
Holiday rentals in Panama City
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Top-rated holiday rentals in Panama City
Guests agree: these stays are highly rated for location, cleanliness and more.

The Penthouse Annex
Inspired by Panama's rich history with France and located in one of the oldest watch towers in Panama, this chic apartment combines original features of this historically important building with the elegance and style of Europe. Perfectly situated to indulge in the restaurants, cafes, museums and boutique stores of Casco Viejo, and equipped with everything you expect from a home-from-home base, the annex is the perfect combination of comfort and style for couples and small groups of friends.

Tropicool Loft w/rooftop steps from Casco
This historic 1941 loft is located at the entrance of Casco Viejo where you’re steps from the fish market and all the cool cafés, rooftops, and trendy restaurants that make up the neighborhood. Fully equipped kitchen, washer/dryer combo, 1.5 bath, bedroom on 2nd floor, 2 balconies + communal rooftop, projector w/Netflix, fast internet, and great AC. You’re also directly in front of the Cinta Costera park for running, biking, tennis courts. Near local airport for flights to Bocas!

Central, comfortable studio with bay view
Enjoy a stay in the Center of Panama City! Small, equipped and comfortable studio on Av. Centro de España with 42nd Street in Bella Vista, ideal for one or two travelers. Steps from the Santo Tomás Metro station. A 5-minute walk from the Cinta Costera going down, Parque Urracá, Supermarket Rey and Riba Smith, Zona Bancaria (Calle 50), Calle Uruguay (restaurant area), 15 minutes by car from the Old Town and more. Enjoy the different amenities we offer you!

Oceanview Paradise in Panama City!
Welcome to this stunning 1 bedroom, 2 bath condo in the heart of Avenida Balboa, Panama City! This property offers a fantastic opportunity for those seeking a comfortable and modern living space with a ton of amenities, while being only a short stroll away from beautiful Casco Veijo (Old Town). And an added bonus: the Sands building has a stop for the Hop on/Hop off bus for the attraction on the rooftop called "The Poin" - the zipline and rock climbing wall!

Cosy apartment facing the sea.
This place is unique, it has its own style. Its location is strategic, it will be very easy to get there. It is located next to the Cinta Costera, near the metro station, Casco Antiguo, and all the tourist centers that Panama offers you. Come and enjoy this beautiful experience in one of the best buildings in Panama, which offers tranquility, entertainment, gastronomy, cocktails, history of Panama, breathtaking views, all within the same building. Visit us!

Escape to the Heart of Casco with a Private Balcony
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Modern and Central · Nice Condo in the Heart of Pty
¡Modern 50 m2 apartment located on Calle 50, in the heart of Panama City!. With access to the best in art, culture, business, finance, sports, shopping, food, and nightlife. * The space has a room with a queen size bed, full bathroom, smart TV and desk with monitor (HDMI cable) for those traveling without disconnecting from work. * The living room has a comfortable sofa bed, full bathroom, dining room and kitchen equipped for kitchen lovers!.

Beautiful Apartment 3 guests
Moderno, elegante y cómodo departamento, cerca de todo! Restaurantes, farmacias, supermercados, canchas de padle, a pocos minutos del centro comercial Multiplaza. Totalmente amoblado, 1 recamara, 1 baño completo, walking closet, cocina, sala, área de desayunador, lavadora-secadora y balcón. Para su disfrute, piscina de agua salada en el último piso, gimnasio, espacio de co-working, incluye un espacio de estacionamiento con valet parking.

Luxury apartment in downtown Panama, banking area
We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

Modern apartment in the Historic Center
I invite you to this apartment in La Manzana, Santa Ana. This place has a strategic location - it will be very easy to plan your visit! It is only 2 minutes walking from Casco Viejo. Our studio offers an ideal location to enjoy the Casco and the entire city. We have Wifi, hotel bed, fully equipped kitchen, working space, TV and hot shower. In addition, the building has 24 hour security so you have nothing to worry about!!

King Bed, Creative Design Steps from Casco Viejo
Casco 114 is a stay created by travelers, for travelers. Located in the heart of Santa Ana, the creative district of Panama’s Casco viejo, it offers a king bed, full-size trundle, sofa bed, private terrace, washer/dryer, and unique decor. At PH Casco View: enjoy a saltwater pool, coworking space, stunning views of both the Old Town and the modern city, paid parking, and all the comforts for an unforgettable stay.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.
Popular amenities for Panama City holiday rentals
Other great holiday rentals in Panama City

New Modern Condo 1BR Best Location! Rooftop Pool

A Modern & Cozy Apartment In Prime Location

Spacious oceanfront apartment

Luxurious Apartment Oceanfront View

VIP Suite/Sea View + Pool & Sky Lounge + Gym

w* | Impeccable 1BR in Casco Viejo

Casa Malva

k*| Delightful 1 BR w/King Bed in Calle 50
Quick stats about holiday rentals in Panama City
Total holiday rentals
Explore 4,740 holiday rentals in Panama City
Nightly prices starting at
Panama City holiday rentals start at £7 per night before taxes and fees
Verified guest reviews
Over 114,280 verified reviews to help you choose
Family-friendly holiday rentals
1,480 properties offer extra space & child-friendly amenities
Pet-friendly holiday rentals
Find 1,680 rentals that welcome pets
Holiday rentals with a pool
2,570 properties feature pools
Rentals with dedicated workspaces
2,880 properties have a dedicated workspace
Wifi availability
4,490 of Panama City holiday rentals include wifi access
Popular amenities for guests
Guests love Gym, BBQ grill and Laptop-friendly workspace across Panama City rentals
4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests
Nearby attractions
Panama City’s top spots include Miraflores Locks, Museo de Arte Contemporáneo and Santo Tomas (Panama Metro)
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