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Mansion holiday rentals in Panama

Find and book unique mansions on Airbnb

Top-rated mansion rentals in Panama

Guests agree: these mansions are highly rated for location, cleanliness and more.

Superhost
Earthen home in El Cope, Penonome
Beautiful Eco House in Panama
We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.
17–24 JunIndividual Host,
£174 per night
4.91 out of 5 average rating, 137 reviews
Guest favourite
Cottage in Punta Chame
Beach House with Pool/Gazebo in Punta Chame!
"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"
27 Apr – 4 MayIndividual Host,
£174 per night
4.99 out of 5 average rating, 100 reviews
Guest favourite
Apartment in Panamá
Los Diamantes Maximo. Prepare to be stunned.
A penthouse apartment, "Maximo" is in an ancestral home of a famous Panamanian family. 2 levels, 4 bedrooms, 3 of which have en-suite bathrooms, 5 meter ceilings, a huge rooftop terrace overlooking the ocean, and also with an enormous balcony overlooking Plaza Herrera, the heart of Casco Viejo. Need more space in the same building? We also have these properties. Add the path to airbnb.com to view: /h/terraza2 /h/herrera3 /h/cuteroomdiamantes
24–31 JulProfessional Host,
£209 per night
4.96 out of 5 average rating, 153 reviews

Popular amenities for Panama mansion rentals

Luxury mansion rentals

Guest favourite
Villa in Panamá
Beautiful House in Panama w/ King Beds + Pool
10–17 OctProfessional Host,
£506 per night
4.98 out of 5 average rating, 43 reviews
Superhost
Villa in Saboga
Casa Laguna - luxury beach front house with pool
10–17 JulIndividual Host,
£551 per night
4.83 out of 5 average rating, 6 reviews
Guest favourite
Villa in Panamá
Breathtaking Views Mansion w/King Beds
7–14 JulIndividual Host,
£458 per night
5.0 out of 5 average rating, 24 reviews
Guest favourite
Villa in Bocas del Toro
Casa del Mar - eco aqua villa
10–17 JanIndividual Host,
£456 per night
5.0 out of 5 average rating, 52 reviews
Guest favourite
Home in Río Hato
Spectacular beachfront house in Buenaventura!
6–13 MayIndividual Host,
£548 per night
4.94 out of 5 average rating, 72 reviews
Guest favourite
Villa in Buenaventura, El Chirú
Lake House | Pool | King Beds | Next to Beach Club
13–20 AugProfessional Host,
£697 per night
4.88 out of 5 average rating, 33 reviews
Superhost
Flat in Panamá
Exclusive villa with splash pool by the sea
4–11 FebProfessional Host,
£655 per night
4.57 out of 5 average rating, 84 reviews
Superhost
Villa in Las Escobas del Venado
Breathtaking Ocean Villa. Casa de Vida
23–30 JulIndividual Host,
£478 per night
4.95 out of 5 average rating, 20 reviews
Guest favourite
Villa in Bejuco
Beach house in Punta Chame, Villa frente al mar
2–9 MayIndividual Host,
£576 per night
4.96 out of 5 average rating, 78 reviews
Superhost
Villa in Contadora Island
Beachfront Villa With Direct Beach Access & Pool
14–21 AugIndividual Host,
£819 per night
4.66 out of 5 average rating, 35 reviews
Guest favourite
Flat in Maria Chiquita
Penthouse in Playa Escondida 4 bedrooms
4–11 NovIndividual Host,
£690 per night
4.95 out of 5 average rating, 19 reviews
Superhost
Villa in San Carlos
Villa Serenidad by AcoModo
28 Jun – 5 JulProfessional Host,
£446 per night
4.83 out of 5 average rating, 24 reviews

Pet-friendly mansion rentals

Guest favourite
Flat in Panamá
Apartment in Buenaventura with exclusive own pool
8–15 JulIndividual Host,
£258 per night
4.94 out of 5 average rating, 116 reviews
Guest favourite
Villa in Farallon
4 Bedroom Costa Blanca Golf & Beach Villa
18–25 FebIndividual Host,
£204 per night
4.91 out of 5 average rating, 187 reviews
Guest favourite
Home in Panama
Villa Isabella in Coronado Beach Panama
26 Jan – 2 FebIndividual Host,
£295 per night
4.96 out of 5 average rating, 136 reviews
Guest favourite
Apartment in El Chirú
Buenaventura Paseo de las Casas Apartment
19–26 MayIndividual Host,
£228 per night
4.85 out of 5 average rating, 152 reviews
Superhost
Home in Pedasí
Ocean View From The Jungle!
2–9 JulIndividual Host,
£230 per night
5.0 out of 5 average rating, 4 reviews
Guest favourite
Home in San Carlos
Beach House-Ocean View Rooftop Jacuzzi & Pool
4–11 JunIndividual Host,
£216 per night
4.93 out of 5 average rating, 82 reviews
Superhost
Home in Playa Malibú
oceanfront home villa in malibu
12–19 JulIndividual Host,
£298 per night
4.63 out of 5 average rating, 103 reviews
Guest favourite
Villa in Punta Chame
Amazing Beachfront Villa - Palm House
11–18 DecIndividual Host,
£378 per night
4.9 out of 5 average rating, 10 reviews
Guest favourite
Villa in Portobelo
Entire Villa with pool in front of beach!
23–30 AugIndividual Host,
£199 per night
5.0 out of 5 average rating, 35 reviews
Guest favourite
Cottage in Altos del Maria
Cabin with Spectacular Mountain View
30 Jul – 6 AugIndividual Host,
£261 per night
4.93 out of 5 average rating, 91 reviews
Superhost
Home in Gamboa
BirdHouse@ Gamboa Panamá Canal
12–19 FebIndividual Host,
£289 per night
4.88 out of 5 average rating, 80 reviews
Guest favourite
Apartment in San Carlos District
Punta Caelo Beach Front View
3–10 OctIndividual Host,
£263 per night
5.0 out of 5 average rating, 32 reviews

Mansion rentals with a pool

Guest favourite
Villa in Río Hato
Luxury 4BR Villa + Guesthouse & Pool @Buenaventura
17–24 MayProfessional Host,
£361 per night
5.0 out of 5 average rating, 36 reviews
Guest favourite
Apartment in Buenaventura, El Chirú
Stylish & Quiet ~ Breathtaking Laguna Views ~Pool
9–16 AprIndividual Host,
£215 per night
4.99 out of 5 average rating, 92 reviews
Guest favourite
Flat in Maria Chiquita
Spacious 4Br Beachside Getaway at Playa Escondida
19–26 MayIndividual Host,
£376 per night
5.0 out of 5 average rating, 51 reviews
Guest favourite
Flat in María Chiquita
Playa Escondida Resort & Marina
19–26 AugIndividual Host,
£331 per night
4.93 out of 5 average rating, 60 reviews
Guest favourite
Flat in Panama City
24o Penthouse Unique Design 2 Balconies Oceanview
12–19 JanProfessional Host,
£407 per night
5.0 out of 5 average rating, 19 reviews
Guest favourite
Villa in Costa Esmeralda
Spectacular 600-meter oceanfront beach house
23–30 JanIndividual Host,
£296 per night
5.0 out of 5 average rating, 12 reviews
Guest favourite
Home in Cacique
El Paraiso
23–30 JunIndividual Host,
£229 per night
5.0 out of 5 average rating, 16 reviews
Guest favourite
Chalet in Panamá
luxurious cottage, pleasant climate,with fireplace, jacuzzi, pool table, parade area, campfire and more...
9–16 NovIndividual Host,
£169 per night
4.79 out of 5 average rating, 61 reviews
Superhost
Home in Bastimentos
Spacious, Over the Water Home with Plunge Pool
2–9 SeptIndividual Host,
£312 per night
4.8 out of 5 average rating, 92 reviews
Superhost
Flat in Maria Chiquita
A Hidden Gem in the Caribbean Paradise
14–21 AprIndividual Host,
£330 per night
4.78 out of 5 average rating, 90 reviews
Superhost
Home in Panamá
Private Pool House with BBQ and more
8–15 OctIndividual Host,
£387 per night
4.86 out of 5 average rating, 29 reviews
Guest favourite
Apartment in El Chirú
Buenaventura beach condo with private pool
5–12 MarIndividual Host,
£259 per night
4.88 out of 5 average rating, 78 reviews

Destinations to explore

  1. Airbnb
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  3. Mansion rentals