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House holiday rentals in Panama City

Find and book unique houses on Airbnb

Quick stats about house rentals in Panama City

  • Total holiday rentals

    Explore 480 holiday rentals in Panama City

  • Verified guest reviews

    Over 8,400 verified reviews to help you choose

  • Family-friendly holiday rentals

    200 properties offer extra space & child-friendly amenities

  • Pet-friendly holiday rentals

    Find 160 rentals that welcome pets

  • Holiday rentals with a pool

    90 properties feature pools

  • Rentals with dedicated workspaces

    240 properties have a dedicated workspace

  • Wifi availability

    440 of Panama City holiday rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City’s top spots include Miraflores Locks, Museo de Arte Contemporáneo and Santo Tomas (Panama Metro)

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness and more.

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Top guest favourite
The image showcases the exterior of a two-story house, framed by lush greenery. Sunlight filters through trees, highlighting the white façade and green shutters. A covered area is visible at the front, along with a gated fence that adds security to the property.
Home in Panama City

3BR Home in Ancon Hill - Urban Oasis

Discover our home at Ancon Hill in Panama City, steps from Supreme Court. The hill offers scenic hiking trails to the top with city views, lush greenery, and wildlife. 5 min to Albrook Mall. 10 min to Casco Viejo (UNESCO site, restaurants, museums, nightlife), Amador Causeway, Cinta Costera, Metropolitan Park, Panama Convention Center, and Albrook Airport. 20 min to Panama Canal Miraflores Locks and Veracruz beach (across Bridge of Americas, gateway to countryside). 35 min to Tocumen Airport.

4.9 out of 5 average rating, 118 reviews
Top guest favourite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

4.97 out of 5 average rating, 94 reviews
Guest favourite
Home in Panama City

Villa Flor house

Welcome to Casa Villa Flor — a comfortable and peaceful home located in the quiet San Antonio neighborhood. Conveniently located just 15 minutes from the airport, and within walking distance to MetroMall and the train station, making it easy to explore the area and travel around the city. Perfect for families or groups of up to 6 guests, the home includes: • Air conditioning • High-speed WiFi & Internet • Comfortable living spaces • Quiet residential atmosphere • No smoking

4.78 out of 5 average rating, 18 reviews
Superhost
A two-story residence features a light-colored facade with large windows allowing ample natural light. A spacious garage with a multi-car door is prominently displayed in front. The surrounding area is neatly paved, with a tranquil atmosphere suggested by the absence of heavy traffic.
Home in San Francisco

Large Private Residence in an Excellent Area

House in the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Kosher Option Available* House in one of the best areas of the country. Very quiet street, central, close to restaurants, pharmacies, mall, and more. Large, comfortable residence for groups.

4.75 out of 5 average rating, 125 reviews
Guest favourite
Home in Panama City

Private Studio 10 Min from the Airport!

Spacious, newly renovated private apartment with a separate entrance, double bed, Wi-Fi, air conditioning, TV, fully equipped kitchen, hot water and everything you need for a comfortable stay. ❤️ Transport to and from the airport for an additional cost. Private Tours: - Panama Canal + Monkey Island and Emberá Community with lunch included. - Tours from Playa to San Blas. Early check-in 7am–2pm for $15, subject to availability. Stay, relax, and let us help you discover Panama! ✨

4.94 out of 5 average rating, 444 reviews
Superhost
The exterior of a two-story residence is shown, featuring a classic design with a stone façade and wooden accents. Lush greenery surrounds the entrance, where steps lead to the upper level. Two friendly dogs can be seen in the foreground, adding a welcoming touch to the scene.
Home in Panama City

Central|Confort|surrounded by nature|Wifi|parking

Connect with the city and wonderful nature at the same time. Relaxing in a hammock on the balcony makes it unique. It will be great if you want to visit us for pleasure, work (high-speed WiFi); as a family or in groups of friends. House in the Old Canal Zone, Primer Alto; from here to explore tourist places and restaurants. (Near Bus Terminal, Metro Train, Albrook Mall, Metropolitan Park, Marcos Gelabert Airport, Old Town, Amador Coast Way, Canal de 🇵🇦)

4.84 out of 5 average rating, 118 reviews
Top guest favourite
The exterior of Villa Lola is highlighted by a welcoming sign and surrounded by lush greenery. A well-maintained outdoor space features a swimming pool beside a relaxing area with white chairs. The two-story structure showcases a charming mix of architecture with a scenic view of the surrounding nature.
Home in Panama City

Majestic Villa in the Mountains

Relax with the whole family at this peaceful place to stay. The majestic Villa Lola is a special place located in an exclusive residential area, with 24-hour security, Los Altos de Cerro Azul. A place within Chagres National Park surrounded by rivers, lakes, waterfalls, trails and endless wildlife species, where you can experience a different adventure every day. Located 55 minutes from the city and 30 minutes from Tocumen International Airport :)

4.94 out of 5 average rating, 80 reviews
Top guest favourite
A spacious living and dining area is depicted, featuring a blue sectional sofa with yellow accent pillows. A glass dining table with yellow placemats and black chairs is shown. Natural light enters through windows, revealing a glimpse of greenery outside.
Home in San Francisco

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

4.84 out of 5 average rating, 128 reviews
Superhost
A lush green lawn showcases well-maintained grass, framed by tropical plants with vibrant yellow leaves. In the background, a spacious outdoor area is visible, featuring a covered seating area. Hammocks are gently swaying, inviting relaxation amidst the natural surroundings.
Home in Panama City

Wonderful nature

Enjoy a family retreat in the heart of nature, where tranquility envelops you. This cozy accommodation, surrounded by a beautiful garden in the Metropolitan Natural Park, offers you a unique escape just 3 minutes from Albrook Mall and 5 minutes from downtown. Wake up to birdsong and a visit from the ñeques (agoutis), while relaxing in an exclusive and lively atmosphere. The perfect getaway to disconnect and enjoy nature with all the amenities!

4.82 out of 5 average rating, 57 reviews
Guest favourite
Home in San Miguelito

Casa-confort-cercaacostadeleste-familia

Discover this elegant urban oasis, a completely refurbished retreat that combines comfort and style. ​The property has a large open-plan kitchen, three bedrooms ideal for seven people, including a king-size bed and a full-size bed, as well as two parking spaces. ​Enjoy relaxing afternoons on the outdoor terrace and take advantage of its unbeatable location just one block from Plaza de Santa María and two minutes from Costa del Este.

5.0 out of 5 average rating, 5 reviews
Superhost
A serene courtyard features a small pool surrounded by terracotta tiles and smooth wooden planks. Lush green plants are displayed throughout the space, enhancing the tranquil environment. The walls are adorned with original stonework, blending history with nature.
Home in San Felipe

Cozy house in Casco Viejo with private pool

Historic accommodation in the heart of the Old Town Enjoy a unique experience in this accommodation located in the centre of the Old Town. The property has been carefully restored several times by renowned Panamanian architects, including Sebastián Paniza. Its most outstanding features include a historic well within the property, as well as original walls and floors that preserve the spirit and authenticity of the place.

4.79 out of 5 average rating, 131 reviews
Guest favourite
Home in Panama City

House for groups · 6 bedrooms/6 bathrooms near the Canal

Casa Randa is a fully equipped house ideal for families, friends and groups who value space and privacy. It has six rooms, each with a private bathroom, TV, minibar, air conditioning and ceiling fan. Enjoy a fully equipped kitchen, spacious social areas, Wi-Fi, a free washing machine and dryer, a BBQ, and private parking. Located in the quiet area of Diablo Heights, with easy access to the Panama Canal, Albrook and Gamboa.

4.89 out of 5 average rating, 18 reviews

Popular amenities for house rentals in Panama City

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