blanket. A wooden desk with two cups and a remote is positioned beside the bed. A soft lamp and a wall-mounted TV complete the inviting atmosphere.
Hotel room in El Cangrejo
4.73 out of 5 average rating, 33 reviews

Hotel room #3 one block from the Metro.

Disfruta de acceso ràpido a los destinos más populares de Ciudad de Panamà, centros comerciales, restaurantes, y áreas turísticas. Cuarto de hotel con baño privado, aire acondicionado, cable TV, recepciòn con 24 horas de servicio y estacionamientos sujetos a disponibilidad. Cerca de restaurantes y casinos. A una cuadra de la estaciòn del Metro que lo lleva en 10 minutos a Albrook Mall, el Centro Comercial más grande de Panamà.

Private room in Santa Cruz De Chinina
5 out of 5 average rating, 4 reviews

Comfort and privacy Casa Orquídea

Casa Orquídea es un Hermoso Residencial ubicado en el corazón de la ciudad de Panamá. Bienvenido a la joya de Paitilla rodeada de edificios, mar, y de una hermosa vegetación, esta casa es el secreto mejor guardado en una de las zonas más exclusivas de la ciudad, con espacios seguros para caminar. Este es el paraíso urbano para los amantes de la naturaleza. ¡Desconéctate y relájate en medio de la ciudad!

Guest favourite
A cozy sleeping area features a plush bed with a light-colored quilt and dotted pillows. A bedside table holds a small lamp, providing soft lighting. The wall is adorned with a unique decorative panel, and a ceiling fan offers comfort.
Private room in Panamá
4.83 out of 5 average rating, 23 reviews

Desk & Dream Room in flat for work and rest

Disfruta de la comodidad de este alojamiento tranquilo y céntrico en el corazón de San Francisco, tiene escritorio dentro de la habitación para trabajar o estudiar en un ambiente relax, con las demás comodidades incluyendo televisor led HD de 32" Justo en la calle de al lado está el super mercado, farmacia al frente, restaurantes, tiendas de chinitos, panaderías, paradas del metro bus cercanas.

An outdoor terrace features several lounge chairs and tables shaded by large umbrellas. A swimming pool extends along one side, with a backdrop of modern high-rise buildings under a partly cloudy sky. Lush greenery is present in planters, adding a touch of nature.
Hotel room in Marbella
4.63 out of 5 average rating, 8 reviews

In the heart of the city.

Hotel Mio Panama we are a 4 star hotel located in Panama City, in the heart of the financial area. Our main goal is to meet any needs of the client, offering the best services to ensure a comfortable and peaceful stay. Among our modern facilities, you will find a pool, spacious and comfortable rooms, gym, meeting rooms, and rooftop. If you like to travel with your pet, we are pet friendly.

An outdoor swimming pool is situated on a rooftop terrace, surrounded by lounge chairs. The skyline of Panama City serves as a backdrop, illuminated by soft twilight hues. Palm plants are placed in decorative pots along the pool's edge, enhancing the space.
Hotel room in Obarrio
5 out of 5 average rating, 3 reviews

Marinn Place | Deluxe King | Cozy Work & Rest

Located in Panama City’s upscale Financial District near Via España and Bella Vista, Marinn Place offers modern comfort, a rooftop pool, and free valet parking in a vibrant urban setting. The spacious Deluxe Double features two plush queen beds, a separate living/sleeping area with a sofa bed, a work desk, and a walk-in glass shower—perfect for families or professionals.

Guest favourite
A close-up view of vibrant purple bougainvillea flowers is presented alongside a well-maintained pathway, leading to a charming building with arched windows and a wooden front door. Green foliage frames the entrance, enhancing the welcoming atmosphere.
Hotel room in Panamá
4.86 out of 5 average rating, 44 reviews

Private rooms Sofia's B&B Hostal Boutique

Boutique hostel-style accommodation, we have 7 comfortable private rooms with bathroom, for a total capacity of 18 guests. The rate shown by Airbnb for your reservation is for 2 guests per room, i.e., guests will need to share beds and/or rooms. If you require a special room layout for your group, please contact the host first, as the rate may vary.

Guest favourite
Large green doors open to a charming balcony, revealing a view of a red-tiled roof and a small table with two chairs. A soft sofa is positioned nearby, complementing the inviting atmosphere of the space.
Hotel room in Panamá
4.85 out of 5 average rating, 108 reviews

Corcho rooms #2 - king room with balconies

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant an serviced guest rooms upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the building around are restored and the neighborhood is safe.

Guest favourite
A spacious private room features a comfortable bed covered with a soft blanket and neatly arranged towels. Two windows allow natural light to enter, while a ceiling fan provides airflow. A closet offers storage, and the neutral colors create a calming environment.
Private room in Marbella
4.9 out of 5 average rating, 59 reviews

Spacious and lovely room meters from the sea - Ztz

Lovely spacious private room with a new brand bed, with great lightning and a workspace inside it. Shared bathroom. Shared kitchen with your private kitchenware and utensils needed to cook. Shared laundry room, with a washing machine

A sleeping area features a spacious bed with a neutral-toned cover and a dark blue blanket folded at the foot. Simple wooden nightstands are mounted on either side, each equipped with bedside lighting. Soft natural light filters through a sheer curtain over a window.
Hotel room in Panamá
4.68 out of 5 average rating, 82 reviews

Your second home in Panama.

Our rooms are located in a privileged area in the heart of the city's financial and banking sector. We are two blocks away, two stations from the Metro transport system. 15 minutes from some Shopping Centers.

Superhost
Hotel room in Marbella

The Corner Suite #110 | La Résidence Panamá

Contemporary comfort for the modern traveler. This 35–37 m² suite features a king-size bed, full kitchen, washer/dryer, Coffe machine, and A/C — designed with thoughtful touches to make you feel at home.

Popular amenities for hotel rentals in Panama City

Quick stats about hotel rentals in Panama City

  • Total rentals

    130 properties

  • Nightly prices starting at

    £7 before taxes and fees

  • Total number of reviews

    3.6K reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    20 properties allow pets

  • Rentals with a pool

    30 properties have a pool

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City
  5. Hotel rentals