
Villa holiday rentals in Panama City
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Top-rated villa rentals in Panama City
Guests agree: these villas are highly rated for location, cleanliness and more.

Spacious Mountain Getaway in Paradise Cloud Forest
Private Villa located at Chagres National Park; a rainforest reserve only 30 minutes away from the airport and 50 minutes from Panama City. At 1,007 meters altitude, you will enjoy the perfect climate, bird watching, beautiful river walks, waterfalls, and many hiking trails full of wildlife, enjoy our mountain's pure air or simply relax in Nature. Bring the whole family to this great place with lots of room for fun. Bring your pets our land is completely fenced, they can run free in a vast space

Summit View Guest House Cerro Azul Panama
We have two properties in one estate in Cerro Azul. A guest house as well as an apartment. We are delighted to be able to welcome your entire family, including grandma and grandpa to our slice of paradise. Your experience here promises to be a perfect blend of relaxation, adventure, and breathtaking beauty. Our property boasts a sprawling lower balcony with unparalleled vistas. The guest house and apartment, along with the undercover terrace, pool and spa, are available for your enjoyment.

Breathtaking Views Mansion w/King Beds
Book your next thrilling Panama City vacation at our dreamy 11,500 sq. foot multi-story family mansion, superbly located on a hilltop high above the metropolis in this affluent neighborhood. Ideal for longer stays. Discover the vibrant buzz of Cinta Costera or explore the UNESCO world heritage sites at Casco Viejo – all under 5 km away from your doorstep. Enjoy a refreshing dip into the swimming pool and admire the sublime views of the Panama City Skyline from our unique roof terrace.

Casa AcoModo @Casco Viejo – Remodeled 6BR & Pool
Welcome to Casa AcoModo, a fully renovated luxury home in the heart of Casco Viejo. This 420 sqm residence features 6 bedrooms, 6 bathrooms, spacious living areas, a private pool, and a brand-new rooftop with jacuzzi and BBQ. Enjoy a panoramic corner balcony, a primary bedroom with bathtub, daily housekeeping, AcoModoTV with 5,000+ channels, and access to AcoWorking Gallery with luggage storage and workspaces. Prime location steps from everything, ideal for families and groups.

Beautiful House in Panama w/ King Beds + Pool
Beautiful home in Punta Paitilla featuring 6 bedrooms, 5.5 bathrooms, and 8 beds, comfortably accommodating up to 16 guests. Enjoy a private pool, in-home gym, and spacious, modern living areas designed for families, groups, or business travelers. The layout offers both privacy and comfort across two levels. Located in one of Panama City’s most exclusive neighborhoods, just minutes from restaurants, shopping centers, supermarkets, and the Cinta Costera.

La Semilla | Jungle Mansion | Panama City
Just one hour from Panama City, you will find La Semilla | Jungle Mansion in the Cerro Azul cloud forest, bordering the Chagres National Park. La Semilla is a perfect private escape to relax or party in serene privacy. Boasting 7 luxurious king bedrooms suites all with A/C, flatscreens, wi-fi, en suite bathrooms and memory-foam mattresses. Amenities: bar, chef/restaurant, jacuzzi, billiards, movie lounge, and pool.

Villa Helena Studio 1 Apt. Cerro Azul
One bedroom cottage with private kitchen and bathroom in a peaceful compound with shared pool. Internet and free parking available. Laundry facilities available for longer stays. Cook your own meals, or have me cook some authentic Caribbean dishes like curries, or use the restaurant available next door. Surrounded by nature and access to trails, waterfalls, rivers, swimming holes.

5BR House in Panama City w/ Pool & King Beds
Beautiful home in Punta Paitilla with 5 bedrooms and 4.5 bathrooms, ideal for large groups. Enjoy a private pool, spacious living areas, and a flexible layout designed for comfort and privacy. Located in one of Panama City’s most exclusive neighborhoods, within walking distance to restaurants, supermarkets, shopping centers, synagogues and just minutes from the Cinta Costera.

Villa Helena 2 Bedrooms Cerro Azul
Forget your worries in this spacious and serene space surrounded by nature in a gated community. A home away from home. 2 bedrooms for 4 adults. Your own kitchen, dining/living area, 2 washrooms and 2 bedrooms in a private villa with a pool. Cook your own food, BBQ on a gas grill or check out the restaurants in the community.

Pleasant Villa de Playa Villas Decameron Rio Hato
In this accommodation you can breathe tranquility: relax with the whole family, excellent view of the Golf course access to the private beach club we have 24-hour security, quiet place to relax and have fun with the family.

Tranquility and peace connect with Nature 🌤
Descansa en nuestra villa familiar conecta con todo los paisajes dentro de esta propiedad que es parte del Parque Nacional Chagres en nuestra villa te sentiras como en casa a pocos minutod de la ciudad.
Popular amenities for villa rentals in Panama City
Private villa rentals

Pleasant Villa de Playa Villas Decameron Rio Hato

Beautiful House in Panama w/ King Beds + Pool

La Semilla | Jungle Mansion | Panama City

Villa Helena Studio 1 Apt. Cerro Azul

Villa Helena 2 Bedrooms Cerro Azul

Casa AcoModo @Casco Viejo – Remodeled 6BR & Pool

Breathtaking Views Mansion w/King Beds

Tranquility and peace connect with Nature 🌤
Luxury villa rentals

Casa AcoModo @Casco Viejo – Remodeled 6BR & Pool

Breathtaking Views Mansion w/King Beds

Beautiful House in Panama w/ King Beds + Pool

La Semilla | Jungle Mansion | Panama City

5BR House in Panama City w/ Pool & King Beds
Villa rentals with a pool

Pleasant Villa de Playa Villas Decameron Rio Hato

Beautiful House in Panama w/ King Beds + Pool

La Semilla | Jungle Mansion | Panama City

Villa Helena Studio 1 Apt. Cerro Azul

Villa Helena 2 Bedrooms Cerro Azul

Casa AcoModo @Casco Viejo – Remodeled 6BR & Pool

Breathtaking Views Mansion w/King Beds

5BR House in Panama City w/ Pool & King Beds
Quick stats about villa rentals in Panama City

Total holiday rentals
Explore 10 holiday rentals in Panama City

Nightly prices starting at
Panama City holiday rentals start at £52 per night before taxes and fees

Verified guest reviews
Over 370 verified reviews to help you choose

Family-friendly holiday rentals
10 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 10 rentals that welcome pets

Holiday rentals with a pool
10 properties feature pools

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wifi availability
10 of Panama City holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City’s top spots include Miraflores Locks, Museo de Arte Contemporáneo and Santo Tomas (Panama Metro)
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